Search Results - "Nummy, Laurence J."

Formation of 2-Trifluoromethylphenyl Grignard Reagent via Magnesium−Halogen Exchange: Process Safety Evaluation and Concentration Effect by Tang, Wenjun, Sarvestani, Max, Wei, Xudong, Nummy, Laurence J, Patel, Nitinchandra, Narayanan, Bikshandarkoil, Byrne, Denis, Lee, Heewon, Yee, Nathan K, Senanayake, Chris H

“…The thermal stability profile for a solution of 2-trifluoromethylphenyl magnesium chloride at 1.5 M concentration in THF was determined using an Advanced…”
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Synthesis of a Sodium–Hydrogen Exchange Type 1 Inhibitor: An Efficient Cu-Catalyzed Conjugated Addition of a Grignard Reagent to an Acetyl Pyridinium Salt by Tang, Wenjun, Patel, Nitinchandra D, Wei, Xudong, Byrne, Denis, Chitroda, Ashish, Narayanan, Bikshandarkoil, Sienkiewicz, Alexander, Nummy, Laurence J, Sarvestani, Max, Ma, Shengli, Grinberg, Nelu, Lee, Heewon, Kim, Soojin, Li, Zhibin, Spinelli, Earl, Yang, Bing-Shiou, Yee, Nathan, Senanayake, Chris H

“…A facile and economical five-step process for the synthesis of a sodium–hydrogen exchange type I inhibitor (NHE-1) was developed from readily available…”
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Process Safety Evaluation of a Magnesium−Iodine Exchange Reaction by Reeves, Jonathan T, Sarvestani, Max, Song, Jinhua J, Tan, Zhulin, Nummy, Laurence J, Lee, Heewon, Yee, Nathan K, Senanayake, Chris H

“…An unexpected highly exothermic decomposition was observed during routine safety analysis of the magnesium−iodine exchange reaction of 2-iodo-4-fluorotoluene…”
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Practical Synthesis of an Enantiomerically Pure trans-4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB4 Inhibitor BIRZ-227 by Yee, Nathan K, Nummy, Laurence J, Byrne, Denis P, Smith, Lana L, Roth, Gregory P

“…A practical synthesis of the enantiomerically pure BIRZ-227 (1), a LTB4 inhibitor, has been developed. The key steps include the effective synthesis of the…”
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Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters by Yee, Nathan K., Nummy, Laurence J., Frutos, Rogelio P., Song, Jinhua J., Napolitano, Elio, Byrne, Denis P., Jones, Paul-James, Farina, Vittorio

“…An efficient enantiospecific synthesis of the cell adhesion inhibitor BIRT-377 by self-regeneration of stereocenters has been achieved in 38% overall yield in…”
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Synthesis of five nevirapine metabolites by Grozinger, Karl G., Byrne, Denis P., Nummy, Laurence J., Ridges, Michael D., Salvagno, Annette

“…Nevirapine (1) is a non‐nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune® since 1996. In vitro studies…”
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Practical Synthesis of an Enantiomerically Pure trans- 4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB 4 Inhibitor BIRZ-227 by Yee, Nathan K., Nummy, Laurence J., Byrne, Denis P., Smith, Lana L., Roth, Gregory P.

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