Search Results - "Nyborg, Jens"

Structural Basis of the Action of Pulvomycin and GE2270 A on Elongation Factor Tu by Parmeggiani, Andrea, Krab, Ivo M, Okamura, Sumio, Nielsen, Rikke C, Nyborg, Jens, Nissen, Poul

“…Pulvomycin inhibits protein synthesis by preventing the formation of the ternary complex between elongation factor Tu (EF-Tu)·GTP and aa-tRNA. In this work,…”
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Bacterial Polypeptide Release Factor RF2 Is Structurally Distinct from Eukaryotic eRF1 by Vestergaard, Bente, Van, Lan Bich, Andersen, Gregers R, Nyborg, Jens, Buckingham, Richard H, Kjeldgaard, Morten

“…Bacterial release factor RF2 promotes termination of protein synthesis, specifically recognizing stop codons UAA or UGA. The crystal structure of Escherichia…”
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The Structure of Bovine Complement Component 3 Reveals the Basis for Thioester Function by Fredslund, Folmer, Jenner, Lasse, Husted, Lise B., Nyborg, Jens, Andersen, Gregers Rom, Sottrup-Jensen, Lars

“…The third component of complement (C3) is a 190 kDa glycoprotein essential for eliciting the complement response. The protein consists of two polypeptide…”
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Enacyloxin IIa Pinpoints a Binding Pocket of Elongation Factor Tu for Development of Novel Antibiotics by Parmeggiani, Andrea, Krab, Ivo M., Watanabe, Toshihiko, Nielsen, Rikke C., Dahlberg, Caroline, Nyborg, Jens, Nissen, Poul

“…Elongation factor (EF-) Tu·GTP is the carrier of aminoacyl-tRNA to the programmed ribosome. Enacyloxin IIa inhibits bacterial protein synthesis by hindering…”
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The GTP binding motif: variations on a theme by Kjeldgaard, M, Nyborg, J, Clark, B F

“…GTP binding proteins (G-proteins) have wide-ranging functions in biology, being involved in cell proliferation, signal transduction, protein synthesis, and…”
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The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation by Kjeldgaard, M, Nissen, P, Thirup, S, Nyborg, J

“…Elongation factor Tu (EF-Tu) is a GTP-binding protein that is crucial for protein biosynthesis. In the GTP form of the molecule, EF-Tu binds tightly to…”
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Helix unwinding in the effector region of elongation factor EF-Tu–GDP by Polekhina, Galina, Thirup, Søren, Kjeldgaard, Morten, Nissen, Poul, Lippmann, Corinna, Nyborg, Jens

“…Background Elongation factor Tu (EF-Tu) in its GTP conformation is a carrier of aminoacylated tRNAs (aa-tRNAs) to the ribosomal A site during protein…”
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Refined structure of elongation factor EF-Tu from Escherichia coli by Kjeldgaard, M, Nyborg, J

“…The crystal structure of trypsin-modified elongation factor Tu from Escherichia coli, in complex with the cofactor guanosine diphosphate has been refined to a…”
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Dual-mode recognition of noncanonical tRNAsSer by seryl-tRNA synthetase in mammalian mitochondria by Chimnaronk, Sarin, Gravers Jeppesen, Mads, Suzuki, Tsutomu, Nyborg, Jens, Watanabe, Kimitsuna

“…The secondary structures of metazoan mitochondrial (mt) tRNAsSer deviate markedly from the paradigm of the canonical cloverleaf structure; particularly,…”
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Diverse bacterial genomes encode an operon of two genes, one of which is an unusual class-I release factor that potentially recognizes atypical mRNA signals other than normal stop codons by Baranov, Pavel V, Vestergaard, Bente, Hamelryck, Thomas, Gesteland, Raymond F, Nyborg, Jens, Atkins, John F

“…While all codons that specify amino acids are universally recognized by tRNA molecules, codons signaling termination of translation are recognized by proteins…”
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Thermal stability of aminoacyl-tRNAs in aqueous solutions by STEPANOV, Victor G, NYBORG, Jens

“…Life in hot environments poses certain constraints on the metabolism of thermophilic organisms. Many universal metabolic intermediates are quite labile…”
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The ternary complex of EF-Tu and its role in protein biosynthesis by Clark, Brian FC, Nyborg, Jens

“…The past year has seen a breakthrough in our structural understanding of how aminoacyl-tRNAs are selected and transported to the ribosomal A-site in order to…”
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tmRNA from Thermus thermophilus by Stepanov, Victor G, Nyborg, Jens

“…The interaction of a Thermus thermophilus tmRNA transcript with alanyl‐tRNA synthetase and elongation factor Tu has been studied. The synthetic tmRNA was found…”
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The crystal structure of Cys-tRNACys-EF-Tu-GDPNP reveals general and specific features in the ternary complex and in tRNA by Nissen, P, Thirup, S, Kjeldgaard, M, Nyborg, J

“… The translation elongation factor EF-Tu in its GTP-bound state forms a ternary complex with any aminoacylated tRNA (aa-tRNA), except initiator tRNA and…”
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Elongation factors in protein biosynthesis by Andersen, Gregers R, Nissen, Poul, Nyborg, Jens

“…Translation elongation factors are the workhorses of protein synthesis on the ribosome. They assist in elongating the nascent polypeptide chain by one amino…”
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Mapping Escherichia coli Elongation Factor Tu Residues Involved in Binding of Aminoacyl-tRNA by Wiborg, Ove, Andersen, Carsten, Knudsen, Charlotte R., Clark, Brian F.C., Nyborg, Jens

“…Two residues of Escherichia coli elongation factor Tu involved in binding of aminoacyl-tRNA were identified and subjected to mutational analysis. Lys-89 and…”
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Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria by Chimnaronk, Sarin, Gravers Jeppesen, Mads, Suzuki, Tsutomu, Nyborg, Jens, Watanabe, Kimitsuna

“…The secondary structures of metazoan mitochondrial (mt) tRNAs(Ser) deviate markedly from the paradigm of the canonical cloverleaf structure; particularly,…”
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Crystal Structure of the Ternary Complex of Phe-tRNA$^{Phe}$, EF-Tu, and a GTP Analog by Nissen, Poul, Kjeldgaard, Morten, Thirup, Søren, Polekhina, Galina, Reshetnikova, Ludmila, Brian F. C. Clark, Nyborg, Jens

“…The structure of the ternary complex consisting of yeast phenylalanyl-transfer RNA (Phe-tRNA$^{Phe}$), Thermus aquaticus elongation factor Tu (EF-Tu), and the…”
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Structural Basis for Nucleotide Exchange and Competition with tRNA in the Yeast Elongation Factor Complex eEF1A:eEF1Bα by Andersen, Gregers Rom, Pedersen, Lise, Valente, Louis, Chatterjee, Ishita, Kinzy, Terri Goss, Kjeldgaard, Morten, Nyborg, Jens

“…The crystal structure of a complex between the protein biosynthesis elongation factor eEF1A (formerly EF-1 alpha ) and the catalytic C terminus of its exchange…”
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Crystal structure of the ternary complex of the Phe-tRNAPhe, EF-Tu, and a GTP analog by NISSEN, P, KJELDGAARD, M, THIRUP, S, POLEKHINA, G, RESHETNIKOVA, L, CLARK, B. F. C, NYBORG, J

“…The structure of the ternary complex consisting of yeast phenylalanyl-transfer RNA (Phe-tRNAPhe), Thermus aquaticus elongation factor Tu (EF-Tu), and the…”
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