Search Results - "Numerof, R P"

IL-2 stimulates the production of IL-1 alpha and IL-1 beta by human peripheral blood mononuclear cells by Numerof, RP, Aronson, FR, Mier, JW

“…Human PBMC were cultured in medium containing human rIL-2, and the supernatants and cell lysates were analyzed for IL-1 alpha and IL-1 beta using specific RIA…”
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Regulation by CD45 of the tyrosine phosphorylation of high affinity IgE receptor beta- and gamma-chains by Adamczewski, M, Numerof, RP, Koretzky, GA, Kinet, JP

“…Previous studies using tyrosine phosphatase inhibitors have implicated tyrosine phosphatases in the signal transduction pathway initiated by aggregation of Fc…”
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Induction of circulating tumor necrosis factor (TNFα) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients by MIER, J. W, VACHINO, G, VAN DER MEER, J. W. M, NUMEROF, R. P, ADAMS, S, CANNON, J. G, BERNHEIM, H. A, ATKINS, M. B, PARKINSON, D. R, DINARELLO, C. A

“…Fever is frequently observed in cancer patients treated with high-dose recombinant human interleukin-2 (rIL-2). The preincubation of rIL-2 with polymyxin B, an…”
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Inhibitors of tryptase for the treatment of mast cell-mediated diseases by Rice, K D, Tanaka, R D, Katz, B A, Numerof, R P, Moore, W R

“…Human tryptase is a structurally unique and mast cell specific trypsin-like serine protease. Recent biological and immunological investigations have implicated…”
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Pro-interleukin-1 beta production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2 by Numerof, R P, Kotik, A N, Dinarello, C A, Mier, J W

“…Previous studies have shown that IL-2-stimulated peripheral blood mononuclear cells (PBMC) produce IL-1 beta and TNF alpha and that monocytes are the primary…”
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Expression and Characterization of Recombinant Mast Cell Tryptase by Chan, Hedy, Elrod, Kyle C., Numerof, Robert P., Sideris, Steve, Clark, James M.

“…Tryptase, a serine protease, is the major protein component in mast cells. In an animal model of asthma, tryptase has been established as an important mediator…”
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Toxicity of immunotherapy with interleukin-2 and lymphokine-activated killer cells by Mier, J W, Aronson, F R, Numerof, R P, Vachino, G, Atkins, M B

“…Immunotherapy with IL-2 represents a major breakthrough in the management of renal cell carcinoma and malignant melanoma. At present, the toxicity of most IL-2…”
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Induction of Foxp3 super(+) regulatory T cells with histone deacetylase inhibitors by Lucas, J L, Mirshahpanah, P, Haas-Stapleton, E, Asadullah, K, Zollner, T M, Numerof, R P

“…Histone deacetylase inhibitors are under investigation in the clinic as a new class of anti-cancer therapeutics. While recent studies have also suggested their…”
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Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1 receptor antagonist by Numerof, R P, Sipe, J D, Trehu, E G, Dinarello, C A, Mier, J W

“…The hepatic acute phase response induced by the administration of interleukin (IL)-2 is most likely mediated by secondary cytokines. In this investigation, we…”
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Signal transduction through the conserved motifs of the high affinity IgE receptor FcεRI by Jouvin, Marie-Hélène, Numerof, Robert P., Kinet, Jean-Pierre

“…The high affinity receptor for IgE, FcεRI, possesses three ARAMs, one in the β chain (ARAM- β) and one in each member of the dimer of γ chains (ARAM- γ). These…”
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Cytokines as potential therapeutic targets for inflammatory skin diseases by Numerof, Robert P, Dinarello, Charles A, Asadullah, Khusru

“…A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous inflammatory diseases. Thus, the delineation of precise roles…”
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