Search Results - "Nylander, Vibe"

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci by Thurner, Matthias, van de Bunt, Martijn, Torres, Jason M, Mahajan, Anubha, Nylander, Vibe, Bennett, Amanda J, Gaulton, Kyle J, Barrett, Amy, Burrows, Carla, Bell, Christopher G, Lowe, Robert, Beck, Stephan, Rakyan, Vardhman K, Gloyn, Anna L, McCarthy, Mark I

“…Human genetic studies have emphasised the dominant contribution of pancreatic islet dysfunction to development of Type 2 Diabetes (T2D). However, limited…”
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Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D by Viñuela, Ana, Varshney, Arushi, van de Bunt, Martijn, Prasad, Rashmi B., Asplund, Olof, Bennett, Amanda, Boehnke, Michael, Brown, Andrew A., Erdos, Michael R., Fadista, João, Hansson, Ola, Hatem, Gad, Howald, Cédric, Iyengar, Apoorva K., Johnson, Paul, Krus, Ulrika, MacDonald, Patrick E., Mahajan, Anubha, Manning Fox, Jocelyn E., Narisu, Narisu, Nylander, Vibe, Orchard, Peter, Oskolkov, Nikolay, Panousis, Nikolaos I., Payne, Anthony, Stitzel, Michael L., Vadlamudi, Swarooparani, Welch, Ryan, Collins, Francis S., Mohlke, Karen L., Gloyn, Anna L., Scott, Laura J., Dermitzakis, Emmanouil T., Groop, Leif, Parker, Stephen C. J., McCarthy, Mark I.

“…Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation…”
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DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human by Simar, David, Versteyhe, Soetkin, Donkin, Ida, Liu, Jia, Hesson, Luke, Nylander, Vibe, Fossum, Anna, Barrès, Romain

“…Abstract Objective Obesity is associated with low-grade inflammation and the infiltration of immune cells in insulin-sensitive tissues, leading to metabolic…”
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Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals by Wesolowska-Andersen, Agata, Zhuo Yu, Grace, Nylander, Vibe, Abaitua, Fernando, Thurner, Matthias, Torres, Jason M, Mahajan, Anubha, Gloyn, Anna L, McCarthy, Mark I

“…Genome-wide association analyses have uncovered multiple genomic regions associated with T2D, but identification of the causal variants at these remains a…”
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Ionizing Radiation Potentiates High-Fat Diet-Induced Insulin Resistance and Reprograms Skeletal Muscle and Adipose Progenitor Cells by Nylander, Vibe, Ingerslev, Lars R, Andersen, Emil, Fabre, Odile, Garde, Christian, Rasmussen, Morten, Citirikkaya, Kiymet, Bæk, Josephine, Christensen, Gitte L, Aznar, Marianne, Specht, Lena, Simar, David, Barrès, Romain

“…Exposure to ionizing radiation increases the risk of chronic metabolic disorders such as insulin resistance and type 2 diabetes later in life. We hypothesized…”
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Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation by Wesolowska-Andersen, Agata, Jensen, Rikke Rejnholdt, Alcántara, Marta Pérez, Beer, Nicola L., Duff, Claire, Nylander, Vibe, Gosden, Matthew, Witty, Lorna, Bowden, Rory, McCarthy, Mark I., Hansson, Mattias, Gloyn, Anna L., Honore, Christian

“…Several distinct differentiation protocols for deriving pancreatic progenitors (PPs) from human pluripotent stem cells have been described, but it remains to…”
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T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors by Daniel, Sara, Nylander, Vibe, Ingerslev, Lars R, Zhong, Ling, Fabre, Odile, Clifford, Briana, Johnston, Karen, Cohn, Richard J, Barres, Romain, Simar, David

“…Cancer treatments have substantially improved childhood cancer survival but are accompanied by long-term complications, notably chronic inflammatory diseases…”
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Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells by Torres, Jason M, Sun, Han, Nylander, Vibe, Downes, Damien J, van de Bunt, Martijn, McCarthy, Mark I, Hughes, Jim R, Gloyn, Anna L

“…Resolving causal genes for type 2 diabetes at loci implicated by genome-wide association studies (GWAS) requires integrating functional genomic data from…”
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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps by Mahajan, Anubha, Taliun, Daniel, Thurner, Matthias, Robertson, Neil R., Torres, Jason M., Rayner, N. William, Payne, Anthony J., Steinthorsdottir, Valgerdur, Scott, Robert A., Grarup, Niels, Schmidt, Ellen M., Wuttke, Matthias, Sarnowski, Chloé, Mägi, Reedik, Nano, Jana, Gieger, Christian, Trompet, Stella, Lecoeur, Cécile, Preuss, Michael H., Prins, Bram Peter, Guo, Xiuqing, Bielak, Lawrence F., Below, Jennifer E., Bowden, Donald W., Kim, Young Jin, Petty, Lauren E., Sim, Xueling, Bennett, Amanda J., Bork-Jensen, Jette, Brummett, Chad M., Canouil, Mickaël, Ec kardt, Kai-Uwe, Fischer, Krista, Kardia, Sharon L. R., Kronenberg, Florian, Läll, Kristi, Luan, Jian’an, Ntalla, Ioanna, Nylander, Vibe, Schönherr, Sebastian, Schurmann, Claudia, Yengo, Loïc, Bottinger, Erwin P., Brandslund, Ivan, Christensen, Cramer, Dedoussis, George, Florez, Jose C., Ford, Ian, Franco, Oscar H., Frayling, Timothy M., Giedraitis, Vilmantas, Hackinger, Sophie, Hattersley, Andrew T., Herder, Christian, Ikram, M. Arfan, Jørgensen, Marit E., Jørgensen, Torben, Kriebel, Jennifer, Kuusisto, Johanna, Ligthart, Symen, Linneberg, Allan, Lyssenko, Valeriya, Mamakou, Vasiliki, Meitinger, Thomas, Morris, Andrew D., Nadkarni, Girish, Pankow, James S., Peters, Annette, Sattar, Naveed, Stančáková, Alena, Strauch, Konstantin, Taylor, Kent D., Thorand, Barbara, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tuomilehto, Jaakko, Witte, Daniel R., Dupuis, Josée, Peyser, Patricia A., Zeggini, Eleftheria, Froguel, Philippe, Ingelsson, Erik, Lind, Lars, Laakso, Markku, Collins, Francis S., Jukema, J. Wouter, Grallert, Harald, Metspalu, Andres, Köttgen, Anna, Abecasis, Goncalo R., Meigs, James B., Rotter, Jerome I., Marchini, Jonathan, Hansen, Torben, Langenberg, Claudia, Wareham, Nicholas J., Stefansson, Kari, Morris, Andrew P., Boehnke, Michael, McCarthy, Mark I.

“…We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density…”
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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma by Chung, Katherine Minjee, Singh, Jaffarguriqbal, Lawres, Lauren, Dorans, Kimberly Judith, Garcia, Cathy, Burkhardt, Daniel B., Robbins, Rebecca, Bhutkar, Arjun, Cardone, Rebecca, Zhao, Xiaojian, Babic, Ana, Vayrynen, Sara A., Dias Costa, Andressa, Nowak, Jonathan A., Chang, Daniel T., Dunne, Richard F., Hezel, Aram F., Koong, Albert C., Wilhelm, Joshua J., Bellin, Melena D., Nylander, Vibe, Gloyn, Anna L., McCarthy, Mark I., Kibbey, Richard G., Krishnaswamy, Smita, Wolpin, Brian M., Jacks, Tyler, Fuchs, Charles S., Muzumdar, Mandar Deepak

“…Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression is not well…”
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A Multi-omic Integrative Scheme Characterizes Tissues of Action at Loci Associated with Type 2 Diabetes by Torres, Jason M., Abdalla, Moustafa, Payne, Anthony, Fernandez-Tajes, Juan, Thurner, Matthias, Nylander, Vibe, Gloyn, Anna L., Mahajan, Anubha, McCarthy, Mark I.

“…Resolving the molecular processes that mediate genetic risk remains a challenge because most disease-associated variants are non-coding and functional…”
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TIGER: The gene expression regulatory variation landscape of human pancreatic islets by Alonso, Lorena, Piron, Anthony, Morán, Ignasi, Guindo-Martínez, Marta, Bonàs-Guarch, Sílvia, Atla, Goutham, Miguel-Escalada, Irene, Royo, Romina, Puiggròs, Montserrat, Garcia-Hurtado, Xavier, Suleiman, Mara, Marselli, Lorella, Esguerra, Jonathan L.S., Turatsinze, Jean-Valéry, Torres, Jason M., Nylander, Vibe, Chen, Ji, Eliasson, Lena, Defrance, Matthieu, Amela, Ramon, Mulder, Hindrik, Gloyn, Anna L., Groop, Leif, Marchetti, Piero, Eizirik, Decio L., Ferrer, Jorge, Mercader, Josep M., Cnop, Miriam, Torrents, David

“…Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular…”
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309-OR: Deep Learning Model of Pancreatic Islet Epigenome Refines Association Signals at Type 2 Diabetes Susceptibility Loci by WESOLOWSKA-ANDERSEN, AGATA, THURNER, MATTHIAS, MAHAJAN, ANUBHA, ABAITUA, FERNANDO, TORRES, JASON, NYLANDER, VIBE, GLOYN, ANNA L., MCCARTHY, MARK

“…Translation of genome-wide association study findings is hampered by challenges in pinpointing the causal variant and interpretation of the biological…”
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Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells by Hastoy, Benoît, Godazgar, Mahdieh, Clark, Anne, Nylander, Vibe, Spiliotis, Ioannis, van de Bunt, Martijn, Chibalina, Margarita V., Barrett, Amy, Burrows, Carla, Tarasov, Andrei I., Scharfmann, Raphael, Gloyn, Anna L., Rorsman, Patrik

“…Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used…”
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Abstract A35: Microenvironmental adaptations drive obesity-associated pancreatic cancer by Chung, Katherine Minjee, Singh, Jaffarguribal, Lawres, Lauren, Dorans, Kimberly Judith, Robbins, Rebecca, Bhutkar, Arjun, Babic, Ana, Vayrynen, Sara A., Costa, Andressa D., Nowak, Jonathan A., Chang, Daniel T., Dunne, Richard F., Hezel, Aram F., Koong, Albert C., Wilhelm, Joshua J., Bellin, Melena D., Nylander, Vibe, Gloyn, Anna L., McCarthy, Mark I., Wolpin, Brian M., Jacks, Tyler, Fuchs, Charles S., Muzumdar, Mandar Deepak

“…Abstract Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how obesity contributes to pancreatic cancer development is…”
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