Search Results - "Nunes, Paulo Sergio Gonçalves"

Medicinal (Radio) Chemistry: Building Radiopharmaceuticals for the Future by Pijeira, Martha Sahylí Ortega, Nunes, Paulo Sérgio Gonçalves, Chaviano, Samila Leon, Diaz, Aida M Abreu, DaSilva, Jean N, Ricci-Junior, Eduardo, Alencar, Luciana Magalhães Rebelo, Chen, Xiaoyuan, Santos-Oliveira, Ralph

“…Radiopharmaceuticals are increasingly playing a leading role in diagnosing, monitoring, and treating disease. In comparison with conventional pharmaceuticals,…”
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Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells by dos Santos, Daiane Fernanda, de Pilger, Denise Regina Bairros, Vandermeulen, Charlotte, Khouri, Ricardo, Mantoani, Susimaire Pedersoli, Nunes, Paulo Sérgio Gonçalves, de Andrade, Peterson, Carvalho, Ivone, Casseb, Jorge, Twizere, Jean-Claude, Willems, Luc, Freitas-Junior, Lucio, Kashima, Simone

“…[Display omitted] •1,2,3-triazole tethered fused heterocyclic ring derivatives have been synthesized.•8 compounds decreased the metabolic activity of…”
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Synthesis and Evaluation of [18F]FEtLos and [18F]AMBF3Los as Novel 18F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors by Sahylí Ortega Pijeira, Martha, Sérgio Gonçalves Nunes, Paulo, Nascimento dos Santos, Sofia, Zhang, Zhengxing, Pérez Nario, Arian, Araujo Perini, Efrain, Miguel Turato, Walter, Rodríguez Riera, Zalua, Chammas, Roger, H. Elsinga, Philip, Lin, Kuo-Shyan, Carvalho, Ivone, Soares Bernardes, Emerson

“…Losartan is widely used in clinics to treat cardiovascular related diseases by selectively blocking the angiotensin II type 1 receptors (AT1Rs), which regulate…”
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Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease by de Andrade, Peterson, Mantoani, Susimaire P., Gonçalves Nunes, Paulo Sérgio, Magadán, Carlos Roca, Pérez, Concepción, Xavier, Danilo Jordão, Hojo, Elza Tiemi Sakamoto, Campillo, Nuria E., Martínez, Ana, Carvalho, Ivone

“…[Display omitted] •Highly potent and selective hBuChE inhibitors have been successfully synthesized.•The proposed synthetic approach is efficient and…”
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Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole-quinazolines as antiproliferative agents displaying ERK inhibitory activity by Nunes, Paulo Sérgio Gonçalves, da Silva, Gabriel, Nascimento, Sofia, Mantoani, Susimaire Pedersoli, de Andrade, Peterson, Bernardes, Emerson Soares, Kawano, Daniel Fábio, Leopoldino, Andreia Machado, Carvalho, Ivone

“…[Display omitted] •Twelve ERK1/2 kinase inhibitors have been synthesized using CuAAC reaction.•Derivative 25a induced G0/G1 stalling in BT-20 cells and a…”
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Synthesis and evaluation of an 18F‐labeled trifluoroborate derivative of 2‐nitroimidazole for imaging tumor hypoxia with positron emission tomography by Nunes, Paulo Sérgio Gonçalves, Zhang, Zhengxing, Kuo, Hsiou‐Ting, Zhang, Chengcheng, Rousseau, Julie, Rousseau, Etienne, Lau, Joseph, Kwon, Daniel, Carvalho, Ivone, Bénard, François, Lin, Kuo‐Shyan

“…2‐Nitroimidazole‐based hypoxia imaging tracers such as 18F‐FMISO are normally imaged at late time points (several hours post‐injection) due to their slow…”
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Diastereoselective Synthesis of Highly Functionalized γ-Lactams via Ugi Reaction/Michael Addition by Correa, Arlene, Vidal, Herika Danielle Almeida, Januario, Marcelo Augusto Pereira, Martinez, Alice Karoline de Almeida, Nunes, Paulo Sergio Gonçalves, Santiago, Pedro Henrique de Oliveira, Ellena, Javier Alcides

“…The γ-lactam ring is a prominent feature in medicinal chemistry, and its synthesis has garnered significant interest due to its valuable properties. Among the…”
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Synthesis and evaluation of an 18 F-labeled trifluoroborate derivative of 2-nitroimidazole for imaging tumor hypoxia with positron emission tomography by Nunes, Paulo Sérgio Gonçalves, Zhang, Zhengxing, Kuo, Hsiou-Ting, Zhang, Chengcheng, Rousseau, Julie, Rousseau, Etienne, Lau, Joseph, Kwon, Daniel, Carvalho, Ivone, Bénard, François, Lin, Kuo-Shyan

“…2-Nitroimidazole-based hypoxia imaging tracers such as F-FMISO are normally imaged at late time points (several hours post-injection) due to their slow…”
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Synthesis and Evaluation of [ 18 F]FEtLos and [ 18 F]AMBF 3 Los as Novel 18 F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors by Sahylí Ortega Pijeira, Martha, Sérgio Gonçalves Nunes, Paulo, Nascimento Dos Santos, Sofia, Zhang, Zhengxing, Pérez Nario, Arian, Araujo Perini, Efrain, Miguel Turato, Walter, Rodríguez Riera, Zalua, Chammas, Roger, H Elsinga, Philip, Lin, Kuo-Shyan, Carvalho, Ivone, Soares Bernardes, Emerson

“…Losartan is widely used in clinics to treat cardiovascular related diseases by selectively blocking the angiotensin II type 1 receptors (AT Rs), which regulate…”
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