The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population

The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population

Acne vulgaris is a very common skin disorder affecting human beings. There is a paucity of report on the role of heavy metals—lead (Pb) and cadmium (Cd)—globally, and trace metals—zinc (Zn) and copper (Cd)—particularly in Nigeria in the development/severity of acne vulgaris. This study is aimed to d...

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Bibliographic Details
Published in:Biological trace element research Vol. 176; no. 2; pp. 251 - 257
Main Authors: Ikaraoha, C.I., Mbadiwe, N.C., Anyanwu, C.J., Odekhian, J., Nwadike, C.N., Amah, H.C.
Format: Journal Article
Language:English
Published: New York Springer US 01-04-2017
Springer Nature B.V
Subjects:
Acne
Acne Vulgaris - blood
Adolescent
Adult
Biochemistry
Biomedical and Life Sciences
Biotechnology
Blood levels
Cadmium
Cadmium - blood
Copper
Copper - blood
Female
Heavy metals
Humans
Lead
Lead - blood
Life Sciences
Nigeria
Nutrition
Oncology
Severity of Illness Index
Skin diseases
Trace metals
Young Adult
Zinc
Zinc - blood
Nigeria
Acne vulgaris
Lead
Cadmium
Copper
Nigeria
Zinc
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Summary:Acne vulgaris is a very common skin disorder affecting human beings. There is a paucity of report on the role of heavy metals—lead (Pb) and cadmium (Cd)—globally, and trace metals—zinc (Zn) and copper (Cd)—particularly in Nigeria in the development/severity of acne vulgaris. This study is aimed to determine the blood levels of some heavy metals—cadmium and lead—and trace metals—zinc and copper—in acne vulgaris sufferers in a Nigerian population. Venous blood samples were collected from a total number of 90 non-obese female subjects consisting of 30 mild, 30 moderate and 30 severe acne vulgaris sufferers for blood Cd, Pb, Cu and Zn determination. They were age-matched with 60 females without acne vulgaris who served as the control subjects. Acne sufferers had significantly higher blood Cd and Pb ( P  = 0.0143 and P  = 0.0001 respectively) and non-significantly different blood levels of Cu and Zn ( P  = 0.910 and P  = 0.2140 respectively) compared to controls. There were significant progressive increases in blood levels of Cd and Pb ( P  = 0.0330 and P  = 0.0001 respectively) and non-significant differences in the mean blood level of Cu and Zn ( P  = 0.1821 and P  = 0.2728 respectively) from mild to moderate and severe acne vulgaris sufferers. Increases in blood Cd and Pb may play critical roles in the pathogenesis/severity of acne vulgaris, while Cu and Zn seem to play less significant roles in the development of this disorder in this environment.
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ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-016-0839-4