Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk

Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk

The association between FokI polymorphism in the vitamin D receptor (VDR) gene and susceptibility to arterial hypertension (HT) is controversial. Thus, we evaluated the relation between FokI and HT according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline...

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Published in:Advances in nutrition (Bethesda, Md.) Vol. 11; no. 5; pp. 1211 - 1220
Main Authors: Nunes, Ivone F O C, Cavalcante, Ana A C M, Alencar, Marcus V O B, Carvalho, Marcos D F, Sarmento, José L R, Teixeira, Nayra S C C A, Paiva, Adriana A, Carvalho, Lídia R, Nascimento, Leopoldo F M, Cruz, Maria S P, Rogero, Marcelo M, Lima, Andréia C B, Carvalho, Cecilia M R G
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-09-2020
Oxford University Press
Subjects:
1,25(OH)2D
25(OH)D
Adult
Asian People
cardiovascular disease
Case-Control Studies
Genetic Predisposition to Disease
Humans
Hypertension - genetics
Polymorphism, Genetic
Receptors, Calcitriol - genetics
renin
Review
rs10735810
25(OH)D
cardiovascular disease
1,25(OH)2D
renin
rs10735810
1,25(OH)
D
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Summary:The association between FokI polymorphism in the vitamin D receptor (VDR) gene and susceptibility to arterial hypertension (HT) is controversial. Thus, we evaluated the relation between FokI and HT according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using MEDLINE® (Medical Literature Analysis and Retrieval System Online)/PubMed, Scopus, and Cochrane Library CENTRAL databases. Data from case-control studies, including the number of participants, age, 25-hydroxyvitamin D concentrations, systolic and diastolic blood pressure values, FokI allele, and genotype frequency were extracted by 2 independent authors and OR was calculated with the 95% CI to assess the strength of the association between the FokI variant and odds of HT. In general and subgroup analyses, we used allelic (f compared with F), common (ff compared with FF + Ff), risk (ff + Ff compared with FF), and additive (ff compared with FF) models. Six case-control studies including 3140 cases and 3882 controls were reviewed in the meta-analysis. Global assessment revealed a correlation between FokI and reduced odds of HT in the additive/homozygote model (ff compared with FF; OR: 0.65; 95% CI: 0.45–0.94) and common/recessive model (ff compared with FF + Ff; OR: 0.75; 95% CI: 0.57–0.99). In Asian subjects, there was a significant reduction in the odds of HT in additive (ff compared with FF; OR: 0.84; 95% CI: 0.73–0.98) and risk models (ff + Ff compared with FF; OR: 0.87, 95% CI: 0.78–0.97), in particular, for Indians (South). In Africans, the statistically significant association occurred in the additive and common models. Allele f in the FokI polymorphism of the VDR gene was associated with reduced odds of HT in the general population based on the risk model. Thus, nutritional genomics can help understand the influence of nutrition on metabolic homeostasis pathways and the clinical consequences of hypertension. This study shows the need for healthy, anti-inflammatory, and antioxidant compounds to prevent or treat chronic complications.
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ISSN:2161-8313
2156-5376
DOI:10.1093/advances/nmaa076