Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone

Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone

An experiment was conducted to determine the effect of corticosterone (CORT) administration on serum ovotransferrin (OVT), α1-acid glycoprotein (AGP), ceruloplasmin (CPN), and IL-6 concentrations, and brain heat shock protein (HSP) 70 expression in broiler chickens. From 14 to 20 d of age, equal num...

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Bibliographic Details
Published in:Poultry science Vol. 93; no. 12; pp. 3112 - 3118
Main Authors: Zulkifli, I, Najafi, P, Nurfarahin, A J, Soleimani, A F, Kumari, S, Aryani, A Anna, O'Reilly, E L, Eckersall, P D
Format: Journal Article
Language:English
Published: England 01-12-2014
Subjects:
Acute-Phase Proteins - genetics
Acute-Phase Proteins - metabolism
Animals
Chickens - blood
Corticosterone - pharmacology
Female
Gene Expression Regulation - drug effects
HSP70 Heat-Shock Proteins - genetics
HSP70 Heat-Shock Proteins - metabolism
Interleukin-6 - genetics
Interleukin-6 - metabolism
Stress, Physiological
heat shock protein 70
interleukin 6
corticosterone
acute phase protein
broiler
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Summary:An experiment was conducted to determine the effect of corticosterone (CORT) administration on serum ovotransferrin (OVT), α1-acid glycoprotein (AGP), ceruloplasmin (CPN), and IL-6 concentrations, and brain heat shock protein (HSP) 70 expression in broiler chickens. From 14 to 20 d of age, equal numbers of birds were subjected to either (i) daily intramuscular injection with CORT in ethanol:saline (1:1, vol/vol) at 6 mg/kg of BW, or (ii) daily intramuscular injection with 0.5 mL ethanol:saline (1:1, vol/vol; control). Blood samples were collected before CORT treatment (14 d old), 3 and 7 d after CORT injections, and 4 d after cessation of CORT administration for determination of serum levels of CORT, OVT, AGP, CPN, and IL-6. Brain samples (whole cerebrum) were collected to measure HSP 70 density. Although CORT administration significantly increased feed intake, weight gain was significantly depressed. Administration of CORT also increased CORT, OVT, CPN, AGP, IL-6, and HSP 70 expression. Four days following cessation of CORT administration, OVT declined to the basal level but not CPN and AGP. In conclusion, an elevation in CORT can induce an acute-phase response and HSP 70 expression. Thus, APP and HSP 70 may be of value as indicators of stress in poultry.
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ISSN:0032-5791
DOI:10.3382/ps.2014-04099