Search Results - "Nuttall, Patricia"

Tick saliva and its role in pathogen transmission by Nuttall, Patricia A.

“…Summary Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding…”
Get full text

Climate change impacts on ticks and tick-borne infections by Nuttall, Patricia A.

“…Evidence climate change is impacting ticks and tick-borne infections is generally lacking. This is primarily because, in most parts of the world, there are no…”
Get full text

Wonders of tick saliva by Nuttall, Patricia A.

“…Saliva of ticks is arguably the most complex saliva of any animal. This is particularly the case for ixodid species that feed for many days firmly attached to…”
Get full text

The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus: A review of published field and laboratory studies by Gargili, Aysen, Estrada-Peña, Agustin, Spengler, Jessica R., Lukashev, Alexander, Nuttall, Patricia A., Bente, Dennis A.

“…This manuscript is part of a series of reviews that aim to cover published research on Crimean-Congo hemorrhagic fever (CCHF) and its etiological agent, CCHF…”
Get full text

Tick-Borne Viruses and Biological Processes at the Tick-Host-Virus Interface by Kazimírová, Mária, Thangamani, Saravanan, Bartíková, Pavlína, Hermance, Meghan, Holíková, Viera, Štibrániová, Iveta, Nuttall, Patricia A

“…Ticks are efficient vectors of arboviruses, although less than 10% of tick species are known to be virus vectors. Most tick-borne viruses (TBV) are RNA viruses…”
Get full text

The global distribution of Crimean-Congo hemorrhagic fever by Messina, Jane P., Pigott, David M., Golding, Nick, Duda, Kirsten A., Brownstein, John S., Weiss, Daniel J., Gibson, Harry, Robinson, Timothy P., Gilbert, Marius, William Wint, G. R., Nuttall, Patricia A., Gething, Peter W., Myers, Monica F., George, Dylan B., Hay, Simon I.

“…Background Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne infection caused by a virus (CCHFV) from the Bunyaviridae family. Domestic and wild…”
Get full text

Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses by Preston, Stephen G, Majtán, Juraj, Kouremenou, Chrisoula, Rysnik, Oliwia, Burger, Lena F, Cabezas Cruz, Alejandro, Chiong Guzman, Maylin, Nunn, Miles A, Paesen, Guido C, Nuttall, Patricia A, Austyn, Jonathan M

“…Hard ticks subvert the immune responses of their vertebrate hosts in order to feed for much longer periods than other blood-feeding ectoparasites; this may be…”
Get full text

Increased Relative Risk of Tick-Borne Encephalitis in Warmer Weather by Daniel, Milan, Danielová, Vlasta, Fialová, Alena, Malý, Marek, Kříž, Bohumír, Nuttall, Patricia A

“…Tick-borne encephalitis (TBE) is a serious acute neuroinfection of humans caused by a tick-borne flavivirus. The disease is typically seasonal, linked to the…”
Get full text

Editorial: Tick Saliva: Secret to Blood Feeding Success by Sonenshine, Daniel E, Nuttall, Patricia A, Narasimhan, Sukanya

Get full text

Abiotic predictors and annual seasonal dynamics of Ixodes ricinus, the major disease vector of Central Europe by Daniel, Milan, Malý, Marek, Danielová, Vlasta, Kříž, Bohumír, Nuttall, Patricia

“…Abiotic conditions provide cues that drive tick questing activity. Defining these cues is critical in predicting biting risk, and in forecasting climate change…”
Get full text

An antivector vaccine protects against a lethal vector-borne pathogen by Labuda, Milan, Trimnell, Adama R, Licková, Martina, Kazimírová, Mária, Davies, Gillian M, Lissina, Olga, Hails, Rosie S, Nuttall, Patricia A

“…Vaccines that target blood-feeding disease vectors, such as mosquitoes and ticks, have the potential to protect against the many diseases caused by…”
Get full text

Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors by Koh, Cho Yeow, Kumar, Sundramurthy, Kazimirova, Maria, Nuttall, Patricia A, Radhakrishnan, Uvaraj P, Kim, Seongcheol, Jagadeeswaran, Pudur, Imamura, Takayuki, Mizuguchi, Jun, Iwanaga, Sadaaki, Swaminathan, Kunchithapadam, Kini, R Manjunatha

“…The inhibition of thrombin is one of the important treatments of pathological blood clot formation. Variegin, isolated from the tropical bont tick, is a novel…”
Get full text

Prevalence of Borrelia burgdorferi and Borrelia miyamotoi in questing Ixodes ricinus ticks from four sites in the UK by Layzell, Scott J, Bailey, Daniel, Peacey, Mick, Nuttall, Patricia A

“…Borrelia miyamotoi is a spirochete bacterium related to Borrelia burgdorferi sensu lato, the cause of Lyme borreliosis, and vectored by ticks. In 2014, B…”
Get full text

Phylogenetic Analysis Indicates That Evasin-Like Proteins of Ixodid Ticks Fall Into Three Distinct Classes by Bhattacharya, Shoumo, Nuttall, Patricia Anne

“…Chemokines are structurally related proteins that activate leucocyte migration in response to injury or infection. Tick saliva contains chemokine-binding…”
Get full text

Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks by Roversi, Pietro, Johnson, Steven, Preston, Stephen G., Nunn, Miles A., Paesen, Guido C., Austyn, Jonathan M., Nuttall, Patricia A., Lea, Susan M.

“…Two crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick ( Rhipicephalus appendiculatus ), have been determined at 2.2…”
Get full text

Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection by Valdés, James J., Cabezas-Cruz, Alejandro, Sima, Radek, Butterill, Philip T., Růžek, Daniel, Nuttall, Patricia A.

“…Evolution has provided ticks with an arsenal of bioactive saliva molecules that counteract host defense mechanisms. This salivary pharmacopoeia enables…”
Get full text

Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum by Iyer, Janaki Krishnamoorthy, Koh, Cho Yeow, Kazimirova, Maria, Roller, Ladislav, Jobichen, Chacko, Swaminathan, Kunchithapadam, Mizuguchi, Jun, Iwanaga, Sadaaki, Nuttall, Patricia A., Chan, Mark Y., Kini, R. Manjunatha

“…ABSTRACT Tick saliva is a rich source of antihemostatic compounds. We amplified a cDNA from the salivary glands of the tropical bont tick (Amblyomma…”
Get full text

Complement Inhibitor of C5 Activation from the Soft Tick Ornithodoros moubata by Nunn, Miles A, Sharma, Ankit, Paesen, Guido C, Adamson, Sharon, Lissina, Olga, Willis, Anthony C, Nuttall, Patricia A

“…Blood-feeding ticks must control C activation or be damaged by the host inflammatory response. We report the characterization and expression of a novel,…”
Get full text

Ticks: Biology, Disease and Control by Bowman, Alan S, Nuttall, Patricia A

“…Widespread and increasing resistance to most available acaracides threatens both global livestock industries and public health. This necessitates better…”
Get full text

Variegin, a Novel Fast and Tight Binding Thrombin Inhibitor from the Tropical Bont Tick by Koh, Cho Yeow, Kazimirova, Maria, Trimnell, Adama, Takac, Peter, Labuda, Milan, Nuttall, Patricia A., Kini, R. Manjunatha

“…Tick saliva contains potent antihemostatic molecules that help ticks obtain their enormous blood meal during prolonged feeding. We isolated thrombin inhibitors…”
Get full text