Search Results - "Nurnberger Jr, John"

Autism genetics: opportunities and challenges for clinical translation by Vorstman, Jacob A. S., Parr, Jeremy R., Moreno-De-Luca, Daniel, Anney, Richard J. L., Nurnberger Jr, John I., Hallmayer, Joachim F.

“…Key Points A rapidly growing list of rare genetic causes of autism spectrum disorders (ASDs) is being identified, giving insights into the underlying biology…”
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Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence by Zlojutro, Mark, Manz, Niklas, Rangaswamy, Madhavi, Xuei, Xiaoling, Flury-Wetherill, Leah, Koller, Daniel, Bierut, Laura J., Goate, Alison, Hesselbrock, Victor, Kuperman, Samuel, Nurnberger Jr, John, Rice, John P., Schuckit, Marc A., Foroud, Tatiana, Edenberg, Howard J., Porjesz, Bernice, Almasy, Laura

“…Event‐related brain oscillations (EROs) represent highly heritable neuroelectrical correlates of human perception and cognitive performance that exhibit marked…”
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DSM-5 cannabis use disorder: A phenotypic and genomic perspective by Agrawal, Arpana, Lynskey, Michael T, Bucholz, Kathleen K, Kapoor, Manav, Almasy, Laura, Dick, Danielle M, Edenberg, Howard J, Foroud, Tatiana, Goate, Alison, Hancock, Dana B, Hartz, Sarah, Johnson, Eric O, Hesselbrock, Victor, Kramer, John R, Kuperman, Samuel, Nurnberger Jr., John I, Schuckit, Marc, Bierut, Laura J

“…Abstract Background We explore the factor structure of DSM-5 cannabis use disorders, examine its prevalence across European- and African-American respondents…”
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Neuropeptide Y Receptor Genes Are Associated With Alcohol Dependence, Alcohol Withdrawal Phenotypes, and Cocaine Dependence by Wetherill, Leah, Schuckit, Marc A., Hesselbrock, Victor, Xuei, Xiaoling, Liang, Tiebing, Dick, Danielle M., Kramer, John, Nurnberger Jr, John I., Tischfield, Jay A., Porjesz, Bernice, Edenberg, Howard J., Foroud, Tatiana

“…Background:  Several lines of evidence in both human and animal studies suggest that variation in neuropeptide Y (NPY) or its receptor genes (NPY1R, NPY2R and…”
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Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression by Culverhouse, Robert C, Bowes, Lucy, Breslau, Naomi, Nurnberger, Jr, John I, Burmeister, Margit, Fergusson, David M, Munafò, Marcus, Saccone, Nancy L, Bierut, Laura J

“…Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report…”
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Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence by Agrawal, Arpana, Wetherill, Leah, Dick, Danielle M., Xuei, Xiaoling, Hinrichs, Anthony, Hesselbrock, Victor, Kramer, John, Nurnberger Jr, John I., Schuckit, Marc, Bierut, Laura J., Edenberg, Howard J., Foroud, Tatiana

“…Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14‐15 is an excellent candidate gene for…”
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Under the influence of genetics: how transdisciplinarity leads us to rethink social pathways to illness by Pescosolido, Bernice A, Perry, Brea L, Long, J Scott, Martin, Jack K, Nurnberger, Jr, John I, Hesselbrock, Victor

“…This article describes both sociological and genetic theories of illness causation and derives propositions expected under each and under a transdisciplinary…”
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A genome-wide association study of DSM-IV cannabis dependence by Agrawal, Arpana, Lynskey, Michael T., Hinrichs, Anthony, Grucza, Richard, Saccone, Scott F., Krueger, Robert, Neuman, Rosalind, Howells, William, Fisher, Sherri, Fox, Louis, Cloninger, Robert, Dick, Danielle M., Doheny, Kimberly F., Edenberg, Howard J., Goate, Alison M., Hesselbrock, Victor, Johnson, Eric, Kramer, John, Kuperman, Samuel, Nurnberger Jr, John I., Pugh, Elizabeth, Schuckit, Marc, Tischfield, Jay, Rice, John P., Bucholz, Kathleen K., Bierut, Laura J.

“…ABSTRACT Despite twin studies showing that 50–70% of variation in DSM‐IV cannabis dependence is attributable to heritable influences, little is known of…”
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Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk by Dick, Danielle M., Agrawal, Arpana, Wang, Jen C., Hinrichs, Anthony, Bertelsen, Sarah, Bucholz, Kathleen K., Schuckit, Marc, Kramer, John, Nurnberger Jr, John, Tischfield, Jay, Edenberg, Howard J., Goate, Alison, Bierut, Laura J.

“…ABSTRACT Background  Twin data suggest that alcohol dependence comorbid with illicit drug dependence represents a more heritable form of the disorder. In the…”
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Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts by Dick, Danielle M., Meyers, Jacquelyn, Aliev, Fazil, Nurnberger Jr, John, Kramer, John, Kuperman, Sam, Porjesz, Bernice, Tischfield, Jay, Edenberg, Howard J., Foroud, Tatiana, Schuckit, Marc, Goate, Alison, Hesselbrock, Victor, Bierut, Laura

“…Twin studies provide strong evidence that there is a shared genetic liability that predisposes to a number of different psychiatric outcomes related to…”
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Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition by Jones, Kevin A., Porjesz, Bernice, Almasy, Laura, Bierut, Laura, Goate, Alison, Wang, Jen C., Dick, Danielle M., Hinrichs, Anthony, Kwon, Jennifer, Rice, John P., Rohrbaugh, John, Stock, Heather, Wu, William, Bauer, Lance O., Chorlian, David B., Crowe, Raymond R., Edenberg, Howard J., Foroud, Tatiana, Hesselbrock, Victor, Kuperman, Samuel, Nurnberger Jr, John, O'Connor, Sean J., Schuckit, Marc A., Stimus, Arthur T., Tischfield, Jay A., Reich, Theodore, Begleiter, Henri

“…Event-related oscillations (ERO) offer an alternative theoretical and methodological approach to the analysis of event-related EEG responses. The P300…”
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Lack of Association of Alcohol Dependence and Habitual Smoking With Catechol-O-methyltransferase by Foroud, Tatiana, Wetherill, Leah Flury, Dick, Danielle M., Hesselbrock, Victor, Nurnberger, Jr, John I., Kramer, John, Tischfield, Jay, Schuckit, Marc, Bierut, Laura J., Xuei, Xiaoling, Edenberg, Howard J.

“…Objective:  To test whether variation in the gene encoding the enzyme catechol‐O‐methyltransferase (COMT), which catalyzes the breakdown of dopamine and other…”
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The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development by Krystal, Andrew D., Pizzagalli, Diego A., Mathew, Sanjay J., Sanacora, Gerard, Keefe, Richard, Song, Allen, Calabrese, Joseph, Goddard, Andrew, Goodman, Wayne, Lisanby, Sarah H., Smoski, Moria, Weiner, Richard, Iosifescu, Dan, Nurnberger, John, Szabo, Steven, Murrough, James, Shekhar, Anantha, Potter, William

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Examining the association of familial and social stress, trauma, and support on mood, anxiety, and behavioral symptoms and diagnoses in youth at risk for bipolar disorder and controls by Kamali, Masoud, Stapp, Emma K., Fullerton, Janice M., Ghaziuddin, Neera, Hulvershorn, Leslie, McInnis, Melvin G., Mitchell, Philip B., Roberts, Gloria, Wilcox, Holly C., Nurnberger, John I.

“…Youth with a family history of bipolar disorder (At-Risk) have a higher risk of developing psychiatric disorders and experiencing environmental stressors than…”
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Suggestive Linkage on Chromosome 1 for a Quantitative Alcohol-Related Phenotype by Dick, Danielle M., Nurnberger Jr, John, Edenberg, Howard J., Goate, Alison, Crowe, Ray, Rice, John, Bucholz, Kathleen K., Kramer, John, Schuckit, Marc A., Smith, Tom L., Porjesz, Bernice, Begleiter, Henri, Hesselbrock, Victor, Foroud, Tatiana

“…Background Alcohol dependence is a clinically and etiologically heterogeneous disorder. Accordingly, a variety of subtypes of alcohol‐dependent individuals…”
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A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency by Thomas, Nathaniel S., Gillespie, Nathan A., Chan, Grace, Edenberg, Howard J., Kamarajan, Chella, Kuo, Sally I-Chun, Miller, Alex P., Nurnberger, John I., Tischfield, Jay, Dick, Danielle M., Salvatore, Jessica E.

“…Contemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. We applied…”
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Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study by Darrow, Sabrina M., Pizzagalli, Diego A., Smoski, Moria, Mathew, Sanjay J., Nurnberger, John, Lisanby, Sarah H., Iosifescu, Dan, Murrough, James W., Yang, Hongqiu, Weiner, Richard D., Sanacora, Gerard, Keefe, Richard S.E., Song, Allen, Goodman, Wayne, Whitton, Alexis E., Potter, William Z., Krystal, Andrew D.

“…Growing evidence indicates that anhedonia is a multifaceted construct. This study examined the possibility of identifying subgroups of people with anhedonia…”
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Genome-Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11 by Edenberg, Howard J., Koller, Daniel L., Xuei, Xiaoling, Wetherill, Leah, McClintick, Jeanette N., Almasy, Laura, Bierut, Laura J., Bucholz, Kathleen K., Goate, Alison, Aliev, Fazil, Dick, Danielle, Hesselbrock, Victor, Hinrichs, Anthony, Kramer, John, Kuperman, Sam, Nurnberger Jr, John I., Rice, John P., Schuckit, Marc A., Taylor, Robert, Todd Webb, B., Tischfield, Jay A., Porjesz, Bernice, Foroud, Tatiana

“…Background:  Alcohol dependence is a complex disease, and although linkage and candidate gene studies have identified several genes associated with the risk…”
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Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders by Saenz de Viteri, Stacey, Zhang, Jian, Johnson, Emma C., Barr, Peter B., Edenberg, Howard J., Hesselbrock, Victor M., Nurnberger, John I., Pandey, Ashwini K., Kamarajan, Chella, Kinreich, Sivan, Tischfield, Jay A., Plawecki, Martin H., Kramer, John R., Lai, Dongbing, Kuperman, Samuel, Chan, Grace, McCutcheon, Vivia V., Bucholz, Kathleen K., Porjesz, Bernice, Meyers, Jacquelyn L.

“…Recent genome-wide association studies (GWAS) have identified genetic markers of post-traumatic stress disorder (PTSD) in civilian and military populations…”
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A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks by Kapoor, Manav, Wang, Jen-Chyong, Wetherill, Leah, Le, Nhung, Bertelsen, Sarah, Hinrichs, Anthony L., Budde, John, Agrawal, Arpana, Bucholz, Kathleen, Dick, Danielle, Harari, Oscar, Hesselbrock, Victor, Kramer, John, Nurnberger, John I., Rice, John, Saccone, Nancy, Schuckit, Marc, Tischfield, Jay, Porjesz, Bernice, Edenberg, Howard J., Bierut, Laura, Foroud, Tatiana, Goate, Alison

“…Maximum number of alcoholic drinks consumed in a 24-h period (maxdrinks) is a heritable (>50 %) trait and is strongly correlated with vulnerability to…”
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