Search Results - "Nye, Jeffrey S."

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis by Tobe, Brian T. D., Crain, Andrew M., Winquist, Alicia M., Calabrese, Barbara, Makihara, Hiroko, Zhao, Wen-ning, Lalonde, Jasmin, Nakamura, Haruko, Konopaske, Glenn, Sidor, Michelle, Pernia, Cameron D., Yamashita, Naoya, Wada, Moyuka, Inoue, Yuuka, Nakamura, Fumio, Sheridan, Steven D., Logan, Ryan W., Brandel, Michael, Wu, Dongmei, Hunsberger, Joshua, Dorsett, Laurel, Duerr, Cordulla, Basa, Ranor C. B., McCarthy, Michael J., Udeshi, Namrata D., Mertins, Philipp, Carr, Steven A., Rouleau, Guy A., Mastrangelo, Lina, Li, Jianxue, Gutierrez, Gustavo J., Brill, Laurence M., Venizelos, Nikolaos, Chen, Guang, Nye, Jeffrey S., Manji, Husseini, Price, Jeffrey H., McClung, Colleen A., Akiskal, Hagop S., Alda, Martin, Chuang, De-Maw M., Coyle, Joseph T., Liu, Yang, Teng, Yang D., Ohshima, Toshio, Mikoshiba, Katsuhiko, Sidman, Richard L., Halpain, Shelley, Haggarty, Stephen J., Goshima, Yoshio, Snyder, Evan Y.

“…The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in…”
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Topiramate for Migraine Prevention in Adolescents: A Pooled Analysis of Efficacy and Safety by Winner, Paul, Gendolla, Astrid, Stayer, Catherine, Wang, Steven, Yuen, Eric, Battisti, Wendy P., Nye, Jeffrey S.

“…Objective.—To characterize the efficacy and safety of topiramate for migraine prevention in adolescents from 3 randomized, 26‐week, double‐blind,…”
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Long-Term Open-Label Study of Adjunctive Topiramate in Infants With Refractory Partial-Onset Seizures by Puri, Vinay, Ness, Seth, Sattaluri, Sita Jayalakshmi, Wang, Steven, Todd, Mike, Yuen, Eric, Eerdekens, Marielle, Nye, Jeffrey S., Manitpisitkul, Prasarn, Shalayda, Kevin, Ford, Lisa

“…Data from 2 studies (phase 1 and phase 3) in infants <2 years old (N = 284; mean [SD] age, 12[6.3] months) with refractory partial-onset seizures were pooled…”
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Adaptive Behavior Outcomes in Infants Treated With Adjunctive Topiramate by Ness, Seth, MD, PhD, FAAP, Todd, Mike J., MS, Wang, Steven, PhD, Eerdekens, Marielle, MD, MBA, Nye, Jeffrey S., MD, PhD, Ford, Lisa, MD

“…Abstract Data from two global studies (6-week open-label, phase 1 study; 20-day double-blind, phase 3 study) and their 1-year open-label extensions were pooled…”
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Intracellular Retention of Caveolin 1 in Presenilin-deficient Cells by Wood, Douglas R., Nye, Jeffrey S., Lamb, Ned J.C., Fernandez, Anne, Kitzmann, Magali

“…Mutations in genes encoding presenilins (PS1 and PS2) are responsible for the majority of early onset familial Alzheimer's disease. PS, a critical component of…”
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Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain by Gaiano, Nicholas, Nye, Jeffrey S., Fishell, Gord

“…In vertebrates, Notch signaling is generally thought to inhibit neural differentiation. However, whether Notch can also promote specific early cell fates in…”
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Alzheimer's disease research and development: a call for a new research roadmap by Feldman, Howard H., Haas, Magali, Gandy, Sam, Schoepp, Darryle D., Cross, Alan J., Mayeux, Richard, Sperling, Reisa A., Fillit, Howard, van de Hoef, Diana L., Dougal, Sonya, Nye, Jeffrey S.

“…Epidemiological projections of the prevalence of Alzheimer's disease (AD) and related dementias, the rapidly expanding population over the age of 65, and the…”
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Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells by Hitoshi, Seiji, Alexson, Tania, Tropepe, Vincent, Donoviel, Dorit, Elia, Andrew J, Nye, Jeffrey S, Conlon, Ronald A, Mak, Tak W, Bernstein, Alan, van der Kooy, Derek

“…Neural stem cells, which exhibit self-renewal and multipotentiality, are generated in early embryonic brains and maintained throughout the lifespan. The…”
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Identification and Characterization of Presenilin-independent Notch Signaling by Berechid, Bridget E., Kitzmann, Magali, Foltz, Daniel R., Roach, Arthur H., Seiffert, Dietmar, Thompson, Lorin A., Olson, Richard E., Bernstein, Alan, Donoviel, Dorit B., Nye, Jeffrey S.

“…Presenilin (PS) proteins control the proteolytic cleavage that precedes nuclear access of the Notch intracellular domain. Here we observe that a partial…”
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Effects of galantamine in a 2-year, randomized, placebo-controlled study in Alzheimer's disease by Hager, Klaus, Baseman, Alan S, Nye, Jeffrey S, Brashear, H Robert, Han, John, Sano, Mary, Davis, Bonnie, Richards, Henry M

“…Currently available treatments for Alzheimer's disease (AD) can produce mild improvements in cognitive function, behavior, and activities of daily living in…”
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Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1 by Carter, Donald B, Dunn, Edwige, Pauley, Adele M, McKinley, Denise D, Fleck, Timothy J, Ellerbrook, Brenda R, Stratman, Nancy C, Zhou, Xiangdong, Himes, Carol S, Nye, Jeffrey S, Tomasselli, Alfredo, Yan, Riqiang

“…Presenilin (PS1 or PS2) is an essential component of the active gamma-secretase complex that liberates the Abeta peptides from amyloid precursor protein (APP)…”
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Effect of concomitant use of memantine on mortality and efficacy outcomes of galantamine-treated patients with Alzheimer's disease: post-hoc analysis of a randomized placebo-controlled study by Hager, Klaus, Baseman, Alan S, Nye, Jeffrey S, Brashear, H Robert, Han, John, Sano, Mary, Davis, Bonnie, Richards, Henry M

“…A large, prospective, 2-year, randomized study in patients with mild-to-moderate Alzheimer's disease or mixed dementia demonstrated reductions in mortality and…”
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Pharmacokinetic–pharmacodynamic assessment of topiramate dosing regimens for children with epilepsy 2 to <10 years of age by Girgis, Ihab G., Nandy, Partha, Nye, Jeffrey S., Ford, Lisa, Mohanty, Surya, Wang, Steven, Ochalski, Stefan, Eerdekens, Marielle, Cox, Eugène

“…Summary Purpose:  To identify and validate the efficacious monotherapy dosing regimen for topiramate in children aged 2 to <10 years with newly diagnosed…”
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Modeling complex neuropsychiatric disorders with human induced pluripotent stem cells by Tobe, Brian TD, Snyder, Evan Y, Nye, Jeffrey S

“…Highlights ► Differentiated iPS lines from neuropsychiatric disease show neuronal abnormalities. ► Neuritic, synaptic and gene expression defects arise in…”
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Evaluation of JNJ-26489112 in patients with photosensitive epilepsy: A placebo-controlled, exploratory study by Di Prospero, Nicholas A, Gambale, Jay J, Pandina, Gahan, Ford, Lisa, Girgis, Suzette, Moyer, John A, Xi, Liwen, Nye, Jeffrey S, Kasteleijn-Nolst Trenité, Dorothée

“…Highlights • We evaluated activity of JNJ-26489112 in photosensitive epilepsy model. • Positive response was seen at all dose levels (1000-, 2000- and…”
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Implications and limitations of cellular reprogramming for psychiatric drug development by Tobe, Brian T D, Brandel, Michael G, Nye, Jeffrey S, Snyder, Evan Y

“…Human-induced pluripotent stem cells (hiPSCs) derived from somatic cells of patients have opened possibilities for in vitro modeling of the physiology of…”
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The effect of galantamine on brain atrophy rate in subjects with mild cognitive impairment is modified by apolipoprotein E genotype: post-hoc analysis of data from a randomized controlled trial by Prins, Niels D, van der Flier, Wiesje A, Knol, Dirk L, Fox, Nick C, Brashear, H Robert, Nye, Jeffrey S, Barkhof, Frederik, Scheltens, Philip

“…The aim of this investigation was to assess the effect of galantamine, an acetylcholinesterase inhibitor and allosteric modulator of nicotinic receptors, on…”
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Signal Transduction by Activated mNotch: Importance of Proteolytic Processing and its Regulation by the Extracellular Domain by Kopan, Raphael, Schroeter, Eric H., Weintraub, Harold, Nye, Jeffrey S.

“…Previous studies imply that the intracellular domain of Notch 1 must translocate to the nucleus for its activity. In this study, we demonstrate that a mNotch 1…”
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Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors by Chambers, C B, Peng, Y, Nguyen, H, Gaiano, N, Fishell, G, Nye, J S

“…The olfactory bulb, neocortex and archicortex arise from a common pool of progenitors in the dorsal telencephalon. We studied the consequences of supplying…”
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The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD by KOPAN, R, NYE, J. S, WEINTRAUB, H

“…We show that Myf-5 and mNotch mRNA are both present in the presomitic mesoderm before muscle cell commitment and before muscle structural gene activation. The…”
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