Search Results - "Nussenzweig, Michel C."

Germinal Centers by Victora, Gabriel D, Nussenzweig, Michel C

“…Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody affinity maturation. Therein, B cells undergo the Darwinian process of…”
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Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic by Caskey, Marina, Klein, Florian, Nussenzweig, Michel C.

“…Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of HIV-1 infection. Taken daily, ART prevents and suppresses the…”
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Germinal Centers by Victora, Gabriel D, Nussenzweig, Michel C

“…Germinal centers (GCs) were described more than 125 years ago as compartments within secondary lymphoid organs that contained mitotic cells. Since then, it has…”
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Plasma Neutralization of the SARS-CoV-2 Omicron Variant by Schmidt, Fabian, Muecksch, Frauke, Weisblum, Yiska, Da Silva, Justin, Bednarski, Eva, Cho, Alice, Wang, Zijun, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over…”
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Origin and development of dendritic cells by Liu, Kang, Nussenzweig, Michel C

“…Dendritic cells (DCs) are specialized antigen-presenting cells and essential mediators of immunity and tolerance. This group of cells is heterogeneous in terms…”
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Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity by Bournazos, Stylianos, Klein, Florian, Pietzsch, John, Seaman, Michael S, Nussenzweig, Michel C, Ravetch, Jeffrey V

“…Broadly neutralizing antibodies (bNAbs) against HIV-1 provide both effective pre-exposure prophylaxis and treatment of HIV-1 infection in murine and nonhuman…”
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Origin of Chromosomal Translocations in Lymphoid Cancer by Nussenzweig, André, Nussenzweig, Michel C.

“…Aberrant fusions between heterologous chromosomes are among the most prevalent cytogenetic abnormalities found in cancer cells. Oncogenic chromosomal…”
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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization by Klein, Florian, Diskin, Ron, Scheid, Johannes F., Gaebler, Christian, Mouquet, Hugo, Georgiev, Ivelin S., Pancera, Marie, Zhou, Tongqing, Incesu, Reha-Baris, Fu, Brooks Zhongzheng, Gnanapragasam, Priyanthi N.P., Oliveira, Thiago Y., Seaman, Michael S., Kwong, Peter D., Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of great importance for HIV-1 vaccine design. Notably, bNAbs…”
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Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy by West, Anthony P., Scharf, Louise, Scheid, Johannes F., Klein, Florian, Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when…”
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SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

“…The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding…”
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Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses by Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Lorenzi, Julio C C, Mendoza, Pilar, Rutkowska, Magdalena, Bednarski, Eva, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Caskey, Marina, Robbiani, Davide F, Nussenzweig, Michel C, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D

“…The emergence of SARS-CoV-2 and the ensuing explosive epidemic of COVID-19 disease has generated a need for assays to rapidly and conveniently measure the…”
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Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity by Finkin, Shlomo, Hartweger, Harald, Oliveira, Thiago Y., Kara, Ervin E., Nussenzweig, Michel C.

“…High-affinity B cell selection in the germinal center (GC) is governed by signals delivered by follicular helper T (Tfh) cells to B cells. Selected B cells…”
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Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates by Viant, Charlotte, Weymar, Georg H.J., Escolano, Amelia, Chen, Spencer, Hartweger, Harald, Cipolla, Melissa, Gazumyan, Anna, Nussenzweig, Michel C.

“…Immunological memory is required for protection against repeated infections and is the basis of all effective vaccines. Antibodies produced by memory B cells…”
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High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape by Schmidt, Fabian, Weisblum, Yiska, Rutkowska, Magdalena, Poston, Daniel, DaSilva, Justin, Zhang, Fengwen, Bednarski, Eva, Cho, Alice, Schaefer-Babajew, Dennis J., Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Hatziioannou, Theodora, Bieniasz, Paul D.

“…The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in individuals who are SARS-CoV-2 convalescent and vaccinated are key…”
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Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection by Wang, Zijun, Muecksch, Frauke, Schaefer-Babajew, Dennis, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Hoffmann, Hans- Heinrich, Barnes, Christopher O., Cipolla, Melissa, Ramos, Victor, Oliveira, Thiago Y., Cho, Alice, Schmidt, Fabian, Da Silva, Justin, Bednarski, Eva, Aguado, Lauren, Yee, Jim, Daga, Mridushi, Turroja, Martina, Millard, Katrina G., Jankovic, Mila, Gazumyan, Anna, Zhao, Zhen, Rice, Charles M., Bieniasz, Paul D., Caskey, Marina, Hatziioannou, Theodora, Nussenzweig, Michel C.

“…More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Antibodies in HIV-1 Vaccine Development and Therapy by Klein, Florian, Mouquet, Hugo, Dosenovic, Pia, Scheid, Johannes F., Scharf, Louise, Nussenzweig, Michel C.

“…Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of…”
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Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice by Cohen, Alexander A, Gnanapragasam, Priyanthi N P, Lee, Yu E, Hoffman, Pauline R, Ou, Susan, Kakutani, Leesa M, Keeffe, Jennifer R, Wu, Hung-Jen, Howarth, Mark, West, Anthony P, Barnes, Christopher O, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-related emergent zoonotic coronaviruses is urgently needed. We made…”
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies by Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal…”
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Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes by Klein, Isaac A., Resch, Wolfgang, Jankovic, Mila, Oliveira, Thiago, Yamane, Arito, Nakahashi, Hirotaka, Di Virgilio, Michela, Bothmer, Anne, Nussenzweig, Andre, Robbiani, Davide F., Casellas, Rafael, Nussenzweig, Michel C.

“…Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of…”
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Early antibody therapy can induce long-lasting immunity to SHIV by Nishimura, Yoshiaki, Gautam, Rajeev, Chun, Tae-Wook, Sadjadpour, Reza, Foulds, Kathryn E., Shingai, Masashi, Klein, Florian, Gazumyan, Anna, Golijanin, Jovana, Donaldson, Mitzi, Donau, Olivia K., Plishka, Ronald J., Buckler-White, Alicia, Seaman, Michael S., Lifson, Jeffrey D., Koup, Richard A., Fauci, Anthony S., Nussenzweig, Michel C., Martin, Malcolm A.

“…Early administration of broadly neutralizing antibodies in a macaque SHIV infection model is associated with very low levels of persistent viraemia, which…”
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