Relationship between muscle strength and motor function in Duchenne muscular dystrophy

Relationship between muscle strength and motor function in Duchenne muscular dystrophy

ABSTRACT Measuring muscle strength and motor function is part of Duchenne muscular dystrophy (DMD) assessment. However, the relationship between these variables is controversial. Objective To investigate the relationship between muscle strength and motor function and between these variables and age....

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria Vol. 74; no. 7; pp. 530 - 535
Main Authors: Nunes, Milene F., Hukuda, Michele E., Favero, Francis M., Oliveira, Acary B., Voos, Mariana C., Caromano, Fátima A.
Format: Journal Article
Language:English
Published: Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil Thieme Revinter Publicações Ltda 01-07-2016
Academia Brasileira de Neurologia - ABNEURO
Academia Brasileira de Neurologia (ABNEURO)
Subjects:
Adolescent
Adult
Age Factors
atividade motora
Child
Cross-Sectional Studies
destreza motora
Disability Evaluation
Disease Progression
distrofia muscular de Duchenne
estatísticas não paramétricas
Female
força muscular
Humans
Male
Motor Activity - physiology
Muscle Strength - physiology
Muscular Dystrophy, Duchenne - physiopathology
Neuropsychological Tests
NEUROSCIENCES
PSYCHIATRY
Reference Values
Statistics, Nonparametric
Young Adult
muscle strength
estatísticas não paramétricas
força muscular
atividade motora
Statistics, Nonparametric
muscular dystrophy, Duchenne
destreza motora
motor skills
motor activity
distrofia muscular de Duchenne
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Summary:ABSTRACT Measuring muscle strength and motor function is part of Duchenne muscular dystrophy (DMD) assessment. However, the relationship between these variables is controversial. Objective To investigate the relationship between muscle strength and motor function and between these variables and age. Method Muscle strength was measured by Medical Research Council (MRC) scale and motor function, by Motor Function Measure (MFM), in 40 non-ambulatory patients. Spearman tests investigated the relationships between muscle strength, motor function and age. Results Total MRC and MFM scores were strongly related to each other (r = 0.94; p < 0.001), but not to age (r = -0.19, r = -0.31, respectively; p > 0.05). Strong and moderate relationships between partial muscle strength and motor function scores were found. Higher correlation coefficients were found between total scores and Dimensions 2 (axial/ proximal control) and 3 (distal control) of MFM. Conclusion Muscle strength and motor function are strongly correlated and seem to decrease proportionally in DMD.
Bibliography:ObjectType-Article-1
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ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/0004-282X20160085