Search Results - "Nuttall, Alfred L."

Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study by Wang, Ruikang K, Nuttall, Alfred L

“…Hearing loss can mean severe impairment to the quality of life. However, the biomechanical mechanisms of how the hearing organ, i.e., the organ of Corti (OC),…”
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The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea by He, Wenxuan, Burwood, George, Porsov, Edward V., Fridberger, Anders, Nuttall, Alfred L., Ren, Tianying

“…The prevailing theory of cochlear function states that outer hair cells amplify sound-induced vibration to improve hearing sensitivity and frequency…”
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Outer Hair Cell Somatic Electromotility In Vivo and Power Transfer to the Organ of Corti by Ramamoorthy, Sripriya, Nuttall, Alfred L.

“…The active amplification of sound-induced vibrations in the cochlea, known to be crucial for auditory sensitivity and frequency selectivity, is not well…”
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JAK2/STAT3 inhibition attenuates noise-induced hearing loss by Wilson, Teresa, Omelchenko, Irina, Foster, Sarah, Zhang, Yuan, Shi, Xiaorui, Nuttall, Alfred L

“…Signal transducers and activators of transcription 3 (STAT3) is a stress responsive transcription factor that plays a key role in oxidative stress-mediated…”
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Minimal basilar membrane motion in low-frequency hearing by Warren, Rebecca L., Ramamoorthy, Sripriya, Ciganović, Nikola, Zhang, Yuan, Wilson, Teresa M., Petrie, Tracy, Wang, Ruikang K., Jacques, Steven L., Reichenbach, Tobias, Nuttall, Alfred L., Fridberger, Anders

“…Low-frequency hearing is critically important for speech and music perception, but no mechanical measurements have previously been available from inner ears…”
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A differentially amplified motion in the ear for near-threshold sound detection by Nuttall, Alfred L, Chen, Fangyi, Zha, Dingjun, Fridberger, Anders, Zheng, Jiefu, Choudhury, Niloy, Jacques, Steven L, Wang, Ruikang K, Shi, Xiaorui

“…The mammalian cochlea can detect near-threshold sound signals by mechanically amplifying sub-nanometer vibrations of the basilar membrane. This study describes…”
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A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ by Nuttall, Alfred L., Ricci, Anthony J., Burwood, George, Harte, James M., Stenfelt, Stefan, Cayé-Thomasen, Per, Ren, Tianying, Ramamoorthy, Sripriya, Zhang, Yuan, Wilson, Teresa, Lunner, Thomas, Moore, Brian C. J., Fridberger, Anders

“…To understand speech, the slowly varying outline, or envelope, of the acoustic stimulus is used to distinguish words. A small amount of information about the…”
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ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points by Krey, Jocelyn F, Liu, Chang, Belyantseva, Inna A, Bateschell, Michael, Dumont, Rachel A, Goldsmith, Jennifer, Chatterjee, Paroma, Morrill, Rachel S, Fedorov, Lev M, Foster, Sarah, Kim, Jinkyung, Nuttall, Alfred L, Jones, Sherri M, Choi, Dongseok, Friedman, Thomas B, Ricci, Anthony J, Zhao, Bo, Barr-Gillespie, Peter G

“…The stereocilia rootlet is a key structure in vertebrate hair cells, anchoring stereocilia firmly into the cell's cuticular plate and protecting them from…”
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The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice by Burwood, George W. S., Dziennis, Suzan, Wilson, Teresa, Foster, Sarah, Zhang, Yuan, Liu, Gangjun, Yang, Jianlong, Elkins, Sean, Nuttall, Alfred L.

“…The mammalian cochlea possesses unique acoustic sensitivity due to a mechanoelectrical ‘amplifier’, which requires the metabolic support of the cochlear…”
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In vivo outer hair cell length changes expose the active process in the cochlea by Zha, Dingjun, Chen, Fangyi, Ramamoorthy, Sripriya, Fridberger, Anders, Choudhury, Niloy, Jacques, Steven L, Wang, Ruikang K, Nuttall, Alfred L

“…Mammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces…”
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The group delay and suppression pattern of the cochlear microphonic potential recorded at the round window by He, Wenxuan, Porsov, Edward, Kemp, David, Nuttall, Alfred L, Ren, Tianying

“…It is commonly assumed that the cochlear microphonic potential (CM) recorded from the round window (RW) is generated at the cochlear base. Based on this…”
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Half-octave shift in mammalian hearing is an epiphenomenon of the cochlear amplifier by Ramamoorthy, Sripriya, Nuttall, Alfred L

“…The cochlear amplifier is a hypothesized positive feedback process responsible for our exquisite hearing sensitivity. Experimental evidence for or against the…”
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Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography by Ramamoorthy, Sripriya, Zhang, Yuan, Petrie, Tracy, Fridberger, Anders, Ren, Tianying, Wang, Ruikang, Jacques, Steven L, Nuttall, Alfred L

“…Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100…”
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Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity by Yang, Yue, Dai, Min, Wilson, Teresa M, Omelchenko, Irina, Klimek, John E, Wilmarth, Phillip A, David, Larry L, Nuttall, Alfred L, Gillespie, Peter G, Shi, Xiaorui

“…The endothelial-blood/tissue barrier is critical for maintaining tissue homeostasis. The ear harbors a unique endothelial-blood/tissue barrier which we term…”
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Non-uniform Distribution of Outer Hair Cell Transmembrane Potential Induced by Extracellular Electric Field by Ramamoorthy, Sripriya, Wilson, Teresa M., Wu, Tao, Nuttall, Alfred L.

“…Intracochlear electric fields arising out of sound-induced receptor currents, silent currents, or electrical current injected into the cochlea induce…”
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Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system by Reif, Roberto, Qin, Jia, Shi, Lei, Dziennis, Suzan, Zhi, Zhongwei, Nuttall, Alfred L, Wang, Ruikang K

“…A synchronized dual-wavelength laser speckle contrast imaging (DWLSCI) system and a Doppler optical microangiography (DOMAG) system was developed to determine…”
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Optogenetic Control of Mouse Outer Hair Cells by Wu, Tao, Ramamoorthy, Sripriya, Wilson, Teresa, Chen, Fangyi, Porsov, Edward, Subhash, Hrebesh, Foster, Sarah, Zhang, Yuan, Omelchenko, Irina, Bateschell, Michael, Wang, Lingyan, Brigande, John V., Jiang, Zhi-Gen, Mao, Tianyi, Nuttall, Alfred L.

“…Normal hearing in mammals depends on sound amplification by outer hair cells (OHCs) presumably by their somatic motility and force production. However, the…”
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Instrumentation for studies of cochlear mechanics: From von Békésy forward by Nuttall, Alfred L., Fridberger, Anders

“…Georg von Békésy designed the instruments needed for his research. He also created physical models of the cochlea allowing him to manipulate the parameters…”
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The Biophysical Origin of Traveling-Wave Dispersion in the Cochlea by Ramamoorthy, Sripriya, Zha, Ding-Jun, Nuttall, Alfred L.

“…Sound processing begins at the peripheral auditory system, where it undergoes a highly complex transformation and spatial separation of the frequency…”
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Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles by Yang, Yuqin, Chen, Fangyi, Karasawa, Takatoshi, Ma, Ke-Tao, Guan, Bing-Cai, Shi, Xiao-Rui, Li, Hongzhe, Steyger, Peter S, Nuttall, Alfred L, Jiang, Zhi-Gen

“…The resting membrane potential (RP) of vascular smooth muscle cells (VSMCs) is a major determinant of cytosolic calcium concentration and vascular tone. The…”
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