Search Results - "Nurden, A.T"

Inherited disorders of platelet function: selected updates by Nurden, A.T., Nurden, P.

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Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII by Wilcox, D. A., Shi, Q., Nurden, P., Haberichter, S. L., Rosenberg, J. B., Johnson, B. D., Nurden, A. T., Ii, G. C. White, Montgomery, R. R.

“…von Willebrand factor (VWF) is a complex plasma glycoprotein that modulates platelet adhesion at the site of a vascular injury, and it also serves as a carrier…”
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Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH by Gresele, P., Harrison, P., Gachet, C., Hayward, C., Kenny, D., Mezzano, D., Mumford, A. D., Nugent, D., Nurden, A. T., Cattaneo, M.

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Professor Gustav Victor Rudolph Born (29 July 1921 – 16 April 2018) by Nurden, A. T.

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Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey by Gresele, P., Harrison, P., Bury, L., Falcinelli, E., Gachet, C., Hayward, C. P., Kenny, D., Mezzano, D., Mumford, A. D., Nugent, D., Nurden, A. T., Orsini, S., Cattaneo, M.

“…Summary Background Diagnosis of inherited platelet function disorders (IPFDs) is important for appropriate management and to improve epidemiologic and clinical…”
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An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families by Matus, V., Valenzuela, G., Sáez, C. G., Hidalgo, P., Lagos, M., Aranda, E., Panes, O., Pereira, J., Pillois, X., Nurden, A. T., Mezzano, D.

“…Summary Background Glycoprotein VI (GPVI), 60–65 kDa, is a major collagen receptor on platelet membranes involved in adhesive and signaling responses. Mice…”
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Qualitative disorders of platelets and megakaryocytes by NURDEN, A. T.

“…Qualitative disorders of platelet function and production form a large group of rare diseases which cover a multitude of genetic defects that by and large have…”
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C560Rβ3 caused platelet integrin αIIbβ3 to bind fibrinogen continuously, but resulted in a severe bleeding syndrome and increased murine mortality by Fang, J., Nurden, P., North, P., Nurden, A. T., Du, L. M., Valentin, N., Wilcox, D. A.

“…Summary Background and objectives β3‐Deficient megakaryocytes were modified by human β3‐lentivirus transduction and transplantation to express sufficient…”
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Gene Therapy Targeting Synthesis of Coagulation Factor VIII in Platelets Reduces Bleeding in Canine Hemophilia A by Du, L.M, Franck, H.W.G, Merricks, E.P, Nurden, P, Jensen, E.S, Haberichter, S.L, Hawkins, T.B, Jacobi, P.M, Fang, J, Nichols, T.C, Koukouritaki, S.B, Shi, Q, Nurden, A.T, Montogomery, R.R, Cornetta, K, Wilcox, D.A

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Expression of platelet membrane glycoproteins and alpha‐granule proteins by a human erythroleukemia cell line (HEL) by Tabilio, A., Rosa, J.P., Testa, U., Kieffer, N., Nurden, A.T., Del Canizo, M.C., Breton‐Gorius, J., Vainchenker, W.

“…We demonstrate that HEL, a human erythroleukemic cell line, has numerous megakaryocytic markers which were markedly enhanced following the addition of the…”
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Glanzmann thrombasthenia: the need for epidemiological studies by NURDEN, A. T.

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An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis by NURDEN, P., TANDON, N., TAKIZAWA, H., COUZI, L., MOREL, D., FIORE, M., PILLOIS, X., LOYAU, S., JANDROT‐PERRUS, M., NURDEN, A. T.

“…Background: GPVI is a major platelet collagen signaling receptor. In rare cases of immune thrombocytopenic purpura (ITP), autoantibodies to GPVI result in…”
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Does ATP act through P2X1 receptors to regulate platelet activation and thrombus formation? by NURDEN, A. T.

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Altered megakaryocytopoiesis in von Willebrand type 2B disease by NURDEN, A. T., FEDERICI, A. B., NURDEN, P.

“…Type 2B von Willebrand disease (VWD2B) is caused by gain‐of‐function amino acid substitutions in the von Willebrand factor (VWF) A1 domain. These allow…”
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Mutation analysis for a patient with Glanzmann thrombasthenia who produced a landmark isoantibody to the αIIbβ3 integrin by NURDEN, A. T., KUNICKI, T., NURDEN, P., FIORE, M., MARTINS, N., HEILIG, R., PILLOIS, X.

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Interesting variations on how a disease is defined: comparisons of von Willebrand disease and Glanzmann thrombasthenia by NURDEN, A. T.

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Polymorphisms and platelet genotyping: the shape of things to come by NURDEN, A. T.

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Platelet membrane glycoproteins: historical perspectives by NURDEN, A. T., PHILLIPS, D. R., GEORGE, J. N.

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Analysis of platelet membrane glycoprotein polymorphisms in Glanzmann thrombasthenia showed the French gypsy mutation in the αIIb gene to be strongly linked to the HPA‐1b polymorphism in β3 by Jacquelin, B., Tuleja, E., Kunicki, T. J., Nurden, P., Nurden, A. T.

“…We have tested the DNA of a large series of Glanzmann thrombasthenia patients for polymorphisms in platelet membrane glycoproteins. To our surprise, we noted a…”
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Triple heterozygosity in the integrin αIIbsubunit in a patient with Glanzmann's thrombasthenia by Nurden, A.T., Breillat, C., Jacquelin, B., Combrié, R., Freedman, J., Blanchette, V.S., Schmugge, M., Rand, M.L.

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