Search Results - "Nutiu, Razvan"

Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing by Mustoe, Anthony M., Busan, Steven, Rice, Greggory M., Hajdin, Christine E., Peterson, Brant K., Ruda, Vera M., Kubica, Neil, Nutiu, Razvan, Baryza, Jeremy L., Weeks, Kevin M.

“…mRNAs can fold into complex structures that regulate gene expression. Resolving such structures de novo has remained challenging and has limited our…”
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In Vitro Selection of Structure-Switching Signaling Aptamers by Nutiu, Razvan, Li, Yingfu

“…Picking out probes: A novel approach permits isolation of standard DNA aptamers by in vitro selection and conversion into fluorescence signaling probes. This…”
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Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument by Burge, Christopher B, Nutiu, Razvan, Friedman, Robin C, Luo, Shujun, Khrebtukova, Irina, Silva, David, Li, Robin, Zhang, Lu, Schroth, Gary P

“…Several methods for characterizing DNA-protein interactions are available, but none have demonstrated both high throughput and quantitative measurement of…”
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Solid-Phase Enzyme Activity Assay Utilizing an Entrapped Fluorescence-Signaling DNA Aptamer by Rupcich, Nicholas, Nutiu, Razvan, Li, Yingfu, Brennan, John D.

“…Layered enzyme assays: The use of a layered sol‐gel based material allows for spatial separation of coimmobilized enzyme and fluorescent aptamer reporter…”
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Affinity Analysis of a Protein−Aptamer Complex Using Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures by Berezovski, Maxim, Nutiu, Razvan, Li, Yingfu, Krylov, Sergey N

“…We propose a new method that allows the use of low-affinity aptamers as affinity probes in quantitative analyses of proteins. The method is based on…”
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Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign by Smith, Thomas M, Lim, Siew Pheng, Yue, Kimberley, Busby, Scott A, Arora, Rishi, Seh, Cheah Chen, Wright, S Kirk, Nutiu, Razvan, Niyomrattanakit, Pornwaratt, Wan, Kah Fei, Beer, David, Shi, Pei-Yong, Benson, Timothy E

“…Dengue virus (DENV) is the most significant mosquito-borne viral pathogen in the world and is the cause of dengue fever. The DENV RNA-dependent RNA polymerase…”
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Quenching of Fluorophore-Labeled DNA Oligonucleotides by Divalent Metal Ions:  Implications for Selection, Design, and Applications of Signaling Aptamers and Signaling Deoxyribozymes by Rupcich, Nicholas, Chiuman, William, Nutiu, Razvan, Mei, Shirley, Flora, Kulwinder K, Li, Yingfu, Brennan, John D

“…Recent years have seen a dramatic increase in the use of fluorescence-signaling DNA aptamers and deoxyribozymes as novel biosensing moieties. Many of these…”
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Kinetics of signaling-DNA-aptamer-ATP binding by Nakamura, Issei, Shi, An-Chang, Nutiu, Razvan, Yu, Jasmine M Y, Li, Yingfu

“…DNA aptamers are molecular biosensors consisting of single functionalized DNA molecules, which can bind to specific targets or complementary DNA sequences. The…”
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A DNA-Protein Nanoengine for "On-Demand" Release and Precise Delivery of Molecules by Nutiu, Razvan, Li, Yingfu

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Functional Atlas of Primary miRNA Maturation by the Microprocessor by Rice, Greggory M., Shivashankar, Varun, Ma, Eric J., Baryza, Jeremy L., Nutiu, Razvan

“…Primary microRNAs (miRNAs) are the precursors of miRNAs that modulate the expression of most mRNAs in humans. They fold up into a hairpin structure that is…”
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Structure-Switching Signaling Aptamers by Nutiu, Razvan, Li, Yingfu

“…Aptamers are single-stranded nucleic acids with defined tertiary structures for selective binding to target molecules. Aptamers are also able to bind a…”
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Structure-Switching Signaling Aptamers: Transducing Molecular Recognition into Fluorescence Signaling by Nutiu, Razvan, Li, Yingfu

“…The development of aptamer technology considerably broadens the utility of nucleic acids as molecular recognition elements, because it allows the creation of…”
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Aptamers with fluorescence-signaling properties by Nutiu, Razvan, Li, Yingfu

“…Aptamers are single-stranded DNA or RNA molecules with ligand-binding capabilities. Signaling aptamers refer to aptamers or modified aptamers with recordable…”
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Splice site strength-dependent activity and genetic buffering by poly-G runs by Wang, Zefeng, Xiao, Xinshu, Jang, Minyoung, Burge, Christopher B, Wang, Eric T, Nutiu, Razvan

“…Alternative splicing increases genome coding potential and is affected by factors including the hnRNPs. The effect of altering splice site strength on splicing…”
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Identifying mRNA sequence elements for target recognition by human Argonaute proteins by Li, Jingjing, Kim, TaeHyung, Nutiu, Razvan, Ray, Debashish, Hughes, Timothy R, Zhang, Zhaolei

“…It is commonly known that mammalian microRNAs (miRNAs) guide the RNA-induced silencing complex (RISC) to target mRNAs through the seed-pairing rule. However,…”
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A DNA–Protein Nanoengine for “On‐Demand” Release and Precise Delivery of Molecules by Nutiu, Razvan, Li, Yingfu

“…A DNA aptamer (green in the scheme), an antisense DNA strand (purple), and an enzyme (blue) form a nanoengine that responds to a small‐molecule input (red) and…”
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SnapShot: High-Throughput Sequencing Applications by Han, Hong, Nutiu, Razvan, Moffat, Jason, Blencowe, Benjamin J.

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Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions by Tuck, Alex C, Natarajan, Kedar Nath, Rice, Greggory M, Borawski, Jason, Mohn, Fabio, Rankova, Aneliya, Flemr, Matyas, Wenger, Alice, Nutiu, Razvan, Teichmann, Sarah, Bühler, Marc

“…Eukaryotic genomes produce RNAs lacking protein-coding potential, with enigmatic roles. We integrated three approaches to study large intervening noncoding RNA…”
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Adsorption and Covalent Coupling of ATP-Binding DNA Aptamers onto Cellulose by Su, Shunxing, Nutiu, Razvan, Filipe, Carlos D. M, Li, Yingfu, Pelton, Robert

“…With the long-term goal of developing paper surfaces that will detect pathogens, we have investigated physical adsorption and covalent coupling as strategies…”
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Tau protein binds single-stranded DNA sequence specifically – the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures by Krylova, Svetlana M., Musheev, Michael, Nutiu, Razvan, Li, Yingfu, Lee, Gloria, Krylov, Sergey N.

“…Tau is a microtubule-associated protein, which plays an important role in physiology and pathology of neurons. Tau has been recently reported to bind…”
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