Search Results - "Nunez, Derek J.R."

Exploring glycosuria as a mechanism for weight and fat mass reduction. A pilot study with remogliflozin etabonate and sergliflozin etabonate in healthy obese subjects by Napolitano, Antonella, Miller, Sam, Murgatroyd, Peter R, Hussey, Elizabeth, Dobbins, Robert L, Bullmore, Edward T, Nunez, Derek J.R

“…Abstract Inhibitors of sodium-dependent glucose co-transporter 2 (SGLT2) increase glucose excretion in the urine and improve blood glucose in Type 2 diabetes…”
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Quantitative Magnetic Resonance (QMR) for Longitudinal Evaluation of Body Composition Changes With Two Dietary Regimens by Myint, Khin Swe, Napolitano, Antonella, Miller, Sam R, Murgatroyd, Peter R, Elkhawad, Maysoon, Nunez, Derek J.R, Finer, Nick

“…We have recently reported a validation study of a prototype low-field strength quantitative magnetic resonance (QMR) instrument for measurement of human body…”
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c-fos may code for a common transcription factor within the hypothalamic neural circuits involved in osmoregulation by Hamamura, M, Nunez, D J, Leng, G, Emson, P C, Kiyama, H

“…Conscious rats were given an intraperitoneal (i.p.) injection of isotonic or hypertonic saline, and killed 10-240 min later. In the hypothalamus of hypertonic…”
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Single-Dose Pharmacokinetics and Pharmacodynamics of Sergliflozin Etabonate, a Novel Inhibitor of Glucose Reabsorption, in Healthy Volunteers and Patients With Type 2 Diabetes Mellitus by Hussey, Elizabeth K., Clark, Richard V., Amin, Dipti M., Kipnes, Mark S., O'Connor-Semmes, Robin L., O'Driscoll, Eilis C., Leong, Jenny, Murray, Sharon C., Dobbins, Robert L., Layko, Debbi, Nunez, Derek J. R.

“…Sergliflozin, the active entity of sergliflozin etabonate, is a selective inhibitor of sodium‐dependent glucose cotransporter 2 (SGLT2). The pharmacokinetics…”
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Multiple-Dose Pharmacokinetics and Pharmacodynamics of Sergliflozin Etabonate, a Novel Inhibitor of Glucose Reabsorption, in Healthy Overweight and Obese Subjects: A Randomized Double-Blind Study by Hussey, Elizabeth K., Dobbins, Robert L., Stoltz, Randall R., Stockman, Nancy L., O'Connor-Semmes, Robin L., Kapur, Anita, Murray, Sharon C., Layko, Debbi, Nunez, Derek J. R.

“…Sergliflozin, the active entity of sergliflozin etabonate, is a selective inhibitor of the sodium‐dependent glucose cotransporter‐2 in the renal tubule. The…”
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Reduced T2 values in soleus muscle of patients with type 2 diabetes mellitus by Zuo, Chun S, Sung, Young-Hoon, Simonson, Donald C, Habecker, Erin, Wang, Jian, Haws, Charlotte, Villafuerte, Rosemond A, Henry, Michael E, Dobbins, Robert L, Hodge, Rebecca J, Nunez, Derek J R, Renshaw, Perry F

“…Tissue water transverse relaxation times (T2) are highly sensitive to fluid and lipid accumulations in skeletal muscles whereas the related T2* is sensitive to…”
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Echocardiographic characterization of cardiomyopathy in Friedreich's ataxia with tissue Doppler echocardiographically derived myocardial velocity gradients by DUTKA, David P, DONNELLY, J. Elisabeth, PALKA, Przemyslaw, LANGE, Aleksandra, NUNEZ, Derek J. R, NIHOYANNOPOULOS, Petros

“…Conventional and tissue Doppler echocardiographically derived myocardial velocity gradients (MVGs) were used to characterize the myocardium in patients with…”
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Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine by Murgatroyd, Peter R., Hussey, Elizabeth K., Napolitano, Antonella, Nunez, Derek J. R., O'Rahilly, Steve, Dobbins, Robert, Finer, Nick

“…Evidence of active brown adipose tissue in human adults suggests that this may become a pharmacological target to induce negative energy balance. We have…”
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alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways by Wernicke, Dirk, Thiel, Corinna, Duja-Isac, Corina M, Essin, Kirill V, Spindler, Matthias, Nunez, Derek J R, Plehm, Ralph, Wessel, Niels, Hammes, Annette, Edwards, Robert-J, Lippoldt, Andrea, Zacharias, Ute, Strömer, Hinrik, Neubauer, Stefan, Davies, Michael J, Morano, Ingo, Thierfelder, Ludwig

“…To study the mechanisms by which missense mutations in alpha-tropomyosin cause familial hypertrophic cardiomyopathy, we generated transgenic rats…”
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Regional hemodynamic effects of the N-(2-benzoylphenyl)-L-tyrosine peroxisome proliferator-activated receptor-gamma ligand, GI 262570 [(S)-2-(2-benzoylphenylamino)-3-[4-[2-(5-methyl-2-phenyl-2-oxazol-4-yl)ethoxy]phenyl]propionic acid], in conscious rats by Gardiner, Sheila M, Nunez, Derek J R, Baer, Philip G, Brown, Kathleen K, Bennett, Terence

“…This study provides novel data on the regional hemodynamic effects of the peroxisome proliferator-activated receptor-gamma activator, GI 262570…”
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Natriuretic peptide receptor mRNAs in the rat and human heart by Nunez, D J, Dickson, M C, Brown, M J

“…Functional studies indicate that atrial natriuretic peptide (ANP), a member of the natriuretic peptide family, has direct effects on cardiac muscle cells…”
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Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17 : Evaluation of cardiac ryanodine Ryr2 receptor as a candidate by LAN ZHAO, SEBKHI, Abdelkrim, NUNEZ, Derek J. R, LU LONG, HALEY, Christopher S, SZPIRER, Josiane, SZPIRER, Claude, WILLIAMS, Alan J, WILKINS, Martin R

“…Fischer 344 (F344) rats are relatively resistant to hypoxia-induced right ventricular (RV) hypertrophy compared with the Wistar-Kyoto (WKY) strain. These 2…”
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Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat by BROWN, L. A, NUNEZ, D. J. R, WILKINS, M. R

“…The heart expresses the three natriuretic peptide receptors (NPR), namely NPR-A, NPR-B, and NPR-C. We have examined the temporal relationship between the…”
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Endothelin-1 mRNA is widely expressed in porcine and human tissues by NUMEZ, D. J. R, BROWN, M. J, DAVENPORT, A. P, NEYLON, C. B, SCHOFIELD, J. P, WYSE, R. K

“…Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. We have previously demonstrated widespread binding sites for…”
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Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung by Zhao, Lan, Al‐Tubuly, Rida, Sebkhi, Abdelkrim, Owji, Ali A., Nunez, Derek J.R., Wilkins, Martin R.

“…1 Angiotensin II (All) binding density and the effect of chronic All receptor blockade were examined in the rat model of hypoxia‐induced pulmonary…”
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Messenger RNAs encoding the natriuretic peptides and their receptors are expressed in the eye by Fernandez-Durango, Raquel, Nunez, Derek J.R., Brown, Morris J.

“…The rates of secretion and removal of aqueous humour are major determinants of intraocular pressure (IOP). The natriuretic peptides, atrial natriuretic peptide…”
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Adrenomedullin activity in chronically hypoxic rat lungs by Zhao, L, Brown, L A, Owji, A A, Nunez, D J, Smith, D M, Ghatei, M A, Bloom, S R, Wilkins, M R

“…Adrenomedullin (AM) is a novel vasodilator with structural similarities to calcitonin gene-related peptide (CGRP). This study investigated AM activity in the…”
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Hypertensive cardiac hypertrophy—is genetic variance the missing link? by NUNEZ, DEREK J. R., PIERS CLIFFORD, C., AL‐MAHDAWI, SAHAR, DUTKA, DAVID

“…1Hypertensive cardiac hypertrophy is a major independent predictor of adverse cardiovascular events. In man the cardiac response to increased afterload is very…”
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Downregulation of natriuretic peptide C-receptor protein in the hypertrophied ventricle of the aortovenocaval fistula rat by BROWN, L. A, RUTHERFORD, R. A. D, NUNEZ, D. J. R, WHARTON, J, LOWE, D. G, WILKINS, M. R

“…This study examined the expression of the C-type receptor for the natriuretic peptide family (NPR-C) in the ventricles of normal and aortovenocaval…”
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Genetic Determination of Cardiac Mass in Normotensive Rats: Results From an F344xWKY Cross by Sebkhi, Abdelkrim, Zhao, Lan, Lu, Long, Haley, Christopher S, Nunez, Derek J.R, Wilkins, Martin R

“…Genetic determinants affect adult cardiac mass and the predisposition to develop cardiac hypertrophy. The aim of this study was to identify quantitative trait…”
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