Search Results - "Nuyten, Dimitry"

Concordance among Gene-Expression–Based Predictors for Breast Cancer by Fan, Cheng, Oh, Daniel S, Wessels, Lodewyk, Weigelt, Britta, Nuyten, Dimitry S.A, Nobel, Andrew B, van't Veer, Laura J, Perou, Charles M

“…There are now many published examples of gene-expression–based methods to aid in the determination of prognosis, and some of these methods are available to the…”
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interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer by Weichselbaum, Ralph R, Ishwaran, Hemant, Yoon, Taewon, Nuyten, Dimitry S.A, Baker, Samuel W, Khodarev, Nikolai, Su, Andy W, Shaikh, Arif Y, Roach, Paul, Kreike, Bas, Roizman, Bernard, Bergh, Jonas, Pawitan, Yudi, van de Vijver, Marc J, Minn, Andy J

“…Individualization of cancer management requires prognostic markers and therapy-predictive markers. Prognostic markers assess risk of disease progression…”
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Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers by Chi, Jen-Tsan, Wang, Zhen, Nuyten, Dimitry S A, Rodriguez, Edwin H, Schaner, Marci E, Salim, Ali, Wang, Yun, Kristensen, Gunnar B, Helland, Aslaug, Børresen-Dale, Anne-Lise, Giaccia, Amato, Longaker, Michael T, Hastie, Trevor, Yang, George P, van de Vijver, Marc J, Brown, Patrick O

“…Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important roles in normal physiology and in many human diseases. A transcription…”
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Robustness, Scalability, and Integration of a Wound-Response Gene Expression Signature in Predicting Breast Cancer Survival by Chang, Howard Y., Dimitry S. A. Nuyten, Sneddon, Julie B., Hastie, Trevor, Tibshirani, Robert, Sørlie, Therese, Dai, Hongyue, He, Yudong D., Laura J. van't Veer, Bartelink, Harry, van de Rijn, Matt, Brown, Patrick O., van de Vijver, Marc J.

“…Based on the hypothesis that features of the molecular program of normal wound healing might play an important role in cancer metastasis, we previously…”
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macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans by Welm, Alana L, Sneddon, Julie B, Taylor, Carmen, Nuyten, Dimitry S.A, van de Vijver, Marc J, Hasegawa, Bruce H, Bishop, J. Michael

“…A better understanding of tumor metastasis requires development of animal models that authentically reproduce the metastatic process. By modifying an existing…”
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Determination of stromal signatures in breast carcinoma by West, Robert B, Nuyten, Dimitry S A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, Montgomery, Kelli, Zhu, Shirley, Patel, Rajiv, Hernandez-Boussard, Tina, Goldblum, John R, Brown, Patrick O, van de Vijver, Marc, van de Rijn, Matt

“…Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of…”
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Predicting a local recurrence after breast-conserving therapy by gene expression profiling by Nuyten, Dimitry S A, Kreike, Bas, Hart, Augustinus A M, Chi, Jen-Tsan Ashley, Sneddon, Julie B, Wessels, Lodewyk F A, Peterse, Hans J, Bartelink, Harry, Brown, Patrick O, Chang, Howard Y, van de Vijver, Marc J

“…To tailor local treatment in breast cancer patients there is a need for predicting ipsilateral recurrences after breast-conserving therapy. After adequate…”
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Revealing Targeted Therapy for Human Cancer by Gene Module Maps by WONG, David J, NUYTEN, Dimitry S. A, REGEV, Aviv, MEIHONG LIN, ADLER, Adam S, SEGAL, Eran, VAN DE VIJVER, Marc J, CHANG, Howard Y

“…A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of…”
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Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers by Chi, Jen-Tsan, Rodriguez, Edwin H, Wang, Zhen, Nuyten, Dimitry S A, Mukherjee, Sayan, van de Rijn, Matt, van de Vijver, Marc J, Hastie, Trevor, Brown, Patrick O

“…Smooth muscle is present in a wide variety of anatomical locations, such as blood vessels, various visceral organs, and hair follicles. Contraction of smooth…”
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Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer by Buess, Martin, Nuyten, Dimitry S A, Hastie, Trevor, Nielsen, Torsten, Pesich, Robert, Brown, Patrick O

“…Perturbations in cell-cell interactions are a key feature of cancer. However, little is known about the systematic effects of cell-cell interaction on global…”
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Genetic regulators of large-scale transcriptional signatures in cancer by Chang, Howard Y, Adler, Adam S, Lin, Meihong, Horlings, Hugo, Nuyten, Dimitry S A, van de Vijver, Marc J

“…Gene expression signatures encompassing dozens to hundreds of genes have been associated with many important parameters of cancer, but mechanisms of their…”
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Local Recurrence after Breast-Conserving Therapy in Relation to Gene Expression Patterns in a Large Series of Patients by Kreike, Bas, Halfwerk, Hans, Armstrong, Nicola, Bult, Peter, Foekens, John A, Veltkamp, Sanne C, Nuyten, Dimitry S A, Bartelink, Harry, van de Vijver, Marc J

“…Purpose: The majority of patients with early-stage breast cancer are treated with breast-conserving therapy (BCT). Several clinical risk factors are associated…”
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Mouse Mammary Gland Involution mRNA Signature Identifies Biological Pathways Potentially Associated with Breast Cancer Metastasis by Stein, Torsten, Salomonis, Nathan, Nuyten, Dimitry S. A, van de Vijver, Marc J, Gusterson, Barry A

“…Mouse mammary gland involution resembles a wound healing response with suppressed inflammation. Wound healing and inflammation are also associated with tumour…”
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Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis by Sotiriou, Christos, Wirapati, Pratyaksha, Loi, Sherene, Harris, Adrian, Fox, Steve, Smeds, Johanna, Nordgren, Hans, Farmer, Pierre, Praz, Viviane, Haibe-Kains, Benjamin, Desmedt, Christine, Larsimont, Denis, Cardoso, Fatima, Peterse, Hans, Nuyten, Dimitry, Buyse, Marc, Van de Vijver, Marc J., Bergh, Jonas, Piccart, Martine, Delorenzi, Mauro

“…Background: Histologic grade in breast cancer provides clinically important prognostic information. However, 30%–60% of tumors are classified as histologic…”
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Lung metastasis genes couple breast tumor size and metastatic spread by Minn, Andy J, Gupta, Gaorav P, Padua, David, Bos, Paula, Nguyen, Don X, Nuyten, Dimitry, Kreike, Bas, Zhang, Yi, Wang, Yixin, Ishwaran, Hemant, Foekens, John A, van de Vijver, Marc, Massagué, Joan

“…The association between large tumor size and metastatic risk in a majority of clinical cancers has led to questions as to whether these observations are…”
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Integration of DNA Copy Number Alterations and Prognostic Gene Expression Signatures in Breast Cancer Patients by Horlings, Hugo M, Lai, Carmen, Nuyten, Dimitry S A, Halfwerk, Hans, Kristel, Petra, van Beers, Erik, Joosse, Simon A, Klijn, Christiaan, Nederlof, Petra M, Reinders, Marcel J T, Wessels, Lodewyk F A, van de Vijver, Marc J

“…Purpose: Several prognostic gene expression profiles have been identified in breast cancer. In spite of this progress in prognostic classification, the…”
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Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification by Nuyten, Dimitry S.A, Hastie, Trevor, Chi, Jen-Tsan Ashley, Chang, Howard Y, van de Vijver, Marc J

“…Abstract Introduction Gene expression profiling has been extensively used to predict outcome in breast cancer patients. We have previously reported on…”
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Impact of supervised gene signatures of early hypoxia on patient survival by Seigneuric, Renaud, Starmans, Maud H.W, Fung, Glenn, Krishnapuram, Balaji, Nuyten, Dimitry S.A, van Erk, Arie, Magagnin, Michael G, Rouschop, Kasper M, Krishnan, Sriram, Rao, R. Bharat, Evelo, Chris T.A, Begg, Adrian C, Wouters, Bradly G, Lambin, Philippe

“…Abstract Background and purpose Hypoxia is a common feature of solid tumors associated with therapy resistance, increased malignancy and poor prognosis…”
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Using Microarray Analysis as a Prognostic and Predictive Tool in Oncology: Focus on Breast Cancer and Normal Tissue Toxicity by Nuyten, Dimitry S.A., MD, van de Vijver, Marc J., MD, PhD

“…Microarray analysis makes it possible to study the expression levels of tens of thousands of genes in one single experiment and is widely available for…”
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The chemokine receptor CXCR6 and its ligand CXCL16 are expressed in carcinomas and inhibit proliferation by Meijer, Joost, Ogink, Janneke, Kreike, Bas, Nuyten, Dimitry, de Visser, Karin E, Roos, Ed

“…The chemokine receptor CXCR6 and its ligand CXCL16 are involved in inflammation. Thus far, they were known to be expressed mainly by T cells and macrophages,…”
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