Search Results - "Nutt, Stephen L."

Transcriptional Networks Driving Dendritic Cell Differentiation and Function by Nutt, Stephen L., Chopin, Michaël

“…Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of pathogens to stimulate a robust and appropriate immune response. To…”
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Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation by Matsumoto, Masanori, Baba, Akemi, Yokota, Takafumi, Nishikawa, Hiroyoshi, Ohkawa, Yasuyuki, Kayama, Hisako, Kallies, Axel, Nutt, Stephen L., Sakaguchi, Shimon, Takeda, Kiyoshi, Kurosaki, Tomohiro, Baba, Yoshihiro

“…B cells can suppress autoimmunity by secreting interleukin-10 (IL-10). Although subpopulations of splenic B lineage cells are reported to express IL-10…”
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Plasma cells: The programming of an antibody‐secreting machine by Tellier, Julie, Nutt, Stephen L

“…Antibodies are an essential component of our immune system, underpinning the effectiveness of both the primary immune response to microbial pathogens and the…”
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The generation of antibody-secreting plasma cells by Nutt, Stephen L., Hodgkin, Philip D., Tarlinton, David M., Corcoran, Lynn M.

“…Key Points The terminal differentiation of B cells generates short-lived plasmablasts and long-lived plasma cells, both of which secrete antibodies. B cells…”
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Transcriptional programming of the dendritic cell network by Belz, Gabrielle T., Nutt, Stephen L.

“…Key Points Dendritic cells (DCs) can be divided into multiple specialized subsets that are pivotal in bridging between the innate and adaptive immune…”
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Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response by Tellier, Julie, Shi, Wei, Minnich, Martina, Liao, Yang, Crawford, Simon, Smyth, Gordon K, Kallies, Axel, Busslinger, Meinrad, Nutt, Stephen L

“…The transcription factor Blimp-1 is required for the differentiation of activated B cells into plasmablasts. Nutt and colleagues show that plasma cells need…”
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Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation by Minnich, Martina, Tagoh, Hiromi, Bönelt, Peter, Axelsson, Elin, Fischer, Maria, Cebolla, Beatriz, Tarakhovsky, Alexander, Nutt, Stephen L, Jaritz, Markus, Busslinger, Meinrad

“…Blimp-1 is known to act as a transcriptional repressor by suppressing genes associated with mature and activated germinal center B cells. Busslinger and…”
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The cis-Regulatory Atlas of the Mouse Immune System by Yoshida, Hideyuki, Lareau, Caleb A., Ramirez, Ricardo N., Rose, Samuel A., Maier, Barbara, Wroblewska, Aleksandra, Desland, Fiona, Chudnovskiy, Aleksey, Mortha, Arthur, Dominguez, Claudia, Tellier, Julie, Kim, Edy, Dwyer, Dan, Shinton, Susan, Nabekura, Tsukasa, Qi, YiLin, Yu, Bingfei, Robinette, Michelle, Kim, Ki-Wook, Wagers, Amy, Rhoads, Andrew, Nutt, Stephen L., Brown, Brian D., Mostafavi, Sara, Buenrostro, Jason D., Benoist, Christophe

“…A complete chart of cis-regulatory elements and their dynamic activity is necessary to understand the transcriptional basis of differentiation and function of…”
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Innate lymphoid cells: More than just immune cells by Xiong, Le, Nutt, Stephen L., Seillet, Cyril

“…Since their discovery, innate lymphoid cells (ILCs) have been described as the innate counterpart of the T cells. Indeed, ILCs and T cells share many features…”
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Positive Feedback Between PU.1 and the Cell Cycle Controls Myeloid Differentiation by Kueh, Hao Yuan, Champhekhar, Ameya, Nutt, Stephen L., Elowitz, Michael B., Rothenberg, Ellen V.

“…Regulatory gene circuits with positive-feedback loops control stem cell differentiation, but several mechanisms can contribute to positive feedback. Here, we…”
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Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells by Shi, Wei, Liao, Yang, Willis, Simon N, Taubenheim, Nadine, Inouye, Michael, Tarlinton, David M, Smyth, Gordon K, Hodgkin, Philip D, Nutt, Stephen L, Corcoran, Lynn M

“…The process of B cell differentiation into plasma cells involves dramatic cellular reprogramming. Corcoran and colleagues profile the transcriptome of all…”
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M-CSF instructs myeloid lineage fate in single haematopoietic stem cells by Mossadegh-Keller, Noushine, Sarrazin, Sandrine, Kandalla, Prashanth K., Espinosa, Leon, Stanley, E. Richard, Nutt, Stephen L., Moore, Jordan, Sieweke, Michael H.

“…M-CSF, a myeloid cytokine released during infection and inflammation, instructs myeloid lineage fate in single haematopoietic stem cells by directly inducing…”
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The Transcriptional Regulation of B Cell Lineage Commitment by Nutt, Stephen L., Kee, Barbara L.

“…The expression of lineage-associated genes, as well as the survival and expansion of committed B cell progenitors, is controlled by multiple transcriptional…”
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New players in the gene regulatory network controlling late B cell differentiation by Willis, Simon N, Nutt, Stephen L

“…•Multiple intrinsic and extrinsic inputs control B cell terminal differentiation.•Differentiation is associated with loss of CpG methylation at…”
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Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function by Andreani, Virginia, Ramamoorthy, Senthilkumar, Pandey, Abhinav, Lupar, Ekaterina, Nutt, Stephen L., Lämmermann, Tim, Grosschedl, Rudolf

“…Plasma cell differentiation involves coordinated changes in gene expression and functional properties of B cells. Here, we study the role of Mzb1, a Grp94…”
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Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma by Jacquelot, Nicolas, Seillet, Cyril, Wang, Minyu, Pizzolla, Angela, Liao, Yang, Hediyeh-zadeh, Soroor, Grisaru-Tal, Sharon, Louis, Cynthia, Huang, Qiutong, Schreuder, Jaring, Souza-Fonseca-Guimaraes, Fernando, de Graaf, Carolyn A., Thia, Kevin, Macdonald, Sean, Camilleri, Mary, Luong, Kylie, Zhang, Shengbo, Chopin, Michael, Molden-Hauer, Tristan, Nutt, Stephen L., Umansky, Viktor, Ciric, Bogoljub, Groom, Joanna R., Foster, Paul S., Hansbro, Philip M., McKenzie, Andrew N. J., Gray, Daniel H. D., Behren, Andreas, Cebon, Jonathan, Vivier, Eric, Wicks, Ian P., Trapani, Joseph A., Munitz, Ariel, Davis, Melissa J., Shi, Wei, Neeson, Paul J., Belz, Gabrielle T.

“…Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic…”
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Mcl-1 is essential for the survival of plasma cells by Peperzak, Victor, Vikström, Ingela, Walker, Jennifer, Glaser, Stefan P, LePage, Melanie, Coquery, Christine M, Erickson, Loren D, Fairfax, Kirsten, Mackay, Fabienne, Strasser, Andreas, Nutt, Stephen L, Tarlinton, David M

“…Tarlinton and colleagues show that the antiapoptotic protein Mcl1 is essential for plasma cell survival and is induced by BCMA signaling in bone marrow, but…”
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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism by Zotos, Dimitra, Coquet, Jonathan M, Zhang, Yang, Light, Amanda, D'Costa, Kathy, Kallies, Axel, Corcoran, Lynn M, Godfrey, Dale I, Toellner, Kai-Michael, Smyth, Mark J, Nutt, Stephen L, Tarlinton, David M

“…Germinal centers (GCs) are sites of B cell proliferation, somatic hypermutation, and selection of variants with improved affinity for antigen. Long-lived…”
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Transcription-factor-mediated supervision of global genome architecture maintains B cell identity by Johanson, Timothy M., Lun, Aaron T. L., Coughlan, Hannah D., Tan, Tania, Smyth, Gordon K., Nutt, Stephen L., Allan, Rhys S.

“…Recent studies have elucidated cell-lineage-specific three-dimensional genome organization; however, how such specific architecture is established or…”
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Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB by Willis, Simon N., Tellier, Julie, Liao, Yang, Trezise, Stephanie, Light, Amanda, O’Donnell, Kristy, Garrett-Sinha, Lee Ann, Shi, Wei, Tarlinton, David M., Nutt, Stephen L.

“…Humoral immunity requires B cells to respond to multiple stimuli, including antigen, membrane and soluble ligands, and microbial products. Ets family…”
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