Search Results - "Nunes, Carolina da Silva"
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Assessment of Biocompatibility and Vascular Effects of Polymeric Materials Using Chick Chorioallantoic Membrane, an Alternative Method
Published in Macromolecular symposia. (01-12-2020)“…During the development of polymeric wound coating materials, the in vivo reactions play a key role in the success of the material for tissue engineering. In…”
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A New Topical Eye Drop Containing LyeTxI-b, A Synthetic Peptide Designed from A Lycosa erithrognata Venom Toxin, Was Effective to Treat Resistant Bacterial Keratitis
Published in Toxins (04-04-2019)“…Bacterial keratitis is an ocular infection that can lead to severe visual disability. is a major pathogen of the eye. We recently demonstrated the strong…”
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From the PnTx2-6 Toxin to the PnPP-19 Engineered Peptide: Therapeutic Potential in Erectile Dysfunction, Nociception, and Glaucoma
Published in Frontiers in molecular biosciences (11-04-2022)“…The venom of the "armed" spider comprises several potent toxins. One of the most toxic components from this venom is the neurotoxin PnTx2-6 (LD = ∼…”
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Intravitreal injection of peptides PnPa11 and PnPa13, derivatives of Phoneutria nigriventer spider venom, prevents retinal damage
Published in The journal of venomous animals and toxins including tropical diseases (2020)“…PnPa11 and PnPa13 are synthetic peptides derived from spider venom, which display antinociceptive and neuroprotective properties. In this work, we evaluated…”
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Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorio-allantoic membrane model
Published in The journal of venomous animals and toxins including tropical diseases (21-11-2018)“…The great diversity of molecules found in spider venoms include amino acids, polyamines, proteins and peptides, among others. Some of these compounds can…”
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Functional antagonism between nitrogen-fixing leguminous trees and calcicole-drought-tolerant trees in the Cerrado
Published in Acta Botânica Brasílica (01-01-2017)“…ABSTRACT The Cerrado is the largest savanna of South America and its physiognomy varies from savanna to woodlands. There are two main types of woodlands in the…”
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Early Acacia invasion in a sandy ecosystem enables shading mediated by soil, leaf nitrogen and facilitation
Published in Biological invasions (01-06-2018)“…Australian species of the genus Acacia are amongst the most invasive trees. As nitrogen fixers, they are able to invade oligotrophic ecosystems and alter…”
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Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone
Published in International journal of pharmaceutics (10-09-2019)“…[Display omitted] Some recent studies have shown that pirfenidone (PFD) has favorable results in the healing process of the cornea. However, PFD in solution…”
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Neurotoxic and convulsant effects induced by jack bean ureases on the mammalian nervous system
Published in Toxicology (Amsterdam) (30-04-2021)“…•Jack bean ureases, JBU and canatoxin (CNTX), cause seizures in rodents.•Electrophysiology and brain imaging were applied to study their mode of…”
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Improvement of PnPP-19 peptide bioavailability for glaucoma therapy: Design and application of nanowafers based on PVA
Published in Journal of drug delivery science and technology (01-08-2022)“…This study proposed the development and characterization of a system of drug nano-reservoirs, the nanowafers, containing PnPP-19, a synthetic peptide designed…”
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Intravitreal ketamine promotes neuroprotection in rat eyes after experimental ischemia
Published in Biomedicine & pharmacotherapy (01-01-2021)“…[Display omitted] •Intravitreal use of ketamine is safe for rat retina.•Ketamine have protective effects on retina injury induced by ischemia model.•The…”
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12
Squamous cell carcinoma in a kidney transplant recipient after 26 years
Published in Oral oncology reports (01-03-2024)“…Kidney transplantation is the preferred treatment for patients with end-stage renal disease. However, the immunosuppressive therapy used to prevent graft loss…”
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Assessment of the safety of intravitreal injection of metoprolol tartrate in rabbits
Published in Documenta ophthalmologica (01-02-2021)“…Purpose To verify the safety of different doses of intravitreal metoprolol tartrate (MT) after intravitreal injection in rabbit eyes. Methods Animals were…”
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PnPP-19 Peptide Restores Erectile Function in Hypertensive and Diabetic Animals Through Intravenous and Topical Administration
Published in Journal of sexual medicine (01-03-2019)“…With the aim of overcoming the high toxicity of PnTx2-6 (or δ-CNTX-Pn2a), a toxin from the venom of the armed spider (Phoneutria nigriventer), the 19-aminoacid…”
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PnTx2-6 (or δ-CNTX-Pn2a), a toxin from Phoneutria nigriventer spider venom, releases l-glutamate from rat brain synaptosomes involving Na+ and Ca2+ channels and changes protein expression at the blood-brain barrier
Published in Toxicon (Oxford) (01-08-2018)“…PhTx2 is the most toxic fraction from the venom of the spider Phoneutria nigriventer, being responsible to sodium entry into cortical synaptosomes, increasing…”
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Pathophysiological Effects of Lycosa erythrognatha Derived Peptide LyeTxI-b on RKO-AS-45-1 Colorectal Carcinoma Cell Line Using the Chicken Chorioallantoic Membrane Model
Published in International journal of peptide research and therapeutics (2022)“…The synthetic peptide derived from a spider toxin, Lycosa erithrognatha , LyeTxI-b, has known antitumoral and antiangiogenic activity. So, in this study we…”
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Crotoxin from Crotalus durissus terrificus snake venom induces the release of glutamate from cerebrocortical synaptosomes via N and P/Q calcium channels
Published in Toxicon (Oxford) (01-07-2014)“…Crotoxin (Crtx), the main toxin in the venom of Crotalus durissus terrificus snake, is a heterodimer with a basic subunit, CB, and an acidic subunit, CA. CB is…”
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Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitis
Published in Current research in pharmacology and drug discovery (2022)“…Uveitis is a group of sight-threatening ocular inflammatory disorders, whose mainstay of therapy is associated with severe adverse events, prompting the…”
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Metabolic groups of plants in neotropical hyperseasonal savannas threatened by Australian Acacia invasion
Published in Wetlands ecology and management (01-06-2023)“…The hyperseasonal savanna experiences regular flooding, drought stresses and is a neotropical vegetation type threatened by global change including Acacia spp…”
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Shading, nitrogen and soil texture rule a sandy savanna: Does facilitation rule its patchy physiognomy as well?
Published in Flora. Morphologie, Geobotanik, Oekophysiologie (01-02-2018)“…•This work aimed to understand assembly rules in a sandy savanna, a Mussununga.•Shading, leaf nitrogen and soil texture rule all physiognomies of that…”
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