Search Results - "Nykänen, A.I"

Normal Impact of Restrictive and Obstructive Subtypes of Chronic Lung Allograft Dysfunction on Graft Survival - Single Center 13 Year Experience by Nykänen, A.I, Halme, M, Stark, C, Hämmäinen, P, Lemström, K.B, Raivio, P

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Systemic Inhibition of Angiopoietin-2 Prevents Endothelial Activation, and Acute Rejection in Rat Cardiac Allografts by Syrjälä, S.O, Dashkevich, A, Nykänen, A.I, Leow, C.C, Alitalo, K, Lemström, K.B

“…Purpose Angiopoietin-2 (Ang2) is vascular growth factor promoting vascular instability and inflammation. In our previous study, heart-targeted Ang2-inhibition…”
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Differential Effects of Pharmacological HIF Preconditioning of Donors Versus Recipients in Rat Cardiac Allografts by Keränen, M. A. I., Tuuminen, R., Syrjälä, S., Krebs, R., Walkinshaw, G., Flippin, L. A., Arend, M., Koskinen, P. K., Nykänen, A. I., Lemström, K. B.

“…Ischemia‐reperfusion injury (IRI) induces hypoxia‐inducible factor‐1 (HIF‐1) in the myocardium, but the consequences remain elusive. We investigated HIF‐1…”
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Intracoronary Treatment with VEGF-C/D Inhibitor Enhances Cardiac Allograft Survival and Prevents Chronic Rejection by Regulating Lymphatic Endothelial Cell Activation by Dashkevich, A, Syrjälä, S.O, Keränen, M.A, Tuuminen, R, Krebs, R, Nykänen, A.I, Alitalo, K, Lemström, K.B

“…Purpose VEGF-C/D/VEGFR-3 signaling may regulate lymphatic vessel activation and the initiation of alloimmunity after transplantation. We investigated the…”
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92 Donor Treatment with Simvastatin and Methylprednisolone Targets Microvascular-Myelomonocyte Interactions and Improves Cardiac Allograft Survival by Tuuminen, R, Syrjälä, S, Krebs, R, Arnaudova, R, Rouvinen, E, Nykänen, A.I, Lemström, K.B

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331 COMP-Ang1 Reduces Ischemia-Reperfusion Injury-Induced Microvascular Dysfunction and Chronic Rejection in Rat Cardiac Allografts by Syrjala, S.O, Tuuminen, R, Raissadati, A, Keränen, M.A, Krebs, R, Nykänen, A.I, Koh, G.-Y, Alitalo, K, Lemström, K.B

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Ex Vivo Intracoronary Gene Transfer of Adeno Associated Virus Serotype 2 Is Superior to Serotypes 8 and 9 in Transfecting Heart Transplants in the Rat by Raissadati, A, Jokinen, J.J, Syrjälä, S.O, Tuuminen, R, Krebs, R, Arnaudova, R, Keränen, M.A, Anisimov, A, Soronen, J, Pajusola, K, Alitalo, K, Nykänen, A.I, Lemström, K

“…Purpose Comparison of transgene expression, localization, kinetics, and efficiency of adeno-associated virus 2 (AAV2) and novel AAV8 and AAV9 in syngenic heart…”
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378 Constantly Stable Hypoxia Inducible Factor-1 in Myeloid Cells Prevents Acute Rejection In Mouse Cardiac Allografts by Keränen, M.A.I, Syrjala, S, Krebs, R, Tuuminen, R, Johnson, R.S, Nykänen, A.I, Lemström, K.B

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341 VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease by Krebs, R, Tikkanen, J.M, Ropponen, J.O, Jeltsch, M, Jokinen, J.J, Ylä-Herttuala, S, Koskinen, P.K, Nykänen, A.I, Lemström, K.B

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232: Simvastatin Treatment Inhibits the Development of Obliterative Airway Disease in Rat Tracheal Allografts by Tikkanen, J.M, Nykänen, A.I, Hollmén, M, Krebs, R, Lemström, K.B

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360: Constantly Stable HIF-1α in Myeloid Cells Prevents Acute Rejection in Rat Cardiac Allografts by Keränen, M.A.I, Tuuminen, R, Nykänen, A.I, Tavast, E, Koskinen, P.K, Johnson, R.S, Lemström, K.B

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29: Role of Vascular Endothelial Growth Factor-C in Experimental Obliterative Airway Disease by Krebs, R, Tikkanen, J.M, Nykänen, A.I, Alitalo, K, Ylä-Herttuala, S, Koskinen, P.K, Lemström, K.B

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426: Vascular endothelial growth factor-C enhances experimental obliterative bronchiolitis by inducing lymphangiogenesis by Krebs, R, Tikkanen, J.M, Nykänen, A.I, Ylä-Herttuala, S, Koskinen, P.K, Lemström, K.B

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373: Alloimmune response induces HIF-1 activation in vascular and inflammatory cells of transplanted hearts – possible link to cardiac allograft vasculopathy by Keränen, M.A.I, Nykänen, A.I, Krebs, R, Sandelin, H, Tuuminen, R, Koskinen, P.K, Lemström, K.B

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Donor Simvastatin Treatment is More Effective in Donors with Low Plasma Levels of Arginine by Dhaygude, K.U., Nykänen, A.I., Krebs, R., Lemström, K.

“…Brain death may lead to a severe impairment of endothelial function and affect graft function. Recent study shows that simvastatin treatment to the organ donor…”
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417: Constitutively Expressed Hypoxia-Inducible Factor-1α Prevents the Development of Cardiac Allograft Vasculopathy in the Rat by Keränen, M.A.I, Nykänen, A.I, Krebs, R, Sandelin, H, Tuuminen, R, Alitalo, K, Pajusola, K, Ylä-Herttuala, S, Koskinen, P.K, Lemström, K.B

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Effect of Donor Simvastatin Treatment on Cardiac Allograft Ischemia-Reperfusion Injury - 30-Day Analysis of a Randomized Prospective Single-Center Clinical Trial by Nykanen, A.I, Holmström, E, Syrjälä, S, Jokinen, J, Krebs, R, Lemström, K.B

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Donor Metabolic Risk Score Predicts Graft-Related  Outcome After Heart Transplantation by Dhaygude, K.U., Suominen, T., Krebs, R., Joo, S., Holmström, E.J., Syrjälä, S.O., Nykänen, A.I., Lemström, K.B.

“…Brain death  may  trigger  profound metabolic and molecular changes that significantly affect the function of the heart transplant. We  investigated the effect…”
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Plasma Proteome of Brain-Dead Organ Donors as a Predictor of Graft-Related Outcomes After Heart Transplantation by Lukac, J., Dhaygude, K., Saraswat, M., Joenväärä, S., Syrjälä, S.O., Holmström, E.J., Krebs, R., Renkonen, R., Nykänen, A.I., Lemström, K.B.

“…Most solid organ transplantations are performed using organs from brain-dead donors. The inflammatory, cardiovascular, hormonal, and metabolic changes related…”
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Ischemia–Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts by Dashkevich, A., Raissadati, A., Syrjälä, S. O., Zarkada, G., Keränen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppänen, V.‐M., Alitalo, K., Nykänen, A. I., Lemström, K. B.

“…Organ damage and innate immunity during heart transplantation may evoke adaptive immunity with serious consequences. Because lymphatic vessels bridge innate…”
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