Search Results - "Nunes, Nuno M"

DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells by Chung, Jiil, Maruvka, Yosef E, Sudhaman, Sumedha, Kelly, Jacalyn, Haradhvala, Nicholas J, Bianchi, Vanessa, Edwards, Melissa, Forster, Victoria J, Nunes, Nuno M, Galati, Melissa A, Komosa, Martin, Deshmukh, Shriya, Cabric, Vanja, Davidson, Scott, Zatzman, Matthew, Light, Nicholas, Hayes, Reid, Brunga, Ledia, Anderson, Nathaniel D, Ho, Ben, Hodel, Karl P, Siddaway, Robert, Morrissy, A Sorana, Bowers, Daniel C, Larouche, Valérie, Bronsema, Annika, Osborn, Michael, Cole, Kristina A, Opocher, Enrico, Mason, Gary, Thomas, Gregory A, George, Ben, Ziegler, David S, Lindhorst, Scott, Vanan, Magimairajan, Yalon-Oren, Michal, Reddy, Alyssa T, Massimino, Maura, Tomboc, Patrick, Van Damme, An, Lossos, Alexander, Durno, Carol, Aronson, Melyssa, Morgenstern, Daniel A, Bouffet, Eric, Huang, Annie, Taylor, Michael D, Villani, Anita, Malkin, David, Hawkins, Cynthia E, Pursell, Zachary F, Shlien, Adam, Kunkel, Thomas A, Getz, Gad, Tabori, Uri

“…Although replication repair deficiency, either by mismatch repair deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in…”
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Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition by Campbell, Brittany B, Galati, Melissa A, Stone, Simone C, Riemenschneider, Alexandra N, Edwards, Melissa, Sudhaman, Sumedha, Siddaway, Robert, Komosa, Martin, Nunes, Nuno M, Nobre, Liana, Morrissy, A Sorana, Zatzman, Matthew, Zapotocky, Michal, Joksimovic, Lazar, Kalimuthu, Sangeetha N, Samuel, David, Mason, Gary, Bouffet, Eric, Morgenstern, Daniel A, Aronson, Melyssa, Durno, Carol, Malkin, David, Maris, John M, Taylor, Michael D, Shlien, Adam, Pugh, Trevor J, Ohashi, Pamela S, Hawkins, Cynthia E, Tabori, Uri

“…The RAS/MAPK pathway is an emerging targeted pathway across a spectrum of both adult and pediatric cancers. Typically, this is associated with a single,…”
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Cancers from Novel Pole -Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade by Galati, Melissa A, Hodel, Karl P, Gams, Miki S, Sudhaman, Sumedha, Bridge, Taylor, Zahurancik, Walter J, Ungerleider, Nathan A, Park, Vivian S, Ercan, Ayse B, Joksimovic, Lazar, Siddiqui, Iram, Siddaway, Robert, Edwards, Melissa, de Borja, Richard, Elshaer, Dana, Chung, Jiil, Forster, Victoria J, Nunes, Nuno M, Aronson, Melyssa, Wang, Xia, Ramdas, Jagadeesh, Seeley, Andrea, Sarosiek, Tomasz, Dunn, Gavin P, Byrd, Jonathan N, Mordechai, Oz, Durno, Carol, Martin, Alberto, Shlien, Adam, Bouffet, Eric, Suo, Zucai, Jackson, James G, Hawkins, Cynthia E, Guidos, Cynthia J, Pursell, Zachary F, Tabori, Uri

“…mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype-phenotype correlation, and therapeutic…”
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HGG-26. GENOMIC AND IMMUNE ANALYSIS OF PRIMARY REPLICATION-REPAIR DEFICIENT (RRD) GLIOMAS REVEALS THREE SUBGROUPS WITH DISTINCT DRIVERS AND RESPONSE TO IMMUNOTHERAPY: AN IRRDC REPORT by Fernandez, Nicholas R, Das, Anirban, Levine, Adrian, Negm, Logine, Nobre, Liana, Bianchi, Vanessa, Stengs, Lucie, Chung, Jiil, Nunes, Nuno M, Edwards, Melissa, Bouffet, Eric, Hawkins, Cynthia, Tabori, Uri

“…Abstract BACKGROUND Replication-repair deficiency (RRD) caused by germline/somatic defects in mismatch repair (MMRD) and/or polymerase-proofreading genes (PPD)…”
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BIOL-18. NEWLY DEVELOPED REPLICATION REPAIR DEFICIENT (RRD) MOUSE MODELS PROVIDE INSIGHTS INTO MEDULLOBLASTOMA/GLIOMAGENESIS AND RESPONSE TO IMMUNOTHERAPY by Aamir, Zoya, Galati, Melissa, Gattoni, Emma, Crump, Owen, Nunes, Nuno M, Das, Anirban, Fernandez, Nicholas R, Wong, Angel K Q, Fortin, Jerome, Stengs, Lucie, Bianchi, Vanessa, Edwards, Melissa, Negm, Logine, Chung, Jiil, Malkin, David, Egan, Sean, Hawkins, Cynthia, Tabori, Uri

“…Abstract Replication Repair Deficiency (RRD), caused by germline monoallelic (Lynch Syndrome) or biallelic (Constitutional Mismatch Repair Deficiency, CMMRD)…”
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MDB-12. TRANS-SPECIES ANALYSIS OF REPLICATION-REPAIR DEFICIENT (RRD) MEDULLOBLASTOMA AND RESPONSE TO IMMUNE-CHECKPOINT INHIBITION: AN IRRDC REPORT by Das, Anirban, Fernandez, Nicholas R, Levine, Adrian, Smith, Kyle, Wang, Evan, Galati, Melissa, Aamir, Zoya, Chung, Jill, Negm, Logine, Crump, Owen, Trinh, Quang, Nunes, Nuno M, Bianchi, Vanessa, Stengs, Lucie, Edwards, Melissa, Stein, Lincoln, Bouffet, Eric, Taylor, Michael, Northcott, Paul, Ramaswamy, Vijay, Hawkins, Cynthia, Tabori, Uri

“…Abstract BACKGROUND Replication-repair deficiency (RRD) stemming from mismatch repair and polymerase-proofreading gene defects (MMRD/PPD) lead to hypermutant…”
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MODL-25. REPLICATION REPAIR DEFICIENT MOUSE MODELS PROVIDE INSIGHT ON HYPERMUTANT BRAIN TUMOURS, MECHANISMS OF IMMUNE EVASION, AND COMBINATORIAL IMMUNOTHERAPY by Galati, Melissa, Li, Li, Sudhaman, Sumedha, Lipman, Tatiana, Stengs, Lucie, Elshaer, Dana, Bridge, Taylor, Semenova, Dar’ya, Edwards, Melissa, Hodel, Karl, Forster, Victoria J, Nunes, Nuno M, Martin, Alberto, Bouffet, Eric, Pursell, Zachary, Hawkins, Cynthia, Tabori, Uri

“…Abstract Replication repair deficiency (RRD) is the leading cause of hypermutant brain tumours in children. RRD is caused by defects in one of four mismatch…”
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LGG-41. The clinical and molecular landscape of gliomas in adolescents and young adults by Bennett, Julie, Nobre, Liana, Sheth, Javal, Ryall, Scott, Fang, Karen, Johnson, Monique, Negm, Logine, Chung, Jiil, Komosa, Martin, Nunes, Nuno M, Fat, Mary Jane Lim, Perry, James, Sahgal, Arjun, Detsky, Jay, Bouffet, Eric, Naz-Hazrati, Lili, Dirks, Peter, Ertl-Wagner, Birgit, Kongkham, Paul, Zadeh, Gelareh, Mason, Warren, Climans, Seth, Cusimano, Michael, Das, Sunit, Gao, Andrew, Tsang, Derek, Nguyen, Lananh, Laperriere, Normand, Keith, Julia, Munoz, David, Tabori, Uri, Hawkins, Cynthia

“…Abstract OBJECTIVE: Gliomas in adolescents and young adults (AYA) are commonly treated with a standard chemo-radiation approach based on data from adults. The…”
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THOR is a targetable epigenetic biomarker with clinical implications in breast cancer by Apolónio, Joana Dias, Dias, João S, Fernandes, Mónica Teotónio, Komosa, Martin, Lipman, Tatiana, Zhang, Cindy H, Leão, Ricardo, Lee, Donghyun, Nunes, Nuno Miguel, Maia, Ana-Teresa, Morera, José L, Vicioso, Luis, Tabori, Uri, Castelo-Branco, Pedro

“…Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the…”
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Abstract 1451: Replication repair deficient mouse models provide insights into gliomagenesis and response to immunotherapy by Aamir, Zoya, Galati, Melissa, Gattoni, Emma, Crump, Owen, Nunes, Nuno M., Das, Anirban, Fernandez, Nicholas, Wong, Angel K., Fortin, Jerome, Stengs, Lucie, Bianchi, Vanessa, Edwards, Melissa, Negm, Logine, Hawkins, Cynthia, Malkin, David, Egan, Sean, Tabori, Uri

“…Abstract Background: Replication Repair Deficiency (RRD), caused by germline monoallelic (Lynch Syndrome) or biallelic (Constitutional Mismatch Repair…”
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