Combined exercise training improved exercise capacity and lung inflammation in rats with hepatopulmonary syndrome

Physical exercise training attenuates pulmonary inflammation, but its effects on impaired respiratory function caused by hepatopulmonary syndrome (HPS) have not been evaluated. We determined if the combination of moderate intensity aerobic and resistance training during HPS development modifies exer...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 287; p. 120112
Main Authors:	Nascimento, Eloisa Sanches Pereira, Nunes, Walter Moreno Campos, Guerra, Eduardo Marques, da Roza, Marcello Rodrigues, Silva-Costa, Suellen, Machado-Silva, Wilcelly, Avelar, Gleiciane Gontijo, de Toledo Nóbrega, Otávio, Vieira, Rodolfo P., Amado, Veronica Moreira, Melo-Silva, César Augusto
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 15-12-2021 Elsevier BV
Subjects:	Aerobic capacity Aerobic exercise Animals Epithelium Exercise Exercise Test - methods Exercise Tolerance - physiology Fitness training programs Hepatopulmonary syndrome Hepatopulmonary Syndrome - pathology Hepatopulmonary Syndrome - physiopathology Hepatopulmonary Syndrome - therapy Immunohistochemistry Inflammation Interleukin 10 Leukocytes Lungs Male Mechanics (physics) Physical Conditioning, Animal - methods Physical Conditioning, Animal - physiology Physical exercise Physical fitness Physical training Pneumonia - pathology Pneumonia - physiopathology Pneumonia - therapy Rats Rats, Wistar Resistance exercise Resistance training Respiratory function Respiratory mechanics Respiratory Mechanics - physiology Respiratory system Respiratory tract Training Respiratory mechanics Hepatopulmonary syndrome Resistance exercise Aerobic exercise
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Summary:	Physical exercise training attenuates pulmonary inflammation, but its effects on impaired respiratory function caused by hepatopulmonary syndrome (HPS) have not been evaluated. We determined if the combination of moderate intensity aerobic and resistance training during HPS development modifies exercise capacity, respiratory system mechanics, and lung inflammation responses. Wistar rats were randomly divided into sham, HPS, and HPS + combined exercise training groups. Fifteen days after HPS induction, a moderate intensity aerobic plus resistance exercise training protocol was performed five times a week for 5 weeks on alternate days. Exercise capacity, respiratory system mechanics, lung inflammation, pulmonary morphology, and immunohistochemistry were evaluated. Overall, our findings indicated that combined exercise training efficiently increased the maximal running and resistance capacity of HPS animals. The training regimen reduced the expression of P2X7 in parenchymal leukocytes (P < 0.01), partially restored the expression of interleukin-10 in airway epithelium (P < 0.01), and increased the expression of TFPI in the airway epithelium (P < 0.01) as well as reduced its expression in parenchymal leukocytes (P < 0.01). However, exercise training did not attenuate HPS-induced respiratory mechanical derangements or lung tissue remodeling. Combined exercise training can elicit adaptation with regard to both maximal running capacity and maximum strength and modify the expression of P2X7 and TFPI in parenchymal leukocytes and that of IL-10 in airway epithelium. •Combined exercise training increases exercise capacity in rats with hepatopulmonary syndrome.•Exercise training reduces the expression of P2X7 of parenchymal leukocytes in rats with hepatopulmonary syndrome.•Hepatopulmonary syndrome modifies lung morphology and mechanics.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2021.120112