Search Results - "Nyborg, Andrew"

Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis by Klint, Susanne, Feldwisch, Joachim, Gudmundsdotter, Lindvi, Dillner Bergstedt, Karin, Gunneriusson, Elin, Höidén Guthenberg, Ingmarie, Wennborg, Anders, Nyborg, Andrew C, Kamboj, Amol P, Peloso, Paul M, Bejker, David, Frejd, Fredrik Y

“…Psoriasis, an immune-mediated inflammatory disease, affects nearly 125 million people globally. The interleukin (IL)-17A homodimer is a key driver of psoriasis…”
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Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk by Feaver, Ryan E, Bowers, M. Scott, Cole, Banumathi K, Hoang, Steve, Lawson, Mark J, Taylor, Justin, LaMoreaux, Brian D, Zhao, Lin, Henke, Brad R, Johns, Brian A, Nyborg, Andrew C, Wamhoff, Brian R, Figler, Robert A

“…Some health concerns are often not identified until late into clinical development of drugs, which can place participants and patients at significant risk. For…”
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A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties by Nyborg, Andrew C, Ward, Chris, Zacco, Anna, Chacko, Benoy, Grinberg, Luba, Geoghegan, James C, Bean, Ryan, Wendeler, Michaela, Bartnik, Frank, O'Connor, Ellen, Gruia, Flaviu, Iyer, Vidyashankara, Feng, Hui, Roy, Varnika, Berge, Mark, Miner, Jeffrey N, Wilson, David M, Zhou, Dongmei, Nicholson, Simone, Wilker, Clynn, Wu, Chi Y, Wilson, Susan, Jermutus, Lutz, Wu, Herren, Owen, David A, Osbourn, Jane, Coats, Steven, Baca, Manuel

“…Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans…”
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Pegloticase co-administered with high MW polyethylene glycol effectively reduces PEG-immunogenicity and restores prolonged circulation in mouse by Li, Zhongbo, Shen, Limei, Ma, Alice, Talkington, Anne, Li, Zibo, Nyborg, Andrew C., Bowers, M. Scott, LaMoreaux, Brian, Livingston, Eric W., Frank, Jonathan E., Yuan, Hong, Lai, Samuel K.

“…The interactions between polymers and the immune system remains poorly controlled. In some instances, the immune system can produce antibodies specific to…”
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High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies by Talkington, Anne M., McSweeney, Morgan D., Zhang, Tao, Li, Zibo, Nyborg, Andrew C., LaMoreaux, Brian, Livingston, Eric W., Frank, Jonathan E., Yuan, Hong, Lai, Samuel K.

“…Pegloticase is an enzyme used to reduce serum uric acid levels in patients with chronic, treatment-refractory gout. Clinically, about 40% of patients develop…”
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Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells by Nyborg, Andrew C, Zacco, Anna, Ettinger, Rachel, Jack Borrok, M, Zhu, Jie, Martin, Tom, Woods, Rob, Kiefer, Christine, Bowen, Michael A, Suzanne Cohen, E., Herbst, Ronald, Wu, Herren, Coats, Steven

“…Immunoglobulin E （IgE） plays a key role in allergic asthma and is a clinically validated target for monoclonal antibodies. Therapeutic anti-lgE antibodies…”
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A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells by Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Zhang, Zhifen, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Melnyk, Roman A., Spiller, Benjamin W., Lacy, D. Borden

“…Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is mediated by the actions of two toxins, TcdA and TcdB. The toxins…”
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Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface by Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Ohi, Melanie D., Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Spiller, Benjamin W., Lacy, D. Borden

“…Clostridium difficile is a clinically significant pathogen that causes mild-to-severe (and often recurrent) colon infections. Disease symptoms stem from the…”
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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains by Wahrle, Suzanne, Das, Pritam, Nyborg, Andrew C., McLendon, Chris, Shoji, Mikio, Kawarabayashi, Takeshi, Younkin, Linda H., Younkin, Steven G., Golde, Todd E.

“…Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the γ-secretase complex, and APP CTFβ, a γ-secretase substrate, can be…”
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Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates by Nyborg, Andrew C, Ladd, Thomas B, Zwizinski, Craig W, Lah, James J, Golde, Todd E

“…The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo…”
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C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation by Wang, Jun, Beher, Dirk, Nyborg, Andrew C., Shearman, Mark S., Golde, Todd E., Goate, Alison

“…The Alzheimer's disease‐associated β‐amyloid peptide is produced through cleavage of amyloid precursor protein by β‐secretase and γ‐secretase. γ‐Secretase is a…”
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Signal Peptide Peptidase:  Biochemical Properties and Modulation by Nonsteroidal Antiinflammatory Drugs by Sato, Toru, Nyborg, Andrew C, Iwata, Nobuhisa, Diehl, Thekla S, Saido, Takaomi C, Golde, Todd E, Wolfe, Michael S

“…Signal peptide peptidase (SPP) is an intramembrane aspartyl protease that cleaves remnant signal peptides after their release by signal peptidase. SPP contains…”
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Flavodoxin Hydroquinone Reduces Azotobacter vinelandii Fe Protein to the All-Ferrous Redox State with a S = 0 Spin State by Lowery, Thomas J., Wilson, Phillip E., Zhang, Bo, Bunker, Jared, Harrison, Roger G., Nyborg, Andrew C., Thiriot, David, Watt, Gerald D.

“…Azotobacter vinelandii flavodoxin hydroquinone (FIdHQ) is a physiological reductant to nitrogenase supporting catalysis that is twice as energy efficient…”
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Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase by Nyborg, Andrew C, Ladd, Thomas B, Jansen, Karen, Kukar, Thomas, Golde, Todd E

“…Signal peptide peptidase (SPP) is an intramembrane cleaving protease (I-CLiP) identified by its cleavage of several type II membrane signal peptides. To date,…”
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In vivo and ex vivo imaging of amyloid-β cascade aggregates with a Pronucleon™ peptide by Nyborg, Andrew C, Moll, Jonathan R, Wegrzyn, Renee D, Havas, Daniel, Hutter-Paier, Birgit, Feuerstein, Giora G Z, Rudolph, Alan S

“…Accumulation of amyloid-β (Aβ) cascade aggregates is considered a hallmark of Alzheimer's disease (AD). Current dogma holds that the appearance of Aβ oligomers…”
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Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor by Nyborg, Andrew C., Kornilova, Anna Y., Jansen, Karen, Ladd, Thomas B., Wolfe, Michael S., Golde, Todd E.

“…Presenilin (PS) is the presumptive catalytic component of the intramembrane aspartyl protease γ-secretase complex. Recently a family of presenilin homologs was…”
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A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin by Nyborg, Andrew C, Jansen, Karen, Ladd, Thomas B, Fauq, Abdul, Golde, Todd E

“…Signal peptide peptidase (SPP) is an intramembrane-cleaving protease identified by its cleavage of several type II membrane signal peptides after signal…”
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Targeting the junction of CɛmX and ɛ-migis for the specific depletion of mIgE-expressing B cells by Chowdhury, Partha S., Chen, Yan, Yang, Chunning, Cook, Kimberly E., Nyborg, Andrew C., Ettinger, Rachel, Herbst, Ronald, Kiener, Peter A., Wu, Herren

“…► Human antibodies from phage library against membrane form of IgE (mIgE) on B-cells. ► Antibodies bind to mIgE in the context of CD79a and CD79b. ► Antibodies…”
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Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells by Nyborg, Andrew C, Herl, Lauren, Berezovska, Oksana, Thomas, Anne V, Ladd, Thomas B, Jansen, Karen, Hyman, Bradley T, Golde, Todd E

“…Signal peptide peptidase (SPP) is an intramembrane cleaving protease identified by its cleavage of several type II membrane signal peptides. Conservation of…”
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Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy by Herl, Lauren, Lleo, Alberto, Thomas, Anne V., Nyborg, Andrew C., Jansen, Karen, Golde, Todd E., Hyman, Bradley T., Berezovska, Oksana

“…Presenilin-1 (PS1) is a multipass transmembrane domain protein, which is believed to be the catalytic component of the γ-secretase complex. The complex is…”
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