Search Results - "Numis, Adam L."

Early and effective treatment of KCNQ2 encephalopathy by Pisano, Tiziana, Numis, Adam L., Heavin, Sinéad B., Weckhuysen, Sarah, Angriman, Marco, Suls, Arvid, Podesta, Barbara, Thibert, Ronald L., Shapiro, Kevin A., Guerrini, Renzo, Scheffer, Ingrid E., Marini, Carla, Cilio, Maria Roberta

“…Summary Objectives To describe the antiepileptic drug (AED) treatment of patients with early infantile epileptic encephalopathy due to KCNQ2 mutations during…”
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Simulation-based inference of developmental EEG maturation with the spectral graph model by Bernardo, Danilo, Xie, Xihe, Verma, Parul, Kim, Jonathan, Liu, Virginia, Numis, Adam L., Wu, Ye, Glass, Hannah C., Yap, Pew-Thian, Nagarajan, Srikantan S., Raj, Ashish

“…The spectral content of macroscopic neural activity evolves throughout development, yet how this maturation relates to underlying brain network formation and…”
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Comparison of multiplex cytokine assays in a pediatric cohort with epilepsy by Numis, Adam L., Fox, Christine H., Lowenstein, Daniel J., Norris, Philip J., Di Germanio, Clara

“…Multiplex analyses allow for detection of dozens of cytokines/chemokines in small sample volumes. Although several commercially available assay kits are…”
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Neonatal Seizure Management: What Is Timely Treatment and Does It Influence Neurodevelopment? by Numis, Adam L., Shellhaas, Renée A.

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Neonatal presentation of genetic epilepsies: Early differentiation from acute provoked seizures by Cornet, Marie‐Coralie, Morabito, Valeria, Lederer, Damien, Glass, Hannah C., Ferrao Santos, Susana, Numis, Adam L., Ferriero, Donna M., Sands, Tristan T., Cilio, Maria Roberta

“…Objective Although most seizures in neonates are due to acute brain injury, some represent the first sign of neonatal onset genetic epilepsies. Delay in…”
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Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures by Glass, Hannah C, Soul, Janet S, Chang, Taeun, Wusthoff, Courtney J, Chu, Catherine J, Massey, Shavonne L, Abend, Nicholas S, Lemmon, Monica, Thomas, Cameron, Numis, Adam L, Guillet, Ronnie, Sturza, Julie, McNamara, Nancy A, Rogers, Elizabeth E, Franck, Linda S, McCulloch, Charles E, Shellhaas, Renée A

“…Antiseizure medication (ASM) treatment duration for acute symptomatic neonatal seizures is variable. A randomized clinical trial of phenobarbital compared with…”
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Lack of response to quinidine in KCNT1‐related neonatal epilepsy by Numis, Adam L., Nair, Umesh, Datta, Anita N., Sands, Tristan T., Oldham, Michael S., Patel, Akash, Li, Melody, Gazina, Elena, Petrou, Steven, Cilio, Maria Roberta

“…Summary Objective To evaluate the clinical efficacy and safety of quinidine in patients with KCNT1‐related epilepsy of infancy with migrating focal seizures…”
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Clinical/Scientific Notes by NUMIS, Adam L, ANGRIMAN, Marco, SULLIVAN, Joseph E, LEWIS, Ann J, STRIANO, Pasquale, NABBOUT, Rima, CILIO, Maria R

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Machine learning for forecasting initial seizure onset in neonatal hypoxic–ischemic encephalopathy by Bernardo, Danilo, Kim, Jonathan, Cornet, Marie‐Coralie, Numis, Adam L., Scheffler, Aaron, Rao, Vikram R., Amorim, Edilberto, Glass, Hannah C.

“…Abstract Objective This study was undertaken to develop a machine learning (ML) model to forecast initial seizure onset in neonatal hypoxic–ischemic…”
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KCNQ2 encephalopathy: Delineation of the electroclinical phenotype and treatment response by Numis, Adam L, Angriman, Marco, Sullivan, Joseph E, Lewis, Ann J, Striano, Pasquale, Nabbout, Rima, Cilio, Maria R

“…Neonatal-onset epilepsies are rare conditions, mostly genetically determined, that can have a benign or severe phenotype.(1,2) There is recent recognition of…”
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Whole-exome sequencing with targeted analysis and epilepsy after acute symptomatic neonatal seizures by Numis, Adam L., da Gente, Gilberto, Sherr, Elliott H., Glass, Hannah C.

“…Background The contribution of pathogenic gene variants with development of epilepsy after acute symptomatic neonatal seizures is not known. Methods…”
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Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy by Numis, Adam L., Foster-Barber, Audrey, Deng, Xutao, Rogers, Elizabeth E., Barkovich, A. James, Ferriero, Donna M., Glass, Hannah C.

“…Background Neonatal seizures are associated with adverse neurologic sequelae including epilepsy in childhood. Here we aim to determine whether levels of…”
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Assessing Early Severity of Hypoxic-Ischemic Encephalopathy: The Role of Electroencephalogram Background in Addition to Sarnat Exam by Cornet, Marie-Coralie, Numis, Adam L., Monsell, Sarah E., Chan, Natalie H., Gonzalez, Fernando F., Comstock, Bryan A., Juul, Sandra E., Wusthoff, Courtney J., Wu, Yvonne W., Glass, Hannah C.

“…To assess the relationship between the Sarnat exam, early electroencephalogram (EEG) background, and death or neurodevelopmental impairment (NDI) at age two…”
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Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology by Hussain, Shaun A., Heesch, Jaeden, Weng, Julius, Rajaraman, Rajsekar R., Numis, Adam L., Sankar, Raman

“…•We observed an association between voltage-gated sodium channel blockade and shorter latency to epileptic spasms.•Potential risk may be limited to patients…”
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Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1 by Szapacs, Matthew E, Numis, Adam L, Andrews, Anne M

“…Transgenic mice expressing both mutant amyloid precursor protein (APPswe) and presenilin-1 (PS1ΔE9) develop amyloid deposits as early as 4 months of age and…”
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WONOEP appraisal: Biomarkers of epilepsy‐associated comorbidities by Ravizza, Teresa, Onat, Filiz Y., Brooks‐Kayal, Amy R., Depaulis, Antoine, Galanopoulou, Aristea S., Mazarati, Andrey, Numis, Adam L., Sankar, Raman, Friedman, Alon

“…Summary Neurologic and psychiatric comorbidities are common in patients with epilepsy. Diagnostic, predictive, and pharmacodynamic biomarkers of such…”
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Outcomes After Acute Symptomatic Seizures in Children Admitted to a Neonatal Neurocritical Care Service by Glass, Hannah C., Numis, Adam L., Gano, Dawn, Bali, Varun, Rogers, Elizabeth E.

“…Neonatal seizures due to acute brain injury are associated with high rates of death, disability, and epilepsy. Our objective was to examine incidence of and…”
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WONOEP appraisal: Targeted therapy development for early onset epilepsies by Casillas‐Espinosa, Pablo M., Wong, Jennifer C., Grabon, Wanda, Gonzalez‐Ramos, Ana, Mantegazza, Massimo, Yilmaz, Nihan Carcak, Patel, Manisha, Staley, Kevin, Sankar, Raman, O'Brien, Terence J., Akman, Özlem, Balagura, Ganna, Numis, Adam L., Noebels, Jeffrey L., Baulac, Stéphanie, Auvin, Stéphane, Henshall, David C., Galanopoulou, Aristea S.

“…Abstract The early onset epilepsies encompass a heterogeneous group of disorders, some of which result in drug‐resistant seizures, developmental delay,…”
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Relationship of Neonatal Seizure Burden Before Treatment and Response to Initial Antiseizure Medication by Numis, Adam L., Glass, Hannah C., Comstock, Bryan A., Gonzalez, Fernando, Maitre, Nathalie L., Massey, Shavonne L., Mayock, Dennis E., Mietzsch, Ulrike, Natarajan, Niranjana, Sokol, Gregory M., Bonifacio, Sonia, Van Meurs, Krisa, Thomas, Cameron, Ahmad, Kaashif, Heagerty, Patrick, Juul, Sandra E., Wu, Yvonne W., Wusthoff, Courtney J.

“…To assess among a cohort of neonates with hypoxic–ischemic encephalopathy (HIE) the association of pretreatment maximal hourly seizure burden and total seizure…”
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Early‐life epilepsy after acute symptomatic neonatal seizures: A prospective multicenter study by Shellhaas, Renée A., Wusthoff, Courtney J., Numis, Adam L., Chu, Catherine J., Massey, Shavonne L., Abend, Nicholas S., Soul, Janet S., Chang, Taeun, Lemmon, Monica E., Thomas, Cameron, McNamara, Nancy A., Guillet, Ronnie, Franck, Linda S., Sturza, Julie, McCulloch, Charles E., Glass, Hannah C.

“…Objective We aimed to evaluate early‐life epilepsy incidence, seizure types, severity, risk factors, and treatments among survivors of acute neonatal seizures…”
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