Search Results - "Nurnberg, Bernd"

In Vivo Inhibition of TRPC6 by SH045 Attenuates Renal Fibrosis in a New Zealand Obese (NZO) Mouse Model of Metabolic Syndrome by Zheng, Zhihuang, Xu, Yao, Krügel, Ute, Schaefer, Michael, Grune, Tilman, Nürnberg, Bernd, Köhler, May-Britt, Gollasch, Maik, Tsvetkov, Dmitry, Markó, Lajos

“…Metabolic syndrome is a significant worldwide public health challenge and is inextricably linked to adverse renal and cardiovascular outcomes. The inhibition…”
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Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome by Mauriac, Stephanie A., Hien, Yeri E., Bird, Jonathan E., Carvalho, Steve Dos-Santos, Peyroutou, Ronan, Lee, Sze Chim, Moreau, Maite M., Blanc, Jean-Michel, Gezer, Aysegul, Medina, Chantal, Thoumine, Olivier, Beer-Hammer, Sandra, Friedman, Thomas B., Rüttiger, Lukas, Forge, Andrew, Nürnberg, Bernd, Sans, Nathalie, Montcouquiol, Mireille

“…Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive neurological disorder characterized by early-onset sensorineural deafness…”
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Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism by Mays, Lauren E, Ammon-Treiber, Susanne, Mothes, Benedikt, Alkhaled, Mohammed, Rottenberger, Jennifer, Müller-Hermelink, Eva Sophie, Grimm, Melanie, Mezger, Markus, Beer-Hammer, Sandra, von Stebut, Esther, Rieber, Nikolaus, Nürnberg, Bernd, Schwab, Matthias, Handgretinger, Rupert, Idzko, Marco, Hartl, Dominik, Kormann, Michael S D

“…Chemically modified mRNA is capable of inducing therapeutic levels of protein expression while circumventing the threat of genomic integration often associated…”
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Bivalent role of the phosphatidylinositol‐3‐kinase (PI3K) during influenza virus infection and host cell defence by Ehrhardt, Christina, Marjuki, Henju, Wolff, Thorsten, Nürnberg, Bernd, Planz, Oliver, Pleschka, Stephan, Ludwig, Stephan

“…Summary Infections with influenza A viruses result in the activation of a variety of intracellular signalling pathways. Recent findings suggest that in…”
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Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton by Ezan, Jerome, Lasvaux, Léa, Gezer, Aysegul, Novakovic, Ana, May-Simera, Helen, Belotti, Edwige, Lhoumeau, Anne-Catherine, Birnbaumer, Lutz, Beer-Hammer, Sandra, Borg, Jean-Paul, Le Bivic, André, Nürnberg, Bernd, Sans, Nathalie, Montcouquiol, Mireille

“…It has been shown that planar cell polarity (PCP) signalling and cilium positioning are linked. Montcouquiol and colleagues now show that G-protein signalling,…”
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Fluorescent Ly6G antibodies determine macrophage phagocytosis of neutrophils and alter the retrieval of neutrophils in mice by Bucher, Kirsten, Schmitt, Fee, Autenrieth, Stella E., Dillmann, Inken, Nürnberg, Bernd, Schenke‐Layland, Katja, Beer‐Hammer, Sandra

“…Coupled fluorochromes alter physiological functions of neutrophil targeting anti‐Ly6G antibodies. Fluorescently labeled Ly6G antibodies enable the tracking of…”
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Platelets and the Cybernetic Regulation of Ischemic Inflammatory Responses through PNC Formation Regulated by Extracellular Nucleotide Metabolism and Signaling by Granja, Tiago F, Köhler, David, Leiss, Veronika, Eggstein, Claudia, Nürnberg, Bernd, Rosenberger, Peter, Beer-Hammer, Sandra

“…Ischemic events are associated with severe inflammation and are here referred to as ischemic inflammatory response (IIR). Recent studies identified the…”
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Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2) by Leiss, Veronika, Flockerzie, Katarina, Novakovic, Ana, Rath, Michaela, Schönsiegel, Annika, Birnbaumer, Lutz, Schürmann, Annette, Harteneck, Christian, Nürnberg, Bernd

“…Bordetella pertussis toxin (PTx), also known as islet-activating protein, induces insulin secretion by ADP-ribosylation of inhibitory G proteins. PTx-induced…”
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Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice by Grenz, Almut, Bauerle, Jessica D, Dalton, Julee H, Ridyard, Douglas, Badulak, Alexander, Tak, Eunyoung, McNamee, Eóin N, Clambey, Eric, Moldovan, Radu, Reyes, German, Klawitter, Jost, Ambler, Kelly, Magee, Kristann, Christians, Uwe, Brodsky, Kelley S, Ravid, Katya, Choi, Doo-Sup, Wen, Jiaming, Lukashev, Dmitriy, Blackburn, Michael R, Osswald, Hartmut, Coe, Imogen R, Nürnberg, Bernd, Haase, Volker H, Xia, Yang, Sitkovsky, Michail, Eltzschig, Holger K

“…A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading…”
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Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia by Bucher, Kirsten, Schmitt, Fee, Mothes, Benedikt, Blumendeller, Carolin, Schäll, Daniel, Piekorz, Roland, Hirsch, Emilio, Nürnberg, Bernd, Beer-Hammer, Sandra

“…Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function…”
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PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane by Viard, Patricia, Butcher, Adrian J, Halet, Guillaume, Davies, Anthony, Nürnberg, Bernd, Heblich, Fay, Dolphin, Annette C

“…Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons;…”
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In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency by Mahiny, Azita J, Dewerth, Alexander, Mays, Lauren E, Alkhaled, Mohammed, Mothes, Benedikt, Malaeksefat, Emad, Loretz, Brigitta, Rottenberger, Jennifer, Brosch, Darina M, Reautschnig, Philipp, Surapolchai, Pacharapan, Zeyer, Franziska, Schams, Andrea, Carevic, Melanie, Bakele, Martina, Griese, Matthias, Schwab, Matthias, Nürnberg, Bernd, Beer-Hammer, Sandra, Handgretinger, Rupert, Hartl, Dominik, Lehr, Claus-Michael, Kormann, Michael S D

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The effect of platelet G proteins on platelet extravasation and tumor growth in the murine model of ovarian cancer by Cho, Min Soon, Li, Jiasong, Gonzalez-Delgado, Ricardo, Lee, Hani, Vasquez, Matthew, He, Tiancheng, He, Yunjie, Liu, Kai, Sasano, Tomoyuki, Nürnberg, Bernd, Sood, Anil K., Wong, Stephen T.C., Afshar-Kharghan, Vahid

“…We and other investigators have shown that platelets promote metastasis and the growth of tumors. Our rationale for conducting this study is that platelets'…”
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Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase by Stoyanov, Borislav, Volinia, Stefano, Hanck, Theodor, Rubio, Ignacio, Loubtchenkov, Michael, Malek, Daria, Stoyanova, Stefka, Vanhaesebroeck, Bart, Dhand, Ritu, Nürnberg, Bernd, Gierschik, Peter, Seedorf, Klaus, Hsuan, J. Justin, Waterfield, Michael D., Wetzker, Reinhard

“…Phosphoinositide-3 kinase activity is implicated in diverse cellular responses triggered by mammalian cell surface receptors and in the regulation of protein…”
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Phosphoinositide 3-Kinase Isoforms Selectively Couple Receptors to Vascular L-Type Ca2+ Channels by Macrez, Nathalie, Mironneau, Chantal, Carricaburu, Valérie, Quignard, Jean-François, Babich, Aleksei, Czupalla, Cornelia, Nürnberg, Bernd, Mironneau, Jean

“…Heterodimeric class I phosphoinositide 3-kinase (PI3K) has been shown to be involved in the stimulation of voltage-gated Ca channels by various mediators. In…”
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Analyses of Gnai3-iresGFP reporter mice reveal unknown Gαi3 expression sites by Leiss, Veronika, Reisinger, Ellen, Speidel, Annika, Beer-Hammer, Sandra, Nürnberg, Bernd

“…Inhibitory G proteins (G i proteins) are highly homologous but play distinct biological roles. However, their isoform-specific detection remains challenging…”
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Vasopressin-stimulated ORAI1 expression and store-operated Ca2+ entry in aortic smooth muscle cells by Zhu, Xuexue, Ma, Ke, Zhou, Kuo, Liu, Jibin, Nürnberg, Bernd, Lang, Florian

“…Vascular calcification may result from stimulation of osteogenic signalling with upregulation of the transcription factors CBFA1 , MSX2 and SOX9 , as well as…”
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Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels by Dembla, Sandeep, Behrendt, Marc, Mohr, Florian, Goecke, Christian, Sondermann, Julia, Schneider, Franziska M, Schmidt, Marlene, Stab, Julia, Enzeroth, Raissa, Leitner, Michael G, Nuñez-Badinez, Paulina, Schwenk, Jochen, Nürnberg, Bernd, Cohen, Alejandro, Philipp, Stephan E, Greffrath, Wolfgang, Bünemann, Moritz, Oliver, Dominik, Zakharian, Eleonora, Schmidt, Manuela, Oberwinkler, Johannes

“…Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically available. Their action includes a strong central component, which…”
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Role of TRPC6 in kidney damage after acute ischemic kidney injury by Zheng, Zhihuang, Tsvetkov, Dmitry, Bartolomaeus, Theda Ulrike Patricia, Erdogan, Cem, Krügel, Ute, Schleifenbaum, Johanna, Schaefer, Michael, Nürnberg, Bernd, Chai, Xiaoning, Ludwig, Friedrich-Alexander, N’diaye, Gabriele, Köhler, May-Britt, Wu, Kaiyin, Gollasch, Maik, Markó, Lajos

“…Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation channel that controls influx of Ca 2+ and other monovalent cations…”
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Function, Regulation and Biological Roles of PI3Kγ Variants by Nürnberg, Bernd, Beer-Hammer, Sandra

“…Phosphatidylinositide 3-kinase (PI3K) γ is the only class IB PI3K member playing significant roles in the G-protein-dependent regulation of cell signaling in…”
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