Search Results - "Nusrat, Asma"

Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation by Garcia‐Hernandez, Vicky, Quiros, Miguel, Nusrat, Asma

“…The intestinal epithelium forms a highly dynamic and selective barrier that controls absorption of fluid and solutes while restricting pathogen access to…”
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Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair by Luissint, Anny-Claude, Parkos, Charles A, Nusrat, Asma

“…The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic, permeable barrier allowing for selective absorption of…”
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RhoGTPases, actomyosin signaling and regulation of the Epithelial Apical Junctional Complex by Quiros, Miguel, Nusrat, Asma

“…Epithelial cells form regulated and selective barriers between distinct tissue compartments. The Apical Junctional Complex (AJC) consisting of the tight…”
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Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair by Quirós, Miguel, Nusrat, Asma

“…The gastrointestinal mucosa, structurally formed by the epithelium and lamina propria, serves as a selective barrier that separates luminal contents from the…”
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Saving Problematic Mucosae: SPMs in Intestinal Mucosal Inflammation and Repair by Quiros, Miguel, Nusrat, Asma

“…The intestinal mucosa serves as a highly selective barrier that allows the absorption of nutrients and water while restricting microbiota access to tissues…”
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The life and death of epithelia during inflammation: lessons learned from the gut by Koch, Stefan, Nusrat, Asma

“…Epithelial cells form protective barriers that physically separate an organism from the outside world. Rather than being merely static, impregnable shields,…”
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Claudin switching: Physiological plasticity of the Tight Junction by Capaldo, Christopher T., Nusrat, Asma

“…•The paracellular barrier is provided by Tight Junctions.•Tight Junction barrier properties are determined by claudin expression.•There are multiple claudins…”
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The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis by Kitamoto, Sho, Nagao-Kitamoto, Hiroko, Jiao, Yizu, Gillilland, Merritt G., Hayashi, Atsushi, Imai, Jin, Sugihara, Kohei, Miyoshi, Mao, Brazil, Jennifer C., Kuffa, Peter, Hill, Brett D., Rizvi, Syed M., Wen, Fei, Bishu, Shrinivas, Inohara, Naohiro, Eaton, Kathryn A., Nusrat, Asma, Lei, Yu L., Giannobile, William V., Kamada, Nobuhiko

“…The precise mechanism by which oral infection contributes to the pathogenesis of extra-oral diseases remains unclear. Here, we report that periodontal…”
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IL-10 produced by macrophages regulates epithelial integrity in the small intestine by Morhardt, Tina L., Hayashi, Atsushi, Ochi, Takanori, Quirós, Miguel, Kitamoto, Sho, Nagao-Kitamoto, Hiroko, Kuffa, Peter, Atarashi, Koji, Honda, Kenya, Kao, John Y., Nusrat, Asma, Kamada, Nobuhiko

“…Macrophages (Mϕs) are known to be major producers of the anti-inflammatory cytokine interleukin-10 (IL-10) in the intestine, thus playing an important role in…”
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Synthetic hydrogels for human intestinal organoid generation and colonic wound repair by Cruz-Acuña, Ricardo, Quirós, Miguel, Farkas, Attila E., Dedhia, Priya H., Huang, Sha, Siuda, Dorothée, García-Hernández, Vicky, Miller, Alyssa J., Spence, Jason R., Nusrat, Asma, García, Andrés J.

“…In vitro differentiation of human intestinal organoids (HIOs) from pluripotent stem cells is an unparalleled system for creating complex, multicellular…”
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Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration by Abo, Hirohito, Chassaing, Benoit, Harusato, Akihito, Quiros, Miguel, Brazil, Jennifer C., Ngo, Vu L., Viennois, Emilie, Merlin, Didier, Gewirtz, Andrew T., Nusrat, Asma, Denning, Timothy L.

“…Gut microbiota and their metabolites are instrumental in regulating intestinal homeostasis. However, early-life microbiota associated influences on intestinal…”
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Role of the intestinal barrier in inflammatory bowel disease by Laukoetter, Mike G, Nava, Porfirio, Nusrat, Asma

“…A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the interstitium. The single layer of intestinal…”
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Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol by Rahman, Khalidur, Desai, Chirayu, Iyer, Smita S, Thorn, Natalie E, Kumar, Pradeep, Liu, Yunshan, Smith, Tekla, Neish, Andrew S, Li, Hongliang, Tan, Shiyun, Wu, Pengbo, Liu, Xiaoxiong, Yu, Yuanjie, Farris, Alton B, Nusrat, Asma, Parkos, Charles A, Anania, Frank A

“…Background & Aims There is evidence from clinical studies that compromised intestinal epithelial permeability contributes to the development of nonalcoholic…”
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Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair by Leoni, Giovanna, Neumann, Philipp-Alexander, Kamaly, Nazila, Quiros, Miguel, Nishio, Hikaru, Jones, Hefin R, Sumagin, Ronen, Hilgarth, Roland S, Alam, Ashfaqul, Fredman, Gabrielle, Argyris, Ioannis, Rijcken, Emile, Kusters, Dennis, Reutelingsperger, Chris, Perretti, Mauro, Parkos, Charles A, Farokhzad, Omid C, Neish, Andrew S, Nusrat, Asma

“…Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in…”
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Probiotic Bacteria Induce Maturation of Intestinal Claudin 3 Expression and Barrier Function by Patel, Ravi M, Myers, Loren S, Kurundkar, Ashish R, Maheshwari, Akhil, Nusrat, Asma, Lin, Patricia W

“…An immature intestinal epithelial barrier may predispose infants and children to many intestinal inflammatory diseases, such as infectious enteritis,…”
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Dynamic Regulation of Epithelial Cell Fate and Barrier Function by Intercellular Junctions by Koch, Stefan, Nusrat, Asma

“…In the intestine, a single layer of epithelial cells effectively separates potentially harmful luminal content from the underlying tissue. The importance of an…”
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Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function by Raya-Sandino, Arturo, Lozada-Soto, Kristen M., Rajagopal, Nandhini, Garcia-Hernandez, Vicky, Luissint, Anny-Claude, Brazil, Jennifer C., Cui, Guiying, Koval, Michael, Parkos, Charles A., Nangia, Shikha, Nusrat, Asma

“…Claudin family tight junction proteins form charge- and size-selective paracellular channels that regulate epithelial barrier function. In the gastrointestinal…”
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JAM-related proteins in mucosal homeostasis and inflammation by Luissint, Anny-Claude, Nusrat, Asma, Parkos, Charles A.

“…Mucosal surfaces are lined by epithelial cells that form a physical barrier protecting the body against external noxious substances and pathogens. At a…”
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Inflammatory Bowel Disease and the Apical Junctional Complex by BRUEWER, MATTHIAS, SAMARIN, STANISLAV, NUSRAT, ASMA

“…:  A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the underlying interstitium. This intestinal barrier…”
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Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo by Reed, Michelle, Luissint, Anny-Claude, Azcutia, Veronica, Fan, Shuling, O’Leary, Monique N., Quiros, Miguel, Brazil, Jennifer, Nusrat, Asma, Parkos, Charles A.

“…CD47 is a ubiquitously expressed transmembrane glycoprotein that regulates inflammatory responses and tissue repair. Here, we show that normal mice treated…”
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