Ethnicity and breast cancer characteristics in Kenya

Ethnicity and breast cancer characteristics in Kenya

Purpose There are no published data from specific regions of sub-Saharan Africa describing the clinical and pathological characteristics and molecular subtypes of invasive breast cancer by ethnic group. The purpose of this study was to investigate these characteristics among the three major ethno-cu...

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Published in:Breast cancer research and treatment Vol. 167; no. 2; pp. 425 - 437
Main Authors: Sayed, Shahin, Moloo, Zahir, Wasike, Ronald, Bird, Peter, Oigara, Raymond, Njoroge, Faith Wambui, Shaikh, Asim Jamal, Prasad, Satya Vara, Vinayak, Sudhir, Gierach, Gretchen L., Dawsey, Sanford M., Palakal, Maya, Fan, Shaoqi, Mullooly, Maeve, Chauhan, Rajendra, Okiro, Patricia, Gakinya, Samuel, Nzioka, Ancent, Kyobutungi, Catherine, Mohamed, Shukri, Haregu, Tilahun, Mussajee, Mustafa, Bonass, Betty, Mariwa, Costa, Sherman, Omar Ali, Mohammed, Abdihakim, Gachii, Andrew, Githaiga, Joseph, Karanu, Joseph, Nyagah, Robert, Njoroge, Richard, Muramba, Irene, Otieno, James Obondi, Raburu, Dan Omondi, Mwachiro, Elizabeth B., Abayo, Innocent, Saleh, Mansoor
Format: Journal Article
Language:English
Published: New York Springer US 01-01-2018
Springer
Springer Nature B.V
Subjects:
Analysis
Body weight
Breast cancer
Cancer research
ErbB-2 protein
Ethnicity
Immunohistochemistry
Invasiveness
Medicine
Medicine & Public Health
Menopause
Minority & ethnic groups
Oncology
Overweight
Preclinical Study
Sociodemographics
Statistical analysis
Surgery
Tumors
Kenya
Africa
Ethnicity
Breast cancer
Ethnic differences
Kenya
Sub-Saharan Africa
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Summary:Purpose There are no published data from specific regions of sub-Saharan Africa describing the clinical and pathological characteristics and molecular subtypes of invasive breast cancer by ethnic group. The purpose of this study was to investigate these characteristics among the three major ethno-cultural groupings in Kenya. Methods The study included women with pathologically confirmed breast cancer diagnosed between March 2012 and May 2015 at 11 hospitals throughout Kenya. Sociodemographic, clinical, and reproductive data were collected by questionnaire, and pathology review and immunohistochemistry were performed centrally. Results The 846 cases included 661 Bantus (78.1%), 143 Nilotes (16.9%), 19 Cushites (2.3%), and 23 patients of mixed ethnicity (2.7%). In analyses comparing the two major ethnic groups, Bantus were more educated, more overweight, had an older age at first birth, and had a younger age at menopause than Nilotes ( p  < 0.05 for all comparisons). In analyses restricted to definitive surgery specimens, there were no statistically significant differences in tumor characteristics or molecular subtypes by ethnicity, although the Nilote tumors tended to be larger (OR for ≥ 5 cm vs. < 2 cm: 3.86, 95% CI 0.77, 19.30) and were somewhat more likely to be HER2 enriched (OR for HER2 enriched vs. Luminal A/B: 1.41, 95% CI 0.79, 2.49). Conclusion This case series showed no significant differences in breast cancer tumor characteristics or molecular subtypes, but significant differences in sociodemographic characteristics and reproductive factors, among the three major ethnic groups in Kenya. We suggest further evaluation of ethnic differences in breast cancer throughout the genetically and culturally diverse populations of sub-Saharan Africa.
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ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-017-4511-2