Search Results - "Nurcombe, Victor"

Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine by Samsonraj, Rebekah M., Raghunath, Michael, Nurcombe, Victor, Hui, James H., van Wijnen, Andre J., Cool, Simon M.

“…Mesenchymal stem cells (MSC) hold great potential for regenerative medicine because of their ability for self‐renewal and differentiation into tissue‐specific…”
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Establishing Criteria for Human Mesenchymal Stem Cell Potency by Samsonraj, Rebekah M., Rai, Bina, Sathiyanathan, Padmapriya, Puan, Kia Joo, Rötzschke, Olaf, Hui, James H., Raghunath, Michael, Stanton, Lawrence W., Nurcombe, Victor, Cool, Simon M.

“…This study sought to identify critical determinants of mesenchymal stem cell (MSC) potency using in vitro and in vivo attributes of cells isolated from the…”
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The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19? by Hondermarck, Hubert, Bartlett, Nathan W., Nurcombe, Victor

“…Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to…”
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Vascular Endothelial Growth Factor 165-Binding Heparan Sulfate Promotes Functional Recovery From Cerebral Ischemia by Chan, Su Jing, Esposito, Elga, Hayakawa, Kazuhide, Mandaville, Emiri, Smith, Raymond A.A., Guo, Shuzhen, Niu, Wanting, Wong, Peter Tsun-Hong, Cool, Simon M., Lo, Eng H., Nurcombe, Victor

“…BACKGROUND AND PURPOSE:Although VEGF165 (vascular endothelial growth factor-165) is able to enhance both angiogenesis and neurogenesis, it also increases…”
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The Components of Bone and What They Can Teach Us about Regeneration by Le, Bach Quang, Nurcombe, Victor, Cool, Simon McKenzie, van Blitterswijk, Clemens A, de Boer, Jan, LaPointe, Vanessa Lydia Simone

“…The problem of bone regeneration has engaged both physicians and scientists since the beginning of medicine. Not only can bone heal itself following most…”
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Controlled release of heparin from poly( ε-caprolactone) electrospun fibers by Luong-Van, Emma, Grøndahl, Lisbeth, Chua, Kian Ngiap, Leong, Kam W., Nurcombe, Victor, Cool, Simon M.

“…Sustained delivery of heparin to the localized adventitial surface of grafted blood vessels has been shown to prevent the vascular smooth muscle cell (VSMC)…”
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Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer by ADRIAENSSENS, Eric, VANHECKE, Elsa, SAULE, Pasquine, MOUGEL, Alexandra, PAGE, Adeline, ROMON, Rodrigue, NURCOMBE, Victor, LE BOURHIS, Xuefen, HONDERMARCK, Hubert

“…We show here that nerve growth factor (NGF), the prototypic neurotrophin, can be targeted in breast cancer to inhibit tumor cell proliferation, survival, and…”
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The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation by Bhakta, Gajadhar, Lim, Zophia X.H., Rai, Bina, Lin, Tingxuan, Hui, James H., Prestwich, Glenn D., van Wijnen, Andre J., Nurcombe, Victor, Cool, Simon M.

“…Bone morphogenetic protein-2 (BMP-2) is known to enhance fracture healing when delivered via a bovine collagen sponge. However, collagen rapidly releases BMP-2…”
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Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2) by Bramono, Diah S, Murali, Sadasivam, Rai, Bina, Ling, Ling, Poh, Wei Theng, Lim, Zophia Xuehui, Stein, Gary S, Nurcombe, Victor, van Wijnen, Andre J, Cool, Simon M

“…Abstract Lowering the efficacious dose of bone morphogenetic protein-2 (BMP-2) for the repair of critical-sized bone defects is highly desirable, as…”
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Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells by Ling, Ling, Camilleri, Emily T., Helledie, Torben, Samsonraj, Rebekah M., Titmarsh, Drew M., Chua, Ren Jie, Dreesen, Oliver, Dombrowski, Christian, Rider, David A., Galindo, Mario, Lee, Ian, Hong, Wanjin, Hui, James H., Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.

“…Chronic use of heparin as an anti-coagulant for the treatment of thrombosis or embolism invokes many adverse systemic events including thrombocytopenia,…”
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Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function by Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Nurcombe, Victor, Cool, Simon M

“…Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously…”
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Growth Differentiation Factor 5-Mediated Enhancement of Chondrocyte Phenotype Is Inhibited by Heparin: Implications for the Use of Heparin in the Clinic and in Tissue Engineering Applications by Ayerst, Bethanie I, Smith, Raymond A A, Nurcombe, Victor, Day, Anthony J, Merry, Catherine L R, Cool, Simon M

“…The highly sulfated glycosaminoglycan (GAG) heparin is widely used in the clinic as an anticoagulant, and researchers are now using it to enhance stem cell…”
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Autocrine Fibroblast Growth Factor 2 Increases the Multipotentiality of Human Adipose‐Derived Mesenchymal Stem Cells by Rider, David A., Dombrowski, Christian, Sawyer, Amber A., Ng, Grace H. B., Leong, David, Hutmacher, Dietmar W., Nurcombe, Victor, Cool, Simon M.

“…Multipotent mesenchymal stem cells (MSCs), first identified in the bone marrow, have subsequently been found in many other tissues, including fat, cartilage,…”
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Multifunctional silica nanoparticles with potentials of imaging and gene delivery by Bhakta, Gajadhar, PhD, Sharma, Rakesh Kumar, PhD, Gupta, Nikesh, MSc, Cool, Simon, PhD, Nurcombe, Victor, PhD, Maitra, Amarnath, PhD, FNA

“…Abstract This article reports the method of preparation of gadolinium oxide-doped silica nanoparticles (NPs) whose surface has been functionalized to anchor…”
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Disruption of Heparan and Chondroitin Sulfate Signaling Enhances Mesenchymal Stem Cell‐Derived Osteogenic Differentiation via Bone Morphogenetic Protein Signaling Pathways by Manton, Kerry J., Leong, Denise F. M., Cool, Simon M., Nurcombe, Victor

“…Cell surface heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans have been implicated in a multitude of biological processes, including embryonic…”
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Microfluidic Screening Reveals Heparan Sulfate Enhances Human Mesenchymal Stem Cell Growth by Modulating Fibroblast Growth Factor‐2 Transport by Titmarsh, Drew M., Tan, Clarissa L.L., Glass, Nick R., Nurcombe, Victor, Cooper‐White, Justin J., Cool, Simon M.

“…Cost‐effective expansion of human mesenchymal stem/stromal cells (hMSCs) remains a key challenge for their widespread clinical deployment. Fibroblast growth…”
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Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans by Ling, Ling, Ren, Xiafei, Cao, Xue, Hassan, Afizah Binte Mohd, Mah, Sophia, Sathiyanathan, Padmapriya, Smith, Raymond A.A., Tan, Clarissa L.L., Eio, Michelle, Samsonraj, Rebekah M., van Wijnen, Andre J., Raghunath, Michael, Nurcombe, Victor, Hui, James H., Cool, Simon M.

“…Human mesenchymal stem cell (hMSC) therapy offers significant potential for osteochondral regeneration. Such applications require their ex vivo expansion in…”
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Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells by Dombrowski, Christian, Song, Shu Jun, Chuan, Peiying, Lim, Xinhong, Susanto, Evelyn, Sawyer, Amber A, Woodruff, Maria A, Hutmacher, Dietmar W, Nurcombe, Victor, Cool, Simon M

“…The growth and differentiation of mesenchymal stem cells (MSCs) is controlled by various growth factors, the activities of which can be modulated by heparan…”
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The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis by Haupt, Larisa M., Murali, Sadasivam, Mun, Foong Kin, Teplyuk, Nadiya, Mei, Leong Fong, Stein, Gary S., van Wijnen, Andre J., Nurcombe, Victor, Cool, Simon M.

“…Heparan sulfate (HS) sugar chains attached to core proteoglycans (PGs) termed HSPGs mediate an extensive range of cell–extracellular matrix (ECM) and growth…”
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Heparan sulfate enhances the self-renewal and therapeutic potential of mesenchymal stem cells from human adult bone marrow by Helledie, Torben, Dombrowski, Christian, Rai, Bina, Lim, Zophia X H, Hin, Ian Lee Hock, Rider, David A, Stein, Gary S, Hong, Wanjin, van Wijnen, Andre J, Hui, James H, Nurcombe, Victor, Cool, Simon M

“…Insufficient cell number hampers therapies utilizing adult human mesenchymal stem cells (hMSCs) and current ex vivo expansion strategies lead to a loss of…”
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