Factors associated with high-risk HPV infection and cervical cancer screening methods among rural Uyghur women aged > 30 years in Xinjiang

Cervical cancer is the most common genital malignant tumor in women worldwide. However, the reliability of different detection methods may vary according to populations and epidemics. This study analyzed factors relevant to high-risk human papillomavirus (hrHPV) infection among rural Uyghur women ag...

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Bibliographic Details
Published in:	BMC cancer Vol. 18; no. 1; p. 1162
Main Authors:	Husaiyin, Sulaiya, Han, Lili, Wang, Lin, Ma, Chunhua, Ainiwaer, Zumurelaiti, Rouzi, Nuermanguli, Akemujiang, Mireguli, Simayil, Hatiguli, Aniwa, Zumulaiti, Nurimanguli, Rouzi, Niyazi, Mayinuer
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 23-11-2018 BioMed Central BMC
Subjects:	Biopsy Cancer screening Cellular biology Cervical cancer Cervical epithelial lesion Cervix Colposcopy Complications and side effects Deoxyribonucleic acid Developing countries Diagnosis DNA Human papillomavirus Human papillomavirus infection Infections LDCs Medical screening Methods Mortality Papillomavirus infections Population studies Prevention Risk factors Rural areas Sexual intercourse Sexual partners Uyghur Womens health China Colposcopy Human papillomavirus infection Cervical cancer Uyghur Cervical epithelial lesion
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Summary:	Cervical cancer is the most common genital malignant tumor in women worldwide. However, the reliability of different detection methods may vary according to populations and epidemics. This study analyzed factors relevant to high-risk human papillomavirus (hrHPV) infection among rural Uyghur women aged > 30 years and evaluated the value of different screening methods for cervical precancerous lesions. From July 2015 to May 2016, 225 rural Uyghur women aged > 30 years were recruited from local health clinics throughout Pishan, Xinjiang, China. HrHPV DNA testing, colposcopy, biopsy of cervical precancerous lesions, and surveys were conducted. The results of different screening methods were compared, and factors associated with hrHPV infection were analyzed. The rates of hrHPV infection and cervical epithelial lesions were 9.3 and 1.8%, respectively. The area under the ROC curve was 0.538 (95% CI: 0.292, 0.784; P = 0.753) for the HPV test and 0.995 (95% CI: 0.988, 1.003; P < 0.001) for colposcopy. Factors associated with HPV infection included widowhood (OR = 13.601 (2.170, 85.263), P = 0.005) and ≥ 3 sexual partners in the past 5 years (OR = 16.808 (4.148, 68.101), P < 0.001). . Among rural Uyghur women aged > 30 years, the main factors for HPV infection include marriage and frequent sexual intercourse. Colposcopy has a higher screening value for cervical epithelial lesions than hrHPV testing.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-2407 1471-2407
DOI:	10.1186/s12885-018-5083-1