Search Results - "Nutt, R F"

Analysis of Large Screening Data Sets via Adaptively Grown Phylogenetic-Like Trees by Nicolaou, C. A, Tamura, S. Y, Kelley, B. P, Bassett, S. I, Nutt, R. F

“…As the use of high-throughput screening systems becomes more routine in the drug discovery process, there is an increasing need for fast and reliable analysis…”
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Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors:  P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties by Semple, J. Edward, Rowley, David C, Brunck, Terence K, Ha-Uong, Theresa, Minami, Nathaniel K, Owens, Timothy D, Tamura, Susan Y, Goldman, Erick A, Siev, Daniel V, Ardecky, Robert J, Carpenter, Stephen H, Ge, Yu, Richard, Brigitte M, Nolan, Thomas G, Håkanson, Kjell, Tulinsky, Al, Nutt, Ruth F, Ripka, William C

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Specific Membrane Receptors for Atrial Natriuretic Factor in Renal and Vascular Tissues by Napier, M. A., Vandlen, R. L., Albers-Schönberg, G., Nutt, R. F., Brady, S., Lyle, T., Winquist, R., Faison, E. P., Heinel, L. A., Blaine, E. H.

“…Membranes from rabbit aorta and from rabbit and rat kidney cortex possess high-affinity (Kd = 10-10 M) specific binding sites for atrial natriuretic factor…”
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An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey by COOK, J. J, SITKO, G. R, BEDNAR, B, CONDRA, C, MELLOTT, M. J, DONG-MEI FENG, NUTT, R. F, SHAFER, J. A, GOULD, R. J, CONNOLLY, T. M

“…Thrombin inhibitors have been shown to be efficacious in animal models of thrombosis and in initial human clinical trials. It is unknown if their efficacy is…”
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Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides by Connolly, T M, Condra, C, Feng, D M, Cook, J J, Stranieri, M T, Reilly, C F, Nutt, R F, Gould, R J

“…The aggregation of platelets from a variety of animal species in response to thrombin receptor-derived activating peptides was evaluated. A series of…”
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Potent and Selective Thrombin Inhibitors Incorporating the Constrained Arginine Mimic l-3-Piperidyl(N-guanidino)alanine at P1 by Levy, Odile E, Semple, J. Edward, Lim, Michael L, Reiner, John, Rote, William E, Dempsey, Erin, Richard, Brigitte M, Zhang, Erli, Tulinsky, Al, Ripka, William C, Nutt, Ruth F

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Amino Acid Sequence of Homologous Rat Atrial Peptides: Natriuretic Activity of Native and Synthetic Forms by Seidah, N. G., Lazure, C., Chrétien, M., Thibault, G., Garcia, R., Cantin, M., Genest, J., Nutt, R. F., Brady, S. F., Lyle, T. A., Paleveda, W. J., Colton, C. D., Ciccarone, T. M., Veber, D. F.

“…A substance called atrial natriuretic factor (ANF), localized in secretory granules of atrial cardiocytes, was isolated as four homologous natriuretic peptides…”
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Development of a Potent Thrombin Receptor Ligand by Feng, Dong-Mei, Veber, Daniel F, Connolly, Thomas M, Condra, Cindra, Tang, Mei-Jy, Nutt, Ruth F

“…The N-terminal thrombin receptor peptide H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH (1) fully activates the thrombin receptor with an EC50 of…”
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HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins by Darke, P L, Nutt, R F, Brady, S F, Garsky, V M, Ciccarone, T M, Leu, C T, Lumma, P K, Freidinger, R M, Veber, D F, Sigal, I S

“…The mature proteins of retroviruses originate as a result of proteolytic cleavages of polyprotein precursors. Retroviruses encode proteases responsible for…”
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Similarity of Synthetic Peptide from Human Tumor to Parathyroid Hormone in vivo and in vitro by Horiuchi, Noboru, Caulfield, Michael P., Fisher, John E., Goldman, Mark E., McKee, Roberta L., Reagan, Jane E., Levy, Jay J., Nutt, Ruth F., Rodan, Sevgi B., Schofield, Timothy L., Clemens, Thomas L., Rosenblatt, Michael

“…One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters…”
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Chemical Synthesis and Enzymatic Activity of a 99-Residue Peptide with a Sequence Proposed for the Human Immunodeficiency Virus Protease by Nutt, Ruth F., Brady, Stephen F., Darke, Paul L., Ciccarone, Terrence M., Colton, C. Dylion, Nutt, Elka M., Rodkey, John A., Bennett, Carl D., Waxman, Lloyd H., Sigal, Irving S., Anderson, Paul S., Veber, Daniel F.

“…Retroviral proteins, including those from the human immunodeficiency virus (HIV), are synthesized as polyprotein precursors that require proteolytic cleavage…”
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Disposable bedpads for incontinence: predicting their clinical leakage properties using laboratory tests by Cottenden, A.M, Dean, G.E, Brooks, R.J, Haines-Nutt, R.F, Rothwell, J.G, Penfold, P.H

“…A multi-centre project has been run to identify laboratory tests capable of predicting the leakage performance of disposable incontinence bedpads. Each of 95…”
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Guanylpiperidine peptidomimetics : Potent and selective bis-cation inhibitors of factor Xa by TAMURA, S. Y, LEVY, O. E, SEMPLE, J. E, UONG, T. H, REINER, J. E, GOLDMAN, E. A, HO, J. Z, COHEN, C. R, BERGUM, P. W, NUTT, R. F, BRUNCK, T. K

“…A novel series of rigid P3-guanylpiperidine peptide mimics 3-14 was designed as potential factor Xa and prothrombinase inhibitors. Incorporation into a…”
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Primary structure of peptides and ion channels. Role of amino acid side chains in voltage gating of melittin channels by Tosteson, M.T., Alvarez, O., Hubbell, W., Bieganski, R.M., Attenbach, C., Caporales, L.H., Levy, J.J., Nutt, R.F., Rosenblatt, M., Tosteson, D.C.

“…Melittin produces a voltage-dependent increase in the conductance of planar lipid bilayers. The conductance increases when the side of the membrane to which…”
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Identification of high affinity endothelin-1 receptor subtypes in human tissues by Williams, Jr, D L, Jones, K L, Colton, C D, Nutt, R F

“…Two subtypes of the high affinity endothelin-1 (ET-1) receptor were identified in human tissue, and were distinguished by their differential affinities for…”
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Evaluation of novel parathyroid hormone analogs using a bovine renal membrane receptor binding assay by Goldman, M E, Chorev, M, Reagan, J E, Nutt, R F, Levy, J J, Rosenblatt, M

“…A PTH membrane receptor binding assay based on a stable hormone analog radioligand was refined and used with bovine renal cortical membranes to evaluate PTH…”
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Vasodilator profile of synthetic atrial natriuretic factor by Winquist, R J, Faison, E P, Nutt, R F

“…The vasodilator profile of synthetic atrial natriuretic factor (ANF) was characterized using isolated vascular preparations. Nanomolar concentrations of ANF…”
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Quantitation of an orally available thrombin inhibitor in rat, monkey and human plasma and in human urine by high-performance liquid chromatography and fluorescent post-column derivatization of arginine by Mendoza, C.B., Dixon, S.A., Lods, M.M., Ma, M.G., Nguyen, K.T., Nutt, R.F., Tran, H.S., Nolan, T.G.

“…An assay for the quantification of plasma and urine levels of CVS 1123, an orally bioavailable thrombin inhibitor, and its desmethyl form, CVS 738, was…”
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Inhibition of thrombin by peptides containing Lysyl-alpha-keto carbonyl derivatives by Lewis, S D, Ng, A S, Lyle, E A, Mellott, M J, Appleby, S D, Brady, S F, Stauffer, K J, Sisko, J T, Mao, S S, Veber, D F

“…Several H-N-Me-D-Phe-Pro-Lysyl-alpha-keto carbonyl derivatives were shown to be potent thrombin inhibitors (Ki 0.2 to 27 nM). The inhibitory potencies of these…”
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Renal and systemic effects of synthetic atrial natriuretic factor by Seymour, A A, Blaine, E H, Mazack, E K, Smith, S G, Stabilito, I I, Haley, A B, Napier, M A, Whinnery, M A, Nutt, R F

“…A synthetic peptide corresponding to a sequence of 26 amino acids contained in endogenous rat atrial natriuretic factor (ANF), was infused into one renal…”
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