Search Results - "Nuno, Daniel W"

Dietary Fatty Acid Saturation Modulates Sphingosine-1-Phosphate-Mediated Vascular Function by Nuno, Daniel W., Lamping, Kathryn G.

“…Sphingolipids, modified by dietary fatty acids, are integral components of plasma membrane and caveolae that are also vasoactive compounds. We hypothesized…”
Get full text

Sex-dependent differences in Rho activation contribute to contractile dysfunction in type 2 diabetic mice by Nuno, Daniel W, Harrod, Jeremy S, Lamping, Kathryn G

“…The objective of this study was to determine if mechanisms involved in vascular dysfunction in type 2 diabetes differ with sex. Vascular reactivity,…”
Get more information

Dietary fats modify vascular fat composition, eNOS localization within lipid rafts and vascular function in obesity by Nuno, Daniel W., Coppey, Lawrence J., Yorek, Mark A., Lamping, Kathryn G.

“…We tested whether dietary fatty acids alter membrane composition shifting localization of signaling pathways within caveolae to determine their role in…”
Get full text

RhoA Activation Contributes to Sex Differences in Vascular Contractions by Nuno, Daniel W, Korovkina, Victoria P, England, Sarah K, Lamping, Kathryn G

“…OBJECTIVE—Studies have suggested that sex differences in endothelial function in part account for the lower incidence of cardiovascular disease in…”
Get full text

Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice by Lamping, K G, Nuno, D W, Shesely, E G, Maeda, N, Faraci, F M

“…Previous studies have demonstrated that responses to endothelium-dependent vasodilators are absent in the aortas from mice deficient in expression of…”
Get more information

RhoA localization with caveolin-1 regulates vascular contractions to serotonin by Nuno, Daniel W, England, Sarah K, Lamping, Kathryn G

“…Vascular smooth muscle contraction occurs following an initial response to an increase in intracellular calcium concentration and a sustained response…”
Get more information

Differential Control of Calcium Homeostasis and Vascular Reactivity by Ca2+/Calmodulin-Dependent Kinase II by Prasad, Anand M, Nuno, Daniel W, Koval, Olha M, Ketsawatsomkron, Pimonrat, Li, Weiwei, Li, Hui, Shen, Fred Y, Joiner, Mei-ling A, Kutschke, William, Weiss, Robert M, Sigmund, Curt D, Anderson, Mark E, Lamping, Kathryn G, Grumbach, Isabella M

“…The multifunctional Ca/calmodulin-dependent kinase II (CaMKII) is activated by vasoconstrictors in vascular smooth muscle cells (VSMC), but its impact on…”
Get full text

Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function by Prasad, Anand M, Morgan, Donald A, Nuno, Daniel W, Ketsawatsomkron, Pimonrat, Bair, Thomas B, Venema, Ashlee N, Dibbern, Megan E, Kutschke, William J, Weiss, Robert M, Lamping, Kathryn G, Chapleau, Mark W, Sigmund, Curt D, Rahmouni, Kamal, Grumbach, Isabella M

“…Multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by angiotensin II (Ang II) in cultured vascular smooth muscle cells (VSMCs), but…”
Get full text

Role of CaMKII in Ang-II-dependent small artery remodeling by Prasad, Anand M, Ketsawatsomkron, Pimonrat, Nuno, Daniel W, Koval, Olha M, Dibbern, Megan E, Venema, Ashlee N, Sigmund, Curt D, Lamping, Kathryn G, Grumbach, Isabella M

“…Abstract Angiotensin-II (Ang-II) is a well-established mediator of vascular remodeling. The multifunctional calcium-calmodulin-dependent kinase II (CaMKII) is…”
Get full text

Overexpression of the SK3 channel alters vascular remodeling during pregnancy, leading to fetal demise by Rada, Cara C, Pierce, Stephanie L, Nuno, Daniel W, Zimmerman, Kathy, Lamping, Kathryn G, Bowdler, Noelle C, Weiss, Robert M, England, Sarah K

“…The maternal cardiovascular system undergoes hemodynamic changes during pregnancy via angiogenesis and vasodilation to ensure adequate perfusion of the…”
Get more information

Muscarinic (M) Receptors in Coronary Circulation Gene-Targeted Mice Define the Role of M2 and M3 Receptors in Response to Acetylcholine by Lamping, Kathryn G, Wess, Jürgen, Cui, Yinghong, Nuno, Daniel W, Faraci, Frank M

“…OBJECTIVE—Determining the role of specific muscarinic (M) receptor subtypes mediating responses to acetylcholine (ACh) has been limited by the specificity of…”
Get full text

The Role of Rho Kinase in Sex-Dependent Vascular Dysfunction in Type 1 Diabetes by Nuno, Daniel W., Lamping, Kathryn G.

“…We hypothesized that rho/rho kinase plays a role in sex differences in vascular dysfunction of diabetics. Contractions to serotonin were greater in isolated…”
Get full text

Abstract 17415: Mitochondrial Ca2+/Calmodulin-Dependent Kinase II Inhibition Changes the Calcium Homeostasis in the Endothelium and Decreases the Vascular Relaxation in Mesenteric Arteries by Damacena De Angelis, Celio, Nuno, Daniel W, Koval, Olha, Lamping, Kathryn G, Grumbach, Isabella M

“…IntroductionThe Ca2+/Calmodulin-dependent Kinase II (CaMKII) is present in mitochondria and cytosol. In mitochondria, it regulates the mitochondrial Ca2+…”
Get full text

Agonist-specific impairment of coronary vascular function in genetically altered, hyperlipidemic mice by Lamping, K.G. (The Cardiovascular Center, Iowa City, IA.), Nuno, D.W, Chappell, D.A, Faraci, F.M

“…The objectives of the present study were to 1) examine mechanisms involved in endothelium-dependent responses of coronary arteries from normal mice and 2)…”
Get full text

Abnormal Coronary Function in Mice Deficient in α₁H T-type Ca2⁺ Channels by Chen, Chien-Chang, Lamping, Kathryn G., Nuno, Daniel W., Barresi, Rita, Prouty, Sally J., Lavoie, Julie L., Cribbs, Leanne L., England, Sarah K., Sigmund, Curt D., Weiss, Robert M., Williamson, Roger A., Hill, Joseph A., Campbell, Kevin P.

“…Calcium ion (Ca2+) influx through voltage-gated Ca2+channels is important for the regulation of vascular tone. Activation of L-type Ca2+channels initiates…”
Get full text

Deficiency in caveolin‐1 or type 2 diabetes augments vasoconstrictor responses to sphingosine‐1‐phosphate by Lamping, Kathryn G, Nelson, Peter M, Nuno, Daniel W

“…Abstract only Sphingolipids are not only integral membrane components but also vasoactive signaling molecules. We tested the hypothesis that vascular responses…”
Get full text

Effect of acute hypertension in the coronary circulation: role of mechanical factors and oxygen radicals by De Bruyn, V H, Nuno, D W, Cappelli-Bigazzi, M, Dole, W P, Lamping, K G

“…In previous studies severe, acute hypertension damaged the endothelium in proximal coronary arteries and selectively potentiated constriction of the artery to…”
Get more information

Serotonin‐induced vascular contractions are regulated by rhoA localization within caveolar microdomains by Lamping, Kathryn G, England, Sarah K, Nuno, Daniel W

“…RhoA is compartmentalized within caveolae in vascular tissue to regulate activation. We hypothesized that in the absence of caveolin‐1 (cav‐1), a requirement…”
Get full text

Chronic inhibition of rho‐kinase augments contractions in diabetes by Lamping, Kathryn Griffin, Nuno, Daniel W.

“…Abstract only Objective: Acute inhibition of rho‐kinase decreases augmented contractions of arteries in diabetic animals. The objective of this study was to…”
Get full text

The role of NO and rho kinase in contractions to serotonin in diabetic mice by Lamping, Kathy G, Harrod, Jeremy, Nuno, Daniel W

“…Abstract only Contraction to serotonin (5HT) is increased and relaxation to acetylcholine (ACH) is reduced in arteries from leptin receptor diabetic mice (DB)…”
Get full text