Search Results - "Nwakanma, Davis C."

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity by Mobegi, Victor A, Duffy, Craig W, Amambua-Ngwa, Alfred, Loua, Kovana M, Laman, Eugene, Nwakanma, Davis C, MacInnis, Bronwyn, Aspeling-Jones, Harvey, Murray, Lee, Clark, Taane G, Kwiatkowski, Dominic P, Conway, David J

“…Locally varying selection on pathogens may be due to differences in drug pressure, host immunity, transmission opportunities between hosts, or the intensity of…”
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Population genetic structure of Plasmodium falciparum across a region of diverse endemicity in West Africa by Mobegi, Victor A, Loua, Kovana M, Ahouidi, Ambroise D, Satoguina, Judith, Nwakanma, Davis C, Amambua-Ngwa, Alfred, Conway, David J

“…Malaria parasite population genetic structure varies among areas of differing endemicity, but this has not been systematically studied across Plasmodium…”
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Quantitative Detection of Plasmodium falciparum DNA in Saliva, Blood, and Urine by Nwakanma, Davis C., Gomez-Escobar, Natalia, Walther, Michael, Crozier, Sarah, Dubovsky, Filip, Malkin, Elissa, Locke, Emily, Conway, David J.

“…BackgroundCurrent methods for detecting malaria parasites are invasive and associated with poor compliance when repeated sampling is required. New methods to…”
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Continued decline of malaria in The Gambia with implications for elimination by Ceesay, Serign J, Casals-Pascual, Climent, Nwakanma, Davis C, Walther, Michael, Gomez-Escobar, Natalia, Fulford, Anthony J C, Takem, Ebako N, Nogaro, Sarah, Bojang, Kalifa A, Corrah, Tumani, Jaye, Momodou Cherno, Taal, Makie Abdoulie, Sonko, Aja Adam Jagne, Conway, David J

“…A substantial decline in malaria was reported to have occurred over several years until 2007 in the western part of The Gambia, encouraging consideration of…”
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The "far-west" of Anopheles gambiae molecular forms by Caputo, Beniamino, Santolamazza, Federica, Vicente, José L, Nwakanma, Davis C, Jawara, Musa, Palsson, Katinka, Jaenson, Thomas, White, Bradley J, Mancini, Emiliano, Petrarca, Vincenzo, Conway, David J, Besansky, Nora J, Pinto, João, della Torre, Alessandra

“…The main Afrotropical malaria vector, Anopheles gambiae sensu stricto, is undergoing a process of sympatric ecological diversification leading to at least two…”
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Optimizing odor-baited trap methods for collecting mosquitoes during the malaria season in The Gambia by Jawara, M, Smallegange, R.C, Jeffries, D, Nwakanma, D.C, Awolola, T.S, Knols, B.G.J, Takken, W, Conway, D.J

“…Baited traps are potential tools for removal or surveillance of disease vectors. To optimize the use of counter-flow traps baited with human odor (nylon socks…”
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PfHPRT: A New Biomarker Candidate of Acute Plasmodium falciparum Infection by Thézénas, Marie L, Huang, Honglei, Njie, Madi, Ramaprasad, Abhinay, Nwakanma, Davis C, Fischer, Roman, Digleria, Katalin, Walther, Michael, Conway, David J, Kessler, Benedikt M, Casals-Pascual, Climent

“…Plasmodium falciparum is a protozoan parasite that causes human malaria. This parasitic infection accounts for approximately 655 000 deaths each year…”
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Dry season ecology of Anopheles gambiae complex mosquitoes in The Gambia by Jawara, Musa, Pinder, Margaret, Drakeley, Chris J, Nwakanma, Davis C, Jallow, Ebrima, Bogh, Claus, Lindsay, Steve W, Conway, David J

“…Malaria in The Gambia is highly seasonal, with transmission occurring as Anopheles gambiae s.l. populations expand during and immediately after a single annual…”
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Human saliva as a source of anti-malarial antibodies to examine population exposure to Plasmodium falciparum by Estévez, Patricia Tabernero, Satoguina, Judith, Nwakanma, Davis C, West, Sheila, Conway, David J, Drakeley, Chris J

“…Antibody responses to malaria antigens reflect exposure to parasites, and seroprevalence correlates with malaria transmission intensity. Antibodies are…”
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Prevention of the recurrence of anaemia in Gambian children following discharge from hospital by Bojang, Kalifa A, Milligan, Paul J M, Conway, David J, Sisay-Joof, Fatou, Jallow, Muminatou, Nwakanma, Davis C, Abubakr, Ismaela, Njie, Fanta, Greenwood, Brian

“…In malaria endemic countries, children who have experienced an episode of severe anaemia are at increased risk of a recurrence of anaemia. There is a need to…”
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Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials by Mahindra, Amit, Janha, Omar, Mapesa, Kopano, Sanchez-Azqueta, Ana, Alam, Mahmood M, Amambua-Ngwa, Alfred, Nwakanma, Davis C, Tobin, Andrew B, Jamieson, Andrew G

“…The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing and is essential for the survival of blood stage Plasmodium…”
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Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

“…Targeting parasite's protein kinaseMalaria elimination goals are constantly eroded by the challenge of emerging drug and insecticide resistance. Alam et al…”
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Development of Potent Pf CLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials by Mahindra, Amit, Janha, Omar, Mapesa, Kopano, Sanchez-Azqueta, Ana, Alam, Mahmood M, Amambua-Ngwa, Alfred, Nwakanma, Davis C, Tobin, Andrew B, Jamieson, Andrew G

“…The protein kinase CLK3 plays a critical role in the regulation of malarial parasite RNA splicing and is essential for the survival of blood stage . We…”
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Novel techniques and future directions in molecular diagnosis of malaria in resource-limited settings by Oriero, Eniyou Cheryll, Van Geertruyden, Jean-Pierre, Nwakanma, Davis C, D'Alessandro, Umberto, Jacobs, Jan

“…Despite being preventable and treatable, malaria remains a global health concern with approximately 1.2 billion people at high risk of being infected, 90% of…”
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Changes in Malaria Parasite Drug Resistance in an Endemic Population Over a 25-Year Period With Resulting Genomic Evidence of Selection by Nwakanma, Davis C., Duffy, Craig W., Amambua-Ngwa, Alfred, Oriero, Eniyou C., Bojang, Kalifa A., Pinder, Margaret, Drakeley, Chris J., Sutherland, Colin J., Milligan, Paul J., MacInnis, Bronwyn, Kwiatkowski, Dominic P., Clark, Taane G., Greenwood, Brian M., Conway, David J.

“…Background. Analysis of genome-wide polymorphism in many organisms has potential to identify genes under recent selection. However, data on historical allele…”
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Breakdown in the process of incipient speciation in Anopheles gambiae by Nwakanma, Davis C, Neafsey, Daniel E, Jawara, Musa, Adiamoh, Majidah, Lund, Emily, Rodrigues, Amabelia, Loua, Kovana M, Konate, Lassana, Sy, Ngayo, Dia, Ibrahima, Awolola, T Samson, Muskavitch, Marc A T, Conway, David J

“…Understanding genetic causes and effects of speciation in sympatric populations of sexually reproducing eukaryotes is challenging, controversial, and of…”
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Validation of the protein kinase Pf CLK3 as a multistage cross-species malarial drug target by Alam, Mahmood M, Sanchez-Azqueta, Ana, Janha, Omar, Flannery, Erika L, Mahindra, Amit, Mapesa, Kopano, Char, Aditya B, Sriranganadane, Dev, Brancucci, Nicolas M B, Antonova-Koch, Yevgeniya, Crouch, Kathryn, Simwela, Nelson Victor, Millar, Scott B, Akinwale, Jude, Mitcheson, Deborah, Solyakov, Lev, Dudek, Kate, Jones, Carolyn, Zapatero, Cleofé, Doerig, Christian, Nwakanma, Davis C, Vázquez, Maria Jesús, Colmenarejo, Gonzalo, Lafuente-Monasterio, Maria Jose, Leon, Maria Luisa, Godoi, Paulo H C, Elkins, Jon M, Waters, Andrew P, Jamieson, Andrew G, Álvaro, Elena Fernández, Ranford-Cartwright, Lisa C, Marti, Matthias, Winzeler, Elizabeth A, Gamo, Francisco Javier, Tobin, Andrew B

“…The requirement for next-generation antimalarials to be both curative and transmission-blocking necessitates the identification of previously undiscovered…”
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Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone by Santolamazza, Federica, Caputo, Beniamino, Nwakanma, Davis C, Fanello, Caterina, Petrarca, Vincenzo, Conway, David J, Weetman, David, Pinto, Joao, Mancini, Emiliano, della Torre, Alessandra

“…Genomic differentiation between Anopheles gambiae and Anopheles coluzzii--the major malaria vectors in sub-Saharan Africa--is localized into large "islands"…”
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Microsatellite markers reveal low levels of population sub-structuring of Plasmodium falciparum in southwestern Nigeria by Oyebola, Muyiwa K, Idowu, Emmanuel T, Nyang, Haddy, Olukosi, Yetunde A, Otubanjo, Olubunmi A, Nwakanma, Davis C, Awolola, Samson T, Amambua-Ngwa, Alfred

“…Genetic diversity studies provide evidence of Plasmodium falciparum differentiation that could affect fitness and adaptation to drugs and target antigens for…”
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Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii

“…Mosquito control remains a central pillar of efforts to reduce malaria burden in sub-Saharan Africa. However, insecticide resistance is entrenched in malaria…”
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