Challenges in the treatment and prevention of monkeypox infection; A comprehensive review

•The article discusses the epidemiology, etiology, treatment and prevention of monkeypox virus in detail.•The clinical manifestation, pathophysiology, transmission of the infection is represented as a figure for easy understanding.•The diagnosis of infection is discussed in detail in a table.•Comple...

Full description

Saved in:

Bibliographic Details
Published in:	Acta tropica Vol. 245; p. 106960
Main Authors:	Nyame, Jennifer, Punniyakotti, Saranya, Khera, Kanav, Pal, Rashmi Saxena, Varadarajan, Nithya, Sharma, Prachi
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-09-2023 Published by Elsevier B.V
Subjects:	Animals Brincidofovir Cidofovir COVID-19 Epidemiology Human monkeypox Humans Monkeypox virus Mpox (monkeypox) - epidemiology Mpox (monkeypox) - prevention & control Pathogenesis Smallpox Vaccine Tecovirimat Zoonoses - epidemiology Zoonoses - prevention & control Zoonotic Human monkeypox Pathogenesis Tecovirimat Zoonotic Cidofovir Brincidofovir Epidemiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	•The article discusses the epidemiology, etiology, treatment and prevention of monkeypox virus in detail.•The clinical manifestation, pathophysiology, transmission of the infection is represented as a figure for easy understanding.•The diagnosis of infection is discussed in detail in a table.•Complete information of the medicines used in the treatment of the infection, vaccines to prevent the infection is explained. Human monkeypox (HMPX) is a zoonotic disease, literally meaning that it can be passed on from animals (non-primate) to human (primate). All the reported and recorded cases have been traced back either to international travel or import of African animals. In the Unites states, sporadic monkeypox cases have been reported in specific over the past 50 years, starting its first identification in the Democratic Republic of the Congo (D.R.C.) in 1970. Due to its extreme versatility, this disease poses threat as a serious public health issue that needs to be monitored, researched and prevented. Data indicate that prior immunization with the smallpox vaccine is beneficial and may provide protection against the monkeypox virus. JYNNEOSTM is a live viral vaccine that has been approved to improve clinical manifestations of the infection. On the other hand, public ignorance about safety precaution towards monkeypox post-COVID is another challenge that needs to be overcome in tackling HMPX as a possible re-emergent infection. This review is a collation of the epidemiology, etiology, transmission, clinical features and treatment of human monkeypox (HMPX).
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0001-706X 1873-6254
DOI:	10.1016/j.actatropica.2023.106960