Search Results - "Nussbaum, A K"

Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products by Toes, R E, Nussbaum, A K, Degermann, S, Schirle, M, Emmerich, N P, Kraft, M, Laplace, C, Zwinderman, A, Dick, T P, Müller, J, Schönfisch, B, Schmid, C, Fehling, H J, Stevanovic, S, Rammensee, H G, Schild, H

“…Proteasomes are the main proteases responsible for cytosolic protein degradation and the production of major histocompatibility complex class I ligands…”
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PAProC: a prediction algorithm for proteasomal cleavages available on the WWW by Nussbaum, A K, Kuttler, C, Hadeler, K P, Rammensee, H G, Schild, H

“…The first version of PAProC (Prediction Algorithm for Proteasomal Cleavages) is now available to the general public. PAProC is a prediction tool for cleavages…”
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Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants by Dick, Tobias P., Nussbaum, Alexander K., Deeg, Martin, Heinemeyer, Wolfgang, Groll, Michael, Schirle, Markus, Keilholz, Wieland, Stevanović, Stefan, Wolf, Dieter H., Huber, Robert, Rammensee, Hans-Georg, Schild, Hansjörg

“…Proteasomes generate peptides that can be presented by major histocompatibility complex (MHC) class I molecules in vertebrate cells. Using yeast 20 S…”
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Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1 by Nussbaum, A.K. (Universitat Tubingen, Tubingen, Germany.), Dick, T.P, Keilholz, W, Schirle, M, Stevanovic, S, Rammensee, H.G, Schild, H

“…The 436-amino acid protein enolase 1 from yeast was degraded in vitro by purified wild-type and mutant yeast 20S proteasome particles. Analysis of the cleavage…”
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An algorithm for the prediction of proteasomal cleavages by Kuttler, Christina, Nussbaum, Alexander K, Dick, Tobias P, Rammensee, Hans-Georg, Schild, Hansjörg, Hadeler, Karl-Peter

“…Proteasomes, major proteolytic sites in eukaryotic cells, play an important part in major histocompatibility class I (MHC I) ligand generation and thus in the…”
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The Human 26 S and 20 S Proteasomes Generate Overlapping but Different Sets of Peptide Fragments from a Model Protein Substrate by Emmerich, Niels P.N., Nussbaum, Alexander K., Stevanovic, Stefan, Priemer, Martin, Toes, René E.M., Rammensee, Hans-Georg, Schild, Hansjörg

“…Intracellular protein degradation is a major source of short antigenic peptides that can be presented on the cell surface in the context of major…”
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The regulation and maturation of antiviral immune responses by Whitton, J Lindsay, Slifka, Mark K, Liu, Fei, Nussbaum, Alexander K, Whitmire, Jason K

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Cleaving proteins for the immune system by Hadeler, K.P., Kuttler, Christina, Nussbaum, Alexander K.

“…Proteasomes are enzymes in eukaryotic cells which cut proteins marked for degradation into fragments. In mammals some of these fragments are used by the immune…”
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Using the World Wide Web for predicting CTL epitopes by Nussbaum, A K, Kuttler, C, Tenzer, S, Schild, H

“…The development of vaccines and also of methods for the monitoring of cytotoxic T lymphocyte (CTL) responses depends on the identification of epitopes from…”
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Prediction of proteasome cleavage motifs by neural networks by Keşmir, Can, Nussbaum, Alexander K., Schild, Hansjörg, Detours, Vincent, Brunak, Søren

“…We present a predictive method that can simulate an essential step in the antigen presentation in higher vertebrates, namely the step involving the proteasomal…”
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The function of the proteasome system in MHC class I antigen processing by Stoltze, Lars, Nussbaum, Alexander K., Sijts, Alice, Emmerich, Niels P.N., Kloetzel, Peter-M., Schild, Hansjörg

“…A recent meeting * * 1st Charité Zeuthener See Workshop on the function of the proteasome system in MHC class I antigen processing, 2–4 April 2000. brought…”
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Immunoproteasome-Deficient Mice Mount Largely Normal CD8+ T Cell Responses to Lymphocytic Choriomeningitis Virus Infection and DNA Vaccination by Nussbaum, Alexander K, Rodriguez-Carreno, Maria P, Benning, Nicola, Botten, Jason, Whitton, J. Lindsay

“…During viral infection, constitutive proteasomes are largely replaced by immunoproteasomes, which display distinct cleavage specificities, resulting in…”
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The Contraction Phase of Virus-Specific CD8+ T Cells Is Unaffected by a Pan-Caspase Inhibitor by Nussbaum, Alexander K, Whitton, J. Lindsay

“…The effectiveness of protection conferred by CD8(+) memory T cells is determined by both their quality and their quantity, which suggests that vaccine efficacy…”
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Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells by YUANSHENG SUN, SIJTS, Alice J. A. M, KLOETZEL, Peter-M, SCHADENDORF, Dirk, MINGXIA SONG, JANEK, Katharina, NUSSBAUM, Alexander K, KRAL, Sylvie, SCHIRLE, Markus, STEVANOVIC, Stefan, PASCHEN, Annette, SCHILD, Hansjörg

“…The proteasome system represents a major source of HLA class I- presented peptides exposed to CTLs. Stimulation of cells with IFN-gamma instantly induces the…”
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Using the World Wide Web for predicting CTL epitopes by Nussbaum, Alexander K, Kuttler, Christina, Tenzer, Stefan, Schild, Hansjörg

“…The development of vaccines and also of methods for the monitoring of cytotoxic T lymphocyte (CTL) responses depends on the identification of epitopes from…”
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A CTL epitope from human cytomegalovirus IE1 defined by combining prediction of HLA binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation by Hebart, Holger, Rauser, Georg, Stevanovic, Stefan, Haenle, Claire, Nussbaum, Alexander K, Meisner, Christoph, Bissinger, Alfred L, Tenzer, Stefan, Jahn, Gerhard, Loeffler, Juergen, Rammensee, Hans-Georg, Schild, Hansjörg, Einsele, Hermann

“…In an attempt to define HCMV IE1-derived, HLA-A ∗0201-restricted epitopes, an advanced computer-based epitope prediction combining HLA binding and proteasomal…”
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Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O by Bruder, Dunja, Nussbaum, Alexander K., Gakamsky, Dimitry M., Schirle, Markus, Stevanovic, Stefan, Singh-Jasuja, Harpreet, Darji, Ayub, Chakraborty, Trinad, Schild, Hansjörg, Pecht, Israel, Weiss, Siegfried

“…Immunodominance in CD8+ T cell responses against Listeria monocytogenes is a well-recognized but still not fully understood phenomenon. From listeriolysin, the…”
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