Prognostic significance of expression of thymidine phosphorylase and vascular endothelial growth factor in human gastric carcinoma

Background and Objectives Both thymidine phosphorylase (dThdPase) and vascular endothelial growth factor (VEGF) are well‐characterized inducers of angiogenesis. The purpose of this study was to examine the expression of these antigens and their prognostic significance in gastric carcinoma. Methods M...

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Bibliographic Details
Published in:	Journal of surgical oncology Vol. 76; no. 1; pp. 31 - 36
Main Authors:	Kimura, Hironobu, Konishi, Kohji, Nukui, Takefumi, Kaji, Masahide, Maeda, Kiichi, Yabushita, Kazuhisa, Tsuji, Masahiko, Miwa, Atsuo
Format:	Journal Article
Language:	English
Published:	New York John Wiley & Sons, Inc 01-01-2001 Wiley-Liss
Subjects:	Adult Aged angiogenesis Biological and medical sciences dThdPase Endothelial Growth Factors - metabolism Female gastric carcinoma Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry liver metastasis Lymphokines - metabolism Male Medical sciences Middle Aged Neoplasm Invasiveness Prognosis Retrospective Studies Stomach Neoplasms - chemistry Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Thymidine Phosphorylase - metabolism Tumors Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors VEGF Human Immunohistochemistry Stomach Correlation Prognosis Enzyme Transferases Glycosyltransferases Stage classification Tumoral marker Metastasis Malignant tumor Gene expression Angiogenesis Vascular endothelium growth factor Cohort study Digestive diseases Pentosyltransferases Thymidine phosphorylase Gastric disease
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Summary:	Background and Objectives Both thymidine phosphorylase (dThdPase) and vascular endothelial growth factor (VEGF) are well‐characterized inducers of angiogenesis. The purpose of this study was to examine the expression of these antigens and their prognostic significance in gastric carcinoma. Methods Medical records of 102 patients with stage II tumor were retrospectively reviewed. Primary tumors were studied by immunohistochemical staining for dThdPase and VEGF. Results Positive dThdPase expression was observed in 52 (51%) tumors and positive VEGF expression in 53 (52%) tumors. There was a significant correlation between the positive expression of VEGF and lymphatic invasion. The patients with dThdPase‐positive carcinoma showed a significantly worse prognosis than those with dThdPase‐negative carcinoma in stage II. Moreover, the frequency of hepatic recurrence was significantly higher in the patients with dThdPase‐positive and VEGF‐positive tumors than in those with dThdPase‐negative and VEGF‐negative tumors. Conclusions Combination analysis of dThdPase and VEGF expression in gastric carcinoma appears to be well‐characterized inductors of prognosis and metastasis. J. Surg. Oncol. 2001;76:31–36. © 2001 Wiley‐Liss, Inc.
Bibliography:	istex:C4BFDDAA8FC68341A0161690465D003B08804AB7 ArticleID:JSO1006 ark:/67375/WNG-G1TZ5ZCV-W ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-4790 1096-9098
DOI:	10.1002/1096-9098(200101)76:1<31::AID-JSO1006>3.0.CO;2-9