Photoprotective potential of medicinal plants from Cerrado biome (Brazil) in relation to phenolic content and antioxidant activity

Photooxidative damage affects cellular lipids, proteins and DNA in addition to being involved in the pathobiochemistry of erythema formation, premature skin aging, photodermatoses development and skin cancer. Phenolic compounds, flavonoids and hydroxycinnamic acid esters protect plant tissues agains...

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Published in:	Journal of photochemistry and photobiology. B, Biology Vol. 189; pp. 119 - 123
Main Authors:	Nunes, Alesandra Ricardo, Rodrigues, Ana Livya Moreira, de Queiróz, Dinalva Brito, Vieira, Icaro Gusmão Pinto, Neto, João Francisco Câmara, Junior, João Tavares Calixto, Tintino, Saulo Relison, de Morais, Selene Maia, Coutinho, Henrique Douglas Melo
Format:	Journal Article
Language:	English
Published:	Switzerland Elsevier B.V 01-12-2018 Elsevier BV
Subjects:	Absorption Aging Antioxidant Antioxidants Antioxidants - pharmacology Brazil Cancer Deoxyribonucleic acid DNA Ecosystems Erythema Esters Flavonoids Flavonoids - pharmacology Flowers & plants Glycosides Herbal medicine Hydroxycinnamic acid Lipids Medicinal plants Phenolic compounds Phenols Phenols - pharmacology Photoprotective Plant extracts Plant protection Plant tissues Plants (botany) Plants, Medicinal - chemistry Protective Agents - pharmacology Proteins Quercetin Radiation absorption Scavenging Skin cancer Sun Sun Protection Factor Sun screens Sunscreening Agents Sunscreens Ultraviolet radiation Ultraviolet Rays - adverse effects Brazil Sun protection factor Phenolic compounds Antioxidant Photoprotective Plant extracts
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Summary:	Photooxidative damage affects cellular lipids, proteins and DNA in addition to being involved in the pathobiochemistry of erythema formation, premature skin aging, photodermatoses development and skin cancer. Phenolic compounds, flavonoids and hydroxycinnamic acid esters protect plant tissues against harmful UV-radiation. This study aimed to evaluate the sun protection factor of several Brazilian plant extracts in relation to UVB radiation absorption, which causes skin cancer, and to correlate the findings with their antioxidant activity, as well as with total phenol and flavonoid content. The antioxidant activity of the extracts were evaluated using the DPPH radical scavenging test. The photoprotective effect was evaluated using the methodology developed by Mansur. The antioxidant activity from the extracts showed IC50 values ranging from 4.91 to 132.24 μg/mL when compared to the standard quercetin with an IC50 of 5.01 μg/mL; the phenolic content varied from 3.77 to 57.14 mg GAE/g extract while flavonoid content varied from 1.80 to 5.89 mg EQ/g extract. Almost all extracts showed a potential for UVB radiation absorption in accordance with the ANVISA (Agência Nacional de Vigilância Sanitária) technical regulation for cosmetic sunscreens. The extracts with greater sun protection factors were those originating from Lippia microphylla (SPF = 26.82) and Dimorphandra gardneriana (SPF = 20.12). A sun protection factor of 15 or higher contributes to protect the skin, where the presence of sakuranetin flavonoids and quercetin glycosides contribute to this action. •The plants A. cearenses, A. cuspa, C. americana, L. microphylla, D. gardneriana and Luehea paniculata are promising.•50% of the extracts showed SPF ≥ 15 highlighting.•L. microphylla and Dimorphandra gardneriana presented high sun protector factor.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1011-1344 1873-2682
DOI:	10.1016/j.jphotobiol.2018.10.013