Search Results - "Nurden, A."

Advances in our understanding of the molecular basis of disorders of platelet function by NURDEN, A., NURDEN, P.

“…Genetic defects of platelet function give rise to mucocutaneous bleeding of varying severity because platelets fail to fulfil their haemostatic role after…”
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Inherited disorders of platelet function: selected updates by Nurden, A. T., Nurden, P.

“…Summary The gene variants responsible for the primary genotype of many platelet disorders have now been identified. Next‐generation sequencing technology…”
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Inherited platelet disorders by NURDEN, A. T., FRESON, K., SELIGSOHN, U.

“…Inherited diseases of the megakaryocyte lineage give rise to bleeding when platelets fail to fulfill their hemostatic function upon vessel injury. Platelet…”
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Professor Gustav Victor Rudolph Born (29 July 1921 – 16 April 2018) by Nurden, A. T.

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Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey by Gresele, P., Harrison, P., Bury, L., Falcinelli, E., Gachet, C., Hayward, C. P., Kenny, D., Mezzano, D., Mumford, A. D., Nugent, D., Nurden, A. T., Orsini, S., Cattaneo, M.

“…Summary Background Diagnosis of inherited platelet function disorders (IPFDs) is important for appropriate management and to improve epidemiologic and clinical…”
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Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients by Anitua, E., Sánchez, M., Nurden, A. T., Zalduendo, M. M., de la Fuente, M., Azofra, J., Andía, I.

“…Objectives. Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. Our…”
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Qualitative disorders of platelets and megakaryocytes by NURDEN, A. T.

“…Qualitative disorders of platelet function and production form a large group of rare diseases which cover a multitude of genetic defects that by and large have…”
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Peripartum bleeding management in a patient with CalDAG‐GEFI deficiency by Canault, M., Saultier, P., Fauré, S., Poggi, M., Nurden, A. T, Nurden, P., Morange, P. E., Alessi, M‐C., Gris, J‐C.

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An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families by Matus, V., Valenzuela, G., Sáez, C. G., Hidalgo, P., Lagos, M., Aranda, E., Panes, O., Pereira, J., Pillois, X., Nurden, A. T., Mezzano, D.

“…Summary Background Glycoprotein VI (GPVI), 60–65 kDa, is a major collagen receptor on platelet membranes involved in adhesive and signaling responses. Mice…”
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Inherited disorders of platelet function: selected updates by Nurden, A.T., Nurden, P.

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The abnormal proplatelet formation in MYH9‐related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition by Chen, Y., Boukour, S., Milloud, R., Favier, R., Saposnik, B., Schlegel, N., Nurden, A., Raslova, H., Vainchenker, W., Balland, M., Nurden, P., Debili, N.

“…Summary Background Mutations in the MYH9 gene cause autosomal dominant MYH9‐related diseases (MYH9‐RD) that associate macrothrombocytopenia with various other…”
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Natural history of platelet antibody formation against αIIbβ3 in a French cohort of Glanzmann thrombasthenia patients by FIORE, M., FIRAH, N., PILLOIS, X., NURDEN, P., HEILIG, R., NURDEN, A. T.

“…Treatment of the bleeding syndrome in Glanzmann thrombasthenia (GT) is often complicated by naturally occurring isoantibodies directed against the αIIbβ3…”
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Glanzmann thrombasthenia: the need for epidemiological studies by NURDEN, A. T.

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Does ATP act through P2X(1) receptors to regulate platelet activation and thrombus formation? by Nurden, A T

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An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis by NURDEN, P., TANDON, N., TAKIZAWA, H., COUZI, L., MOREL, D., FIORE, M., PILLOIS, X., LOYAU, S., JANDROT‐PERRUS, M., NURDEN, A. T.

“…Background: GPVI is a major platelet collagen signaling receptor. In rare cases of immune thrombocytopenic purpura (ITP), autoantibodies to GPVI result in…”
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European Working Group on Clinical Cell Analysis: Consensus protocol for the flow cytometric characterisation of platelet function by Schmitz, G, Rothe, G, Ruf, A, Barlage, S, Tschöpe, D, Clemetson, K J, Goodall, A H, Michelson, A D, Nurden, A T, Shankey, T V

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Use of autologous platelet-rich clots for the prevention of local injury bleeding in patients with severe inherited mucocutaneous bleeding disorders by NURDEN, P., YOULOUZ-MARFAK, I., SIBERCHICOT, F., KOSTRZEWA, E., ANDIA, I., ANITUA, E., NURDEN, A. T.

“…Stopping or preventing local bleeding in patients with inherited bleeding disorders linked to abnormal platelet function is traditionally treated by…”
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Altered megakaryocytopoiesis in von Willebrand type 2B disease by NURDEN, A. T., FEDERICI, A. B., NURDEN, P.

“…Type 2B von Willebrand disease (VWD2B) is caused by gain‐of‐function amino acid substitutions in the von Willebrand factor (VWF) A1 domain. These allow…”
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Mutation analysis for a patient with Glanzmann thrombasthenia who produced a landmark isoantibody to the αIIbβ3 integrin by NURDEN, A. T., KUNICKI, T., NURDEN, P., FIORE, M., MARTINS, N., HEILIG, R., PILLOIS, X.

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Polymorphisms of human platelet membrane glycoproteins: structure and clinical significance by Nurden, A T

“…The haemostatic response of platelets of any one individual will be influenced by the genetic profile of the total population of receptors expressed on the…”
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