Search Results - "Nuno Leal"

Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective by Wilson, Emma L., Yu, Yizhou, Leal, Nuno S., Woodward, James A., Patikas, Nikolaos, Morris, Jordan L., Field, Sarah F., Plumbly, William, Paupe, Vincent, Chowdhury, Suvagata R., Antrobus, Robin, Lindop, Georgina E., Adia, Yusuf M., Loh, Samantha H. Y., Prudent, Julien, Martins, L. Miguel, Metzakopian, Emmanouil

“…Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact…”
Get full text

Um Precipitante Inesperado para a Descompensação da Diabetes Mellitus by Silva, Luciana, P. Silva, Leonor, Leal, Nuno, Cochicho, Joana

Get full text

Ecthyma gangrenosum: A view of blood on the skin by Murteira, Fábio, Leal, Nuno, Silva, Carina

“…Cutaneous findings should be actively sought in suspected cases of sepsis, as some of them (such as ecthyma gangrenosum) may provide clues about the infectious…”
Get full text

Use of a Boari flap and renal descensus as treatment for proximal ureteral rupture in a cat by Gordo, Inês, Mestrinho, Lisa A, Minderico, Maria M, Leal, Nuno M, Hamaide, Annick J

“…CASE DESCRIPTION A 6-year-old neutered male domestic shorthair cat was evaluated because of signs of abdominal pain and anuria of 12 hours' duration after…”
Get full text

Mitofusin‐2 knockdown increases ER–mitochondria contact and decreases amyloid β‐peptide production by Leal, Nuno Santos, Schreiner, Bernadette, Pinho, Catarina Moreira, Filadi, Riccardo, Wiehager, Birgitta, Karlström, Helena, Pizzo, Paola, Ankarcrona, Maria

“…Mitochondria are physically and biochemically in contact with other organelles including the endoplasmic reticulum (ER). Such contacts are formed between…”
Get full text

Mind the Gap: Mitochondria and the Endoplasmic Reticulum in Neurodegenerative Diseases by Leal, Nuno Santos, Martins, Luís Miguel

“…The way organelles are viewed by cell biologists is quickly changing. For many years, these cellular entities were thought to be unique and singular structures…”
Get full text

Alzheimer's and Parkinson's Diseases Predict Different COVID-19 Outcomes: A UK Biobank Study by Yu, Yizhou, Travaglio, Marco, Popovic, Rebeka, Leal, Nuno Santos, Martins, Luis Miguel

“…In December 2019, a coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began infecting humans, causing a novel disease, coronavirus…”
Get full text

Micro-PIV and CFD characterization of flows in a microchannel: Velocity profiles, surface roughness and Poiseuille numbers by Silva, Gonçalo, Leal, Nuno, Semiao, Viriato

“…Microfluidics is a promising technology, although the governing physical mechanisms are still not quite understood due to the difficulties arising in measuring…”
Get full text

Mortars from the Palace of Knossos in Crete, Greece: A Multi-Analytical Approach by Fernanda Carvalho, Pedro Sousa, Nuno Leal, Joaquim Simão, Elissavet Kavoulaki, Maria Margarida Lima, Teresa Pereira da Silva, Hugo Águas, Giuseppina Padeletti, João Pedro Veiga

“…The study of building materials constituting cultural heritage is fundamental to understand their characteristics and predict their behavior. When considering…”
Get full text

Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study by Dantas, Diana, Soares, Liliana, Novais, Susana, Vilarinho, Rui, Moreira, J. Agostinho, Silva, Susana, Frazao, Orlando, Oliveira, Teresa, Leal, Nuno, Faisca, Pedro, Reis, Joana

“…Breast cancer is a health problem that affects individual life quality and the family system. It is the most frequent type of cancer in women, but men are also…”
Get full text

Mitochondrial Alterations in Neurons Derived from the Murine AppNL-F Knock-In Model of Alzheimer's Disease by Dentoni, Giacomo, Naia, Luana, Portal, Benjamin, Leal, Nuno Santos, Nilsson, Per, Lindskog, Maria, Ankarcrona, Maria

“…Alzheimer's disease (AD) research has relied on mouse models overexpressing human mutant A βPP; however, newer generation knock-in models allow for…”
Get more information

Retrospective Study of 18 Titanium Alloy Crowns Produced by Computer-Aided Design and Manufacturing in Dogs by Mestrinho, Lisa A, Gordo, Inês, Gawor, Jerzy, Leal, Nuno, Niza, Maria

“…Computer-aided design (CAD) and computer-aided manufacturing (CAM) technology is routinely used in various fields of human dentistry, particularly…”
Get full text

Pre-Multidrug-Resistant Mycobacterium tuberculosis Beijing Strain Associated with Disseminated Tuberculosis in a Pet Dog by Botelho, Ana, Perdigão, João, Canto, Ana, Albuquerque, Teresa, Leal, Nuno, Macedo, Rita, Portugal, Isabel, Cunha, Mónica V

“…Classifications Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Foliar Spraying of Solanum tuberosum L. with CaCl2 and Ca(NO3)2: Interactions with Nutrients Accumulation in Tubers by Coelho, Ana Rita F., Ramalho, José Cochicho, Lidon, Fernando Cebola, Marques, Ana Coelho, Daccak, Diana, Pessoa, Cláudia Campos, Luís, Inês Carmo, Guerra, Mauro, Leitão, Roberta G., Semedo, José Manuel N., Silva, Maria Manuela, Pais, Isabel P., Leal, Nuno, Galhano, Carlos, Rodrigues, Ana Paula, Legoinha, Paulo, Silva, Maria José, Simões, Maria, Scotti Campos, Paula, Pessoa, Maria Fernanda, Reboredo, Fernando Henrique

“…Calcium is essential for plants, yet as its mobility is limited, the understanding of the rate of Ca2+ accumulation and deposition in tissues of tubers, as…”
Get full text

Enhancing mitochondrial one-carbon metabolism is neuroprotective in Alzheimer’s disease models by Yu, Yizhou, Chen, Civia Z., Celardo, Ivana, Tan, Bryan Wei Zhi, Hurcomb, James D., Leal, Nuno Santos, Popovic, Rebeka, Loh, Samantha H. Y., Martins, L. Miguel

“…Alzheimer’s disease (AD) is the most common form of age-related dementia. In AD, the death of neurons in the central nervous system is associated with the…”
Get full text

Nilotinib and imatinib are comparably effective in reducing growth of human eosinophil leukemia cells in a newly established xenograft model by Wicklein, Daniel, Ramos Leal, Nuno, Salamon, Johannes, Thamer, Mohammed, Herrmann, Harald, Valent, Peter, Schumacher, Udo, Ullrich, Sebastian

“…We developed a xenograft model of human Chronic Eosinophilic Leukemia (CEL) to study disease progression and remission-induction under therapy with tyrosine…”
Get full text

Magnesium Accumulation in Two Contrasting Varieties of Lycopersicum esculentum L. Fruits: Interaction with Calcium at Tissue Level and Implications on Quality by Pessoa, Cláudia Campos, Lidon, Fernando C., Coelho, Ana Rita F., Marques, Ana Coelho, Daccak, Diana, Luís, Inês Carmo, Caleiro, João Cravidão, Kullberg, José Carlos, Legoinha, Paulo, Brito, Maria Graça, Ramalho, José Cochicho, Silva, Maria José, Rodrigues, Ana Paula, Guerra, Mauro, Leitão, Roberta G., Campos, Paula Scotti, Pais, Isabel P., Semedo, José N., Silva, Maria Manuela, Galhano, Carlos, Leal, Nuno, Reboredo, Fernando H., Pessoa, Maria Fernanda, Simões, Manuela

“…As the productivity and quality of tomato fruits are responsive to Mg applications, without surpassing the threshold of toxicity, the assessment of potential…”
Get full text

Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson’s disease by Popovic, Rebeka, Mukherjee, Amrita, Leal, Nuno Santos, Morris, Lydia, Yu, Yizhou, Loh, Samantha H. Y., Miguel Martins, L.

“…Parkinson’s disease (PD) is characterised by selective death of dopaminergic (DA) neurons in the midbrain and motor function impairment. Gastrointestinal…”
Get full text

Upregulation of Tribbles decreases body weight and increases sleep duration by Popovic, Rebeka, Yu, Yizhou, Leal, Nuno Santos, Fedele, Giorgio, Loh, Samantha H Y, Martins, L Miguel

“…Eukaryotic Tribbles proteins are pseudoenzymes that regulate multiple aspects of intracellular signalling. Both Drosophila melanogaster and mammalian members…”
Get full text

Amyloid Β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer's Disease-Related Models by Leal, Nuno Santos, Dentoni, Giacomo, Schreiner, Bernadette, Naia, Luana, Piras, Antonio, Graff, Caroline, Cattaneo, Antonio, Meli, Giovanni, Hamasaki, Maho, Nilsson, Per, Ankarcrona, Maria

“…Recent findings have shown that the connectivity and crosstalk between mitochondria and the endoplasmic reticulum (ER) at mitochondria-ER contact sites (MERCS)…”
Get full text