Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats

Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. Cucumeropsis mannii seed is a common soup thickener that produces vegetable oil as well as essential nutrients...

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Bibliographic Details
Published in:	Heliyon Vol. 8; no. 3; p. e09162
Main Authors:	Agu, P.C., Aja, P.M., Ekpono Ugbala, Ezebuilo, Ogwoni, H.A., Ezeh, E.M., Oscar-Amobi, P.C., Asuk Atamgba, Agbor, Ani, O.G., Awoke, J.N., Nwite, F.E., Ukachi, O.U., Orji, O.U., Nweke, P.C., Ekpono Ugbala, Ejike, Ewa, G.O., Igwenyi, I.O., Egwu, C.O., Alum, E.U., Chukwu, D.C., Famurewa, A.C.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-03-2022 Elsevier
Subjects:	Bisphenol A Cucumeropsis mannii Nutraceuticals Testicular toxicity Bisphenol A Cucumeropsis mannii Testicular toxicity Nutraceuticals
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Summary:	Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. Cucumeropsis mannii seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity. Bisphenol A; Cucumeropsis mannii; Testicular toxicity; Nutraceuticals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2405-8440 2405-8440
DOI:	10.1016/j.heliyon.2022.e09162