Search Results - "Nurnberger, John I."

Autism genetics: opportunities and challenges for clinical translation by Vorstman, Jacob A. S., Parr, Jeremy R., Moreno-De-Luca, Daniel, Anney, Richard J. L., Nurnberger Jr, John I., Hallmayer, Joachim F.

“…Key Points A rapidly growing list of rare genetic causes of autism spectrum disorders (ASDs) is being identified, giving insights into the underlying biology…”
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genome-wide association study of alcohol dependence by Bierut, Laura J, Agrawal, Arpana, Bucholz, Kathleen K, Doheny, Kimberly F, Laurie, Cathy, Pugh, Elizabeth, Fisher, Sherri, Fox, Louis, Howells, William, Bertelsen, Sarah, Hinrichs, Anthony L, Almasy, Laura, Breslau, Naomi, Culverhouse, Robert C, Dick, Danielle M, Edenberg, Howard J, Foroud, Tatiana, Grucza, Richard A, Hatsukami, Dorothy, Hesselbrock, Victor, Johnson, Eric O, Kramer, John, Krueger, Robert F, Kuperman, Samuel, Lynskey, Michael, Mann, Karl, Neuman, Rosalind J, Nöthen, Markus M, Nurnberger, John I. Jr, Porjesz, Bernice, Ridinger, Monika, Saccone, Nancy L, Saccone, Scott F, Schuckit, Marc A, Tischfield, Jay A, Wang, Jen C, Rietschel, Marcella, Goate, Alison M, Rice, John P

“…Excessive alcohol consumption is one of the leading causes of preventable death in the United States. Approximately 14% of those who use alcohol meet criteria…”
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New analyses provide supportive evidence for specific genes related to bipolar disorder by Nurnberger, John I.

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Examining the association of familial and social stress, trauma, and support on mood, anxiety, and behavioral symptoms and diagnoses in youth at risk for bipolar disorder and controls by Kamali, Masoud, Stapp, Emma K., Fullerton, Janice M., Ghaziuddin, Neera, Hulvershorn, Leslie, McInnis, Melvin G., Mitchell, Philip B., Roberts, Gloria, Wilcox, Holly C., Nurnberger, John I.

“…Youth with a family history of bipolar disorder (At-Risk) have a higher risk of developing psychiatric disorders and experiencing environmental stressors than…”
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Polygenic risk scores in psychiatry: Will they be useful for clinicians? [version 1; peer review: 4 approved] by Fullerton, Janice M, Nurnberger, John I

“…Major psychiatric disorders are heritable but they are genetically complex. This means that, with certain exceptions, single gene markers will not be helpful…”
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Genome-Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11 by Edenberg, Howard J., Koller, Daniel L., Xuei, Xiaoling, Wetherill, Leah, McClintick, Jeanette N., Almasy, Laura, Bierut, Laura J., Bucholz, Kathleen K., Goate, Alison, Aliev, Fazil, Dick, Danielle, Hesselbrock, Victor, Hinrichs, Anthony, Kramer, John, Kuperman, Sam, Nurnberger Jr, John I., Rice, John P., Schuckit, Marc A., Taylor, Robert, Todd Webb, B., Tischfield, Jay A., Porjesz, Bernice, Foroud, Tatiana

“…Background:  Alcohol dependence is a complex disease, and although linkage and candidate gene studies have identified several genes associated with the risk…”
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Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans by Lai, Dongbing, Schwantes-An, Tae-Hwi, Abreu, Marco, Chan, Grace, Hesselbrock, Victor, Kamarajan, Chella, Liu, Yunlong, Meyers, Jacquelyn L., Nurnberger, John I., Plawecki, Martin H., Wetherill, Leah, Schuckit, Marc, Zhang, Pengyue, Edenberg, Howard J., Porjesz, Bernice, Agrawal, Arpana, Foroud, Tatiana

“…Genome-wide association studies (GWAS) in admixed populations such as African Americans (AA) have limited sample sizes, resulting in poor performance of…”
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A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency by Thomas, Nathaniel S., Gillespie, Nathan A., Chan, Grace, Edenberg, Howard J., Kamarajan, Chella, Kuo, Sally I-Chun, Miller, Alex P., Nurnberger, John I., Tischfield, Jay, Dick, Danielle M., Salvatore, Jessica E.

“…Contemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. We applied…”
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Rare variants in neuronal excitability genes influence risk for bipolar disorder by Amenta, Seth A., Szelinger, Szabolcs, Glusman, Gustavo, Ashworth, Justin, Hou, Liping, Akula, Nirmala, Shekhtman, Tatyana, Badner, Judith A., Brunkow, Mary E., Mauldin, Denise E., Stittrich, Anna-Barbara, Rouleau, Katherine, Detera-Wadleigh, Sevilla D., Nurnberger, John I., Edenberg, Howard J., Gershon, Elliot S., Schork, Nicholas, Price, Nathan D., Gelinas, Richard, Hood, Leroy, Craig, David, McMahon, Francis J., Kelsoe, John R., Roach, Jared C.

“…We sequenced the genomes of 200 individuals from 41 families multiply affected with bipolar disorder (BD) to identify contributions of rare variants to genetic…”
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Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases by Kapoor, Manav, Chao, Michael J., Johnson, Emma C., Novikova, Gloriia, Lai, Dongbing, Meyers, Jacquelyn L., Schulman, Jessica, Nurnberger, John I., Porjesz, Bernice, Liu, Yunlong, Foroud, Tatiana, Edenberg, Howard J., Marcora, Edoardo, Agrawal, Arpana, Goate, Alison

“…Identification of causal variants and genes underlying genome-wide association study (GWAS) loci is essential to understand the biology of alcohol use disorder…”
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Common genetic variants on 5p14.1 associate with autism spectrum disorders by Hakonarson, Hakon, Wang, Kai, Zhang, Haitao, Ma, Deqiong, Bucan, Maja, Glessner, Joseph T, Abrahams, Brett S, Salyakina, Daria, Imielinski, Marcin, Bradfield, Jonathan P, Sleiman, Patrick M. A, Kim, Cecilia E, Hou, Cuiping, Frackelton, Edward, Chiavacci, Rosetta, Takahashi, Nagahide, Sakurai, Takeshi, Rappaport, Eric, Lajonchere, Clara M, Munson, Jeffrey, Estes, Annette, Korvatska, Olena, Piven, Joseph, Sonnenblick, Lisa I, Alvarez Retuerto, Ana I, Herman, Edward I, Dong, Hongmei, Hutman, Ted, Sigman, Marian, Ozonoff, Sally, Klin, Ami, Owley, Thomas, Sweeney, John A, Brune, Camille W, Cantor, Rita M, Bernier, Raphael, Gilbert, John R, Cuccaro, Michael L, McMahon, William M, Miller, Judith, State, Matthew W, Wassink, Thomas H, Coon, Hilary, Levy, Susan E, Schultz, Robert T, Nurnberger, John I, Haines, Jonathan L, Sutcliffe, James S, Cook, Edwin H, Minshew, Nancy J, Buxbaum, Joseph D, Dawson, Geraldine, Grant, Struan F. A, Geschwind, Daniel H, Pericak-Vance, Margaret A, Schellenberg, Gerard D

“…Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and neuropsychiatric disorders characterized by deficits in verbal…”
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21st-Century Genetics in Psychiatric Residency Training: How Do We Get There? by Besterman, Aaron D, Moreno-De-Luca, Daniel, Nurnberger, Jr, John I

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A Genetic Locus Associated With Depression: The Iceberg Begins to Melt by Nurnberger, John I.

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Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders by Saenz de Viteri, Stacey, Zhang, Jian, Johnson, Emma C., Barr, Peter B., Edenberg, Howard J., Hesselbrock, Victor M., Nurnberger, John I., Pandey, Ashwini K., Kamarajan, Chella, Kinreich, Sivan, Tischfield, Jay A., Plawecki, Martin H., Kramer, John R., Lai, Dongbing, Kuperman, Samuel, Chan, Grace, McCutcheon, Vivia V., Bucholz, Kathleen K., Porjesz, Bernice, Meyers, Jacquelyn L.

“…Recent genome-wide association studies (GWAS) have identified genetic markers of post-traumatic stress disorder (PTSD) in civilian and military populations…”
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A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks by Kapoor, Manav, Wang, Jen-Chyong, Wetherill, Leah, Le, Nhung, Bertelsen, Sarah, Hinrichs, Anthony L., Budde, John, Agrawal, Arpana, Bucholz, Kathleen, Dick, Danielle, Harari, Oscar, Hesselbrock, Victor, Kramer, John, Nurnberger, John I., Rice, John, Saccone, Nancy, Schuckit, Marc, Tischfield, Jay, Porjesz, Bernice, Edenberg, Howard J., Bierut, Laura, Foroud, Tatiana, Goate, Alison

“…Maximum number of alcoholic drinks consumed in a 24-h period (maxdrinks) is a heritable (>50 %) trait and is strongly correlated with vulnerability to…”
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Autism genome-wide copy number variation reveals ubiquitin and neuronal genes by Minshew, Nancy J, Thomas, Kelly, Nurnberger, John I, Crawford, Emily L, Otieno, Frederick, Dawson, Geraldine, Posey, David J, Annaiah, Kiran, Glaberson, Wendy, Wood, Shawn, Meyer, Kacie J, Sleiman, Patrick M. A, Miller, Judith, Munson, Jeffrey, Kim, Cecilia E, Bradfield, Jonathan P, Soorya, Latha, Frackelton, Edward C, Bucan, Maja, Sakurai, Takeshi, Hou, Cuiping, Anagnostou, Evdokia, Piven, Joseph, Schultz, Robert T, Zhang, Haitao, Cook, Edwin H, Schellenberg, Gerard D, Wang, Kai, Flory, James, Rudd, Danielle S, Sweeney, John A, Zurawiecki, Danielle, Grant, Struan F. A, Michaels, Shana, Levy, Susan E, Chiavacci, Rosetta, McMahon, William M, Brune, Camille W, Korvatska, Olena, Klei, Lambertus, Cai, Guiqing, McDougle, Christopher J, Hakonarson, Hakon, Kolevzon, Alexander, Garris, Maria, Silverman, Jeremy M, Wassink, Thomas H, Owley, Thomas, Glessner, Joseph T, Sutcliffe, James S, Reichert, Jennifer, Davis, Lea K, Bernier, Raphael, Game, Rachel M, Devlin, Bernie, Coon, Hilary, Imielinski, Marcin, Estes, Annette, Buxbaum, Joseph D

“…Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies focusing on candidate genes or…”
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Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence by Andersen, Allan M, Pietrzak, Robert H, Kranzler, Henry R, Ma, Li, Zhou, Hang, Liu, Xiaoming, Kramer, John, Kuperman, Samuel, Edenberg, Howard J, Nurnberger, Jr, John I, Rice, John P, Tischfield, Jay A, Goate, Alison, Foroud, Tatiana M, Meyers, Jacquelyn L, Porjesz, Bernice, Dick, Danielle M, Hesselbrock, Victor, Boerwinkle, Eric, Southwick, Steven M, Krystal, John H, Weissman, Myrna M, Levinson, Douglas F, Potash, James B, Gelernter, Joel, Han, Shizhong

“…Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burdens, and they are frequently comorbid…”
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Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach by Hu, Bo, Cha, Jungwon, Fullerton, Janice M., Hesam-Shariati, Sonia, Nakamura, Kunio, Nurnberger, John I., Anand, Amit

“…We investigated gene–environment effects on structural brain endophenotype in bipolar disorder (BD) using a novel method of combining polygenic risk scores…”
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What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics by Nurnberger, Jr, John I, Austin, Jehannine, Berrettini, Wade H, Besterman, Aaron D, DeLisi, Lynn E, Grice, Dorothy E, Kennedy, James L, Moreno-De-Luca, Daniel, Potash, James B, Ross, David A, Schulze, Thomas G, Zai, Gwyneth

“…The International Society of Psychiatric Genetics (ISPG) created a Residency Education Committee with the purpose of identifying key genetic knowledge that…”
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A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence by Grucza, Richard A, Wang, Jen C, Stitzel, Jerry A, Hinrichs, Anthony L, Saccone, Scott F, Saccone, Nancy L, Bucholz, Kathleen K, Cloninger, C. Robert, Neuman, Rosalind J, Budde, John P, Fox, Louis, Bertelsen, Sarah, Kramer, John, Hesselbrock, Victor, Tischfield, Jay, Nurnberger, John I, Almasy, Laura, Porjesz, Bernice, Kuperman, Samuel, Schuckit, Marc A, Edenberg, Howard J, Rice, John P, Goate, Alison M, Bierut, Laura J

“…Background A nonsynonymous coding polymorphism, rs16969968, of the CHRNA5 gene that encodes the alpha-5 subunit of the nicotinic acetylcholine receptor (nAChR)…”
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