Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study

To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique Ngaliema, a public hospital, in Kinshasa, in the Democratic Republic of Congo (DRC). This retrospective study analyzed medical records including socio-demographics, past medical history, clinical manifestation,...

Full description

Saved in:

Bibliographic Details
Published in:	PloS one Vol. 15; no. 12; p. e0244272
Main Authors:	Matangila, Junior Rika, Nyembu, Ritha Kibambe, Telo, Gloire Mosala, Ngoy, Christian Djuba, Sakobo, Taty Msueun, Massolo, Joel Mbembo, Muyembe, Blandine Mbo, Mvwala, Richard Kapela, Ilunga, Cedric Kabemba, Limbole, Emmanuel Bakilo, Ntalaja, Jeff Mukengeshay, Kongo, Roger Minga
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 18-12-2020 Public Library of Science (PLoS)
Subjects:	Adult Age Aged Biology and life sciences Blood Coagulation Chloroquine Chloroquine - administration & dosage Chloroquine - analogs & derivatives Cohort analysis Coinfection Comorbidity Coronaviruses Cough COVID-19 COVID-19 - complications COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 Drug Treatment Democratic Republic of the Congo - epidemiology Demographics Demography Diabetes mellitus Epidemics Epidemiology Female Fever Health services Heart rate Hospitalization Hospitals Hospitals, Public Humans Hydroxychloroquine Hydroxychloroquine - administration & dosage Hypertension Infections Inflammation Laboratories Liver Function Tests Malaria Malaria - complications Male Medical records Medical research Medical treatment Medicine and Health Sciences Middle Aged Myalgia Oxygen saturation Patients Physical Sciences Public health Regression Analysis Regression models Retrospective Studies Risk analysis Risk Factors Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Signs and symptoms Social Class Tachycardia Tachycardia - complications Vector-borne diseases Viral diseases Democratic Republic of the Congo Congo (Kinshasa) United States > US Europe
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To describe the clinical characteristics of patients infected with SARS-CoV-2 at Clinique Ngaliema, a public hospital, in Kinshasa, in the Democratic Republic of Congo (DRC). This retrospective study analyzed medical records including socio-demographics, past medical history, clinical manifestation, comorbidities, laboratory data, treatment and disease outcome of 160 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection. The median age of patients was 54 years (IQR: 38-64), and there was no significant gender difference (51% of male). The most common comorbidities were hypertension (55 [34%]), diabetes (31 [19%]) and obesity (13 [8%]). Fever (93 [58%]), cough (92 [57%]), fatigue (87 [54%]), shortness of breath (72 [45%]) and myalgia (33 [21%]) were the most common symptoms, upon admission. Patients were categorized into mild (92 [57%]), moderate (19 [12%]) and severe (49 [31%]). Severe patients were older and were more likely to have comorbidities, compared to mild ones. The majority of patients (92% [147 of 160]) patients received hydroxychloroquine or chloroquine phosphate. Regression model revealed that older age, lower SpO2, higher heart rate and elevated AST at admission were all risk factors associated with in-hospital death. The prevalence of COVID-19 and malaria co-infection was 0.63% and 70 (44%) of all patients received antimalarial treatment before hospitalization. Our findings indicated that the epidemiological and clinical feature of COVID-19 patients in Kinshasa are broadly similar to previous reports from other settings. Older age, lower SpO2, tachycardia, and elevated AST could help to identify patients at higher risk of death at an early stage of the illness. Plasmodium spp co-infection was not common in hospitalized COVID-19 patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0244272