Search Results - "Nyholt, Dale R."

SECA: SNP effect concordance analysis using genome-wide association summary results by Nyholt, Dale R

“…The genomics era provides opportunities to assess the genetic overlap across phenotypes at the measured genotype level; however, current approaches require…”
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Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine by Tanha, Hamzeh M., Nyholt, Dale R.

“…Migraine is a common complex disorder with a significant polygenic SNP heritability ( h S N P 2 ). Here we utilise genome-wide association study (GWAS) summary…”
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Co-occurrence and symptomatology of fatigue and depression by Corfield, Elizabeth C, Martin, Nicholas G, Nyholt, Dale R

“…Abstract Objective Fatigue and depression are highly comorbid phenotypes with partially overlapping symptoms. The main aims of the present study are to: i)…”
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Common SNPs explain a large proportion of the heritability for human height by Heath, Andrew C, Benyamin, Beben, Nyholt, Dale R, Goddard, Michael E, Gordon, Scott, Martin, Nicholas G, Henders, Anjali K, Madden, Pamela A, Visscher, Peter M, McEvoy, Brian P, Yang, Jian, Montgomery, Grant W

“…Peter Visscher and colleagues report an analysis of the heritability explained by common variants identified through genome-wide association studies. They find…”
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Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets by Rahmioglu, Nilufer, Nyholt, Dale R, Morris, Andrew P, Missmer, Stacey A, Montgomery, Grant W, Zondervan, Krina T

“…Endometriosis is a heritable common gynaecological condition influenced by multiple genetic and environmental factors. Genome-wide association studies (GWASs)…”
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Genome-wide imputed differential expression enrichment analysis identifies trait-relevant tissues by Ghaffar, Ammarah, Nyholt, Dale R

“…The identification of pathogenically-relevant genes and tissues for complex traits can be a difficult task. We developed an approach named genome-wide imputed…”
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Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect by Broer, Linda, Codd, Veryan, Nyholt, Dale R, Deelen, Joris, Mangino, Massimo, Willemsen, Gonneke, Albrecht, Eva, Amin, Najaf, Beekman, Marian, de Geus, Eco J C, Henders, Anjali, Nelson, Christopher P, Steves, Claire J, Wright, Margie J, de Craen, Anton J M, Isaacs, Aaron, Matthews, Mary, Moayyeri, Alireza, Montgomery, Grant W, Oostra, Ben A, Vink, Jacqueline M, Spector, Tim D, Slagboom, P Eline, Martin, Nicholas G, Samani, Nilesh J, van Duijn, Cornelia M, Boomsma, Dorret I

“…Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies…”
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Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine by Gerring, Zachary F, McRae, Allan F, Montgomery, Grant W, Nyholt, Dale R

“…Migraine is a common heritable neurovascular disorder typically characterised by episodic attacks of severe pulsating headache and nausea, often accompanied by…”
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Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1 by Burdon, Kathryn P, Macgregor, Stuart, Hewitt, Alex W, Sharma, Shiwani, Chidlow, Glyn, Mills, Richard A, Danoy, Patrick, Casson, Robert, Viswanathan, Ananth C, Liu, Jimmy Z, Landers, John, Henders, Anjali K, Wood, John, Souzeau, Emmanuelle, Crawford, April, Leo, Paul, Wang, Jie Jin, Rochtchina, Elena, Nyholt, Dale R, Martin, Nicholas G, Montgomery, Grant W, Mitchell, Paul, Brown, Matthew A, Mackey, David A, Craig, Jamie E

“…Jamie Craig and colleagues report a genome-wide association study for advanced open angle glaucoma (OAG). They identify variants near TMCO1 and in CDKN2B-AS1…”
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Genome-wide association meta-analysis identifies new endometriosis risk loci by Nyholt, Dale R, Low, Siew-Kee, Anderson, Carl A, Painter, Jodie N, Uno, Satoko, Morris, Andrew P, MacGregor, Stuart, Gordon, Scott D, Henders, Anjali K, Martin, Nicholas G, Attia, John, Holliday, Elizabeth G, McEvoy, Mark, Scott, Rodney J, Kennedy, Stephen H, Treloar, Susan A, Missmer, Stacey A, Adachi, Sosuke, Tanaka, Kenichi, Nakamura, Yusuke, Zondervan, Krina T, Zembutsu, Hitoshi, Montgomery, Grant W

“…Dale Nyholt and colleagues report a genome-wide association meta-analysis of endometriosis in individuals of Japanese and European ancestry. They report a new…”
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Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity by Adewuyi, Emmanuel O, Sapkota, Yadav, International Endogene Consortium Iec, andMe Research Team, International Headache Genetics Consortium Ihgc, Auta, Asa, Yoshihara, Kosuke, Nyegaard, Mette, Griffiths, Lyn R, Montgomery, Grant W, Chasman, Daniel I, Nyholt, Dale R

“…Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology…”
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Novel hypotheses emerging from GWAS in migraine? by van den Maagdenberg, Arn M. J. M., Nyholt, Dale R., Anttila, Verneri

“…Recent technical advances in genetics made large-scale genome-wide association studies (GWAS) in migraine feasible and have identified over 40 common DNA…”
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A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders by Adewuyi, Emmanuel O., O’Brien, Eleanor K., Nyholt, Dale R., Porter, Tenielle, Laws, Simon M.

“…Consistent with the concept of the gut-brain phenomenon, observational studies suggest a relationship between Alzheimer’s disease (AD) and gastrointestinal…”
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Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology by Heilmann, Stefanie, Kiefer, Amy K., Fricker, Nadine, Drichel, Dmitriy, Hillmer, Axel M., Herold, Christine, Tung, Joyce Y., Eriksson, Nicholas, Redler, Silke, Betz, Regina C., Li, Rui, Kárason, Ari, Nyholt, Dale R., Song, Kijoung, Vermeulen, Sita H., Kanoni, Stavroula, Dedoussis, George, Martin, Nicholas G., Kiemeney, Lambertus A., Mooser, Vincent, Stefansson, Kari, Brent Richards, J., Becker, Tim, Brockschmidt, Felix F., Hinds, David A., Nöthen, Markus M.

“…The pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate…”
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Improving the detection of pathways in genome-wide association studies by combined effects of SNPs from Linkage Disequilibrium blocks by Zhao, Huiying, Nyholt, Dale R., Yang, Yuanhao, Wang, Jihua, Yang, Yuedong

“…Genome-wide association studies (GWAS) have successfully identified single variants associated with diseases. To increase the power of GWAS, gene-based and…”
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The search for genes contributing to endometriosis risk by Montgomery, Grant W., Nyholt, Dale R., Zhao, Zhen Zhen, Treloar, Susan A., Painter, Jodie N., Missmer, Stacey A., Kennedy, Stephen H., Zondervan, Krina T.

“…BACKGROUND Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the…”
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Association between endometriosis and the interleukin 1A (IL1A) locus by Sapkota, Yadav, Low, Siew-Kee, Attia, John, Gordon, Scott D., Henders, Anjali K., Holliday, Elizabeth G., MacGregor, Stuart, Martin, Nicholas G., McEvoy, Mark, Morris, Andrew P., Takahashi, Atsushi, Scott, Rodney J., Kubo, Michiaki, Zondervan, Krina T., Montgomery, Grant W., Nyholt, Dale R.

“…STUDY QUESTION Are single-nucleotide polymorphisms (SNPs) at the interleukin 1A (IL1A) gene locus associated with endometriosis risk? SUMMARY ANSWER We found…”
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A genome-wide association study of sleep habits and insomnia by Byrne, Enda M., Gehrman, Philip R., Medland, Sarah E., Nyholt, Dale R., Heath, Andrew C., Madden, Pamela A. F., Hickie, Ian B., Van Duijn, Cornelia M., Henders, Anjali K., Montgomery, Grant W., Martin, Nicholas G., Wray, Naomi R.

“…Several aspects of sleep behavior such as timing, duration and quality have been demonstrated to be heritable. To identify common variants that influence sleep…”
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Integrative multi-omic analysis identifies genetically influenced DNA methylation biomarkers for breast and prostate cancers by Sathyanarayanan, Anita, Tanha, Hamzeh M., Mehta, Divya, Nyholt, Dale R.

“…Aberrant DNA methylation has emerged as a hallmark in several cancers and contributes to risk, oncogenesis, progression, and prognosis. In this study, we…”
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Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine by Bainomugisa, Charlotte K., Sutherland, Heidi G., Parker, Richard, Mcrae, Allan F., Haupt, Larisa M., Griffiths, Lyn R., Heath, Andrew, Nelson, Elliot C., Wright, Margaret J., Hickie, Ian B., Martin, Nicholas G., Nyholt, Dale R., Mehta, Divya

“…Epigenetic mechanisms have been associated with genes involved in Posttraumatic stress disorder (PTSD). PTSD often co-occurs with other health conditions such…”
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