Search Results - "Nyce, Jonathan"

Detection of a novel, primate-specific ‘kill switch’ tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53 by Nyce, Jonathan W

“…The activation of TP53 is well known to exert tumor suppressive effects. We have detected a primate-specific adrenal androgen-mediated tumor suppression system…”
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244 Novel respirable antisense oligonucleotide (RASON) approach to primary and metastatic human lung cancer: preliminary results in a model system employing spontaneous lung tumors in dogs by Nyce, Jonathan

“…BackgroundAntisense oligonucleotides function by targeting the messenger RNA coding for a target protein, rather than the protein itself. This laboratory…”
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Species-specific mechanisms of tumor suppression are fundamental drivers of vertebrate speciation: critical implications for the ‘war on cancer’ by Nyce, Jonathan W

“…We recently reported our detection of an anthropoid primate-specific, ‘kill switch’ tumor suppression system that reached its greatest expression in humans,…”
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Enhanced echocardiographic assessment of intracardiac flow in congenital heart disease by Meyers, Brett A, Zhang, Jiacheng, Nyce, Jonathan, Loke, Yue-Hin, Vlachos, Pavlos P

“…4D flow magnetic resonance imaging (4D flow MRI) can assess and measure the complex flow patterns of the right ventricle (RV) in congenital heart diseases, but…”
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Predicting Need for Allogeneic Transfusion After Total Knee Arthroplasty by Noticewala, Manish S., BA, Nyce, Jonathan D., BS, Wang, Wenbao, MD, Geller, Jeffrey A., MD, Macaulay, William, MD

“…Abstract Total knee arthroplasty (TKA) can lead to substantial blood loss. To avoid the high costs of autologous blood predonation programs and efficiently…”
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Health-related quality of life in Hodgkin lymphoma: a systematic review by Linendoll, Nadine, Saunders, Tully, Burns, Rebecca, Nyce, Jonathan D, Wendell, Kristen B, Evens, Andrew M, Parsons, Susan K

“…Hodgkin Lymphoma (HL) is highly curable with well-established treatment regimens; however, the impact on patient's health-related quality of life (HRQL) from…”
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Sensitivity and Specificity of 2 Autism Screeners Among Referred Children Between 16 and 48 Months of Age by Salisbury, Louisa A, Nyce, Jonathan D, Hannum, Charles D, Sheldrick, R Christopher, Perrin, Ellen C

“…Autism screening is recommended by the American Academy of Pediatrics and the Centers for Disease Control and Prevention at ages 18 and 24 months. Popular…”
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Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition by Nyce, Jonathan W.

“…Glucose-6-phosphate dehydrogenase (G6PD) is an oncoprotein that is overexpressed in cancer cells to provide the NADPH required for their increased anabolism…”
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Early adverse results with bicompartmental knee arthroplasty: a prospective cohort comparison to total knee arthroplasty by Morrison, Todd A, Nyce, Jonathan D, Macaulay, William B, Geller, Jeffrey A

“…This prospective cohort study compares functional outcomes of bicompartmental knee arthroplasty (BKA) and total knee arthroplasty (TKA) in patients with…”
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Alert to US physicians: DHEA, widely used as an OTC androgen supplement, may exacerbate COVID-19 by Nyce, Jonathan

“…Androgens play a fundamental role in the morbidity and mortality of COVID-19, inducing both the ACE-2 receptor to which SARS-CoV-2 binds to gain entry into the…”
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Does Ipsilateral Knee Pain Improve after Hip Arthroplasty? by Wang, Wenbao, Geller, Jeffrey A., Nyce, Jonathan D., Choi, Jung Keun, Macaulay, William

“…Background Intraarticular hip disease is commonly acknowledged as a cause of ipsilateral knee pain. However, this is based primarily on observational rather…”
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Respirable antisense oligonucleotides: a new drug class for respiratory disease by Tanaka, M, Nyce, J W

“…Respirable antisense oligonucleotides (RASONs), which attenuate specific disease-associated mRNAs, represent a new class of respiratory therapeutics with…”
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The Accuracy and Reliability of Preoperative Templating for Metal-on-Metal Hip Resurfacing by Choi, Jung Keun, MD, Geller, Jeffrey A., MD, Wang, Wenbao, MD, Nyce, Jonathan D., BS, Macaulay, William, MD

“…Abstract The purposes of this study were to evaluate the accuracy and reliability of preoperative templating on conventional radiographs (CRs) for…”
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Hip Resurfacing is Less Painful at 24 Hours than Hip Replacement by Yoon, Richard S., MD, Geller, Jeffrey A., MD, Nyce, Jonathan D., BS, Morrison, Todd A., BS, Macaulay, William, MD

“…This article quantifies pain differences in the immediate postoperative period between patients undergoing total hip arthroplasty (THA) and metal-on-metal hip…”
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A lex naturalis delineates components of a human-specific, adrenal androgen-dependent, p53-mediated ‘kill switch’ tumor suppression mechanism by Nyce, Jonathan Wesley

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A lex naturalis delineates components of a human-specific, adrenal androgen-dependent, p53-mediated ‘kill switch’ tumor suppression mechanism by Nyce, Jonathan Wesley

“…We have recently described in this journal our detection of an anthropoid primate-specific, adrenal androgen-dependent, p53-mediated, ‘kill switch’ tumor…”
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Insight into adenosine receptor function using antisense and gene- knockout approaches by Nyce, Jonathan W

“…The extensive role of adenosine in discriminating input from the extracellular environment is effected through a series of cell membrane-spanning proteins –…”
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Early Adverse Results with Bicompartmental Knee Arthroplasty by Morrison, Todd A., MS, Nyce, Jonathan D., BS, Macaulay, William B., MD, Geller, Jeffrey A., MD

“…Abstract This prospective cohort study compares functional outcomes of bicompartmental knee arthroplasty (BKA) and total knee arthroplasty (TKA) in patients…”
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DNA antisense therapy for asthma in an animal model by Nyce, Jonathan W, Metzger, W. James

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Absorption, distribution, metabolism, and excretion of a respirable antisense oligonucleotide for asthma by ALI, Shahid, LEONARD, Sherry A, KUKOLY, Cindy A, METZGER, W. James, WOOLES, Wallace R, MCGINTY, Jacqueline F, TANAKA, Makoto, SANDRASAGRA, Anthony, NYCE, Jonathan W

“…EPI-2010 is a respirable antisense oligonucleotide (RASON), which selectively attenuates discordantly overexpressed adenosine A(1) receptors in allergic lung…”
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