Search Results - "Nuki, G"

2016 updated EULAR evidence-based recommendations for the management of gout by Richette, P, Doherty, M, Pascual, E, Barskova, V, Becce, F, Castañeda-Sanabria, J, Coyfish, M, Guillo, S, Jansen, T L, Janssens, H, Lioté, F, Mallen, C, Nuki, G, Perez-Ruiz, F, Pimentao, J, Punzi, L, Pywell, T, So, A, Tausche, A K, Uhlig, T, Zavada, J, Zhang, W, Tubach, F, Bardin, T

“…New drugs and new evidence concerning the use of established treatments have become available since the publication of the first European League Against…”
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OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines by Zhang, W., Ph.D, Moskowitz, R.W., M.D, Nuki, G., M.B., F.R.C.P, Abramson, S., M.D, Altman, R.D., M.D, Arden, N., M.D, Bierma-Zeinstra, S., M.Sc., Ph.D, Brandt, K.D., M.D, Croft, P., M.D, Doherty, M., M.D, Dougados, M., M.D, Hochberg, M., M.D., M.P.H, Hunter, D.J., M.D, Kwoh, K., M.D, Lohmander, L.S., M.D, Tugwell, P., M.D

“…Summary Purpose To develop concise, patient-focussed, up to date, evidence-based, expert consensus recommendations for the management of hip and knee…”
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OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009 by Zhang, W, Nuki, G, Moskowitz, R W, Abramson, S, Altman, R D, Arden, N K, Bierma-Zeinstra, S, Brandt, K D, Croft, P, Doherty, M, Dougados, M, Hochberg, M, Hunter, D J, Kwoh, K, Lohmander, L S, Tugwell, P

“…To update evidence for available therapies in the treatment of hip and knee osteoarthritis (OA) and to examine whether research evidence has changed from 31…”
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Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005 by Annemans, L, Spaepen, E, Gaskin, M, Bonnemaire, M, Malier, V, Gilbert, T, Nuki, G

“…To investigate and compare the prevalence, comorbidities and management of gout in practice in the UK and Germany. A retrospective analysis of patients with…”
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OARSI recommendations for the management of hip and knee osteoarthritis, Part I: Critical appraisal of existing treatment guidelines and systematic review of current research evidence by Zhang, W., Ph.D, Moskowitz, R.W., M.D, Nuki, G., M.B., F.R.C.P, Abramson, S., M.D, Altman, R.D., M.D, Arden, N., M.Sc., M.R.C.P, Bierma-Zeinstra, S., Ph.D, Brandt, K.D., M.D, Croft, P., M.D, Doherty, M., M.D., F.R.C.P, Dougados, M., M.D, Hochberg, M., M.D, Hunter, D.J., M.B.B.S., Ph.D, Kwoh, K., M.D, Lohmander, L.S., M.D., Ph.D, Tugwell, P., M.D

“…Summary Purpose As a prelude to developing updated, evidence-based, international consensus recommendations for the management of hip and knee osteoarthritis…”
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EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT) by Zhang, W, Doherty, M, Bardin, T, Pascual, E, Barskova, V, Conaghan, P, Gerster, J, Jacobs, J, Leeb, B, Lioté, F, McCarthy, G, Netter, P, Nuki, G, Perez-Ruiz, F, Pignone, A, Pimentão, J, Punzi, L, Roddy, E, Uhlig, T, Zimmermann-Gòrska, I

“…Objective: To develop evidence based recommendations for the management of gout. Methods: The multidisciplinary guideline development group comprised 19…”
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EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the standing committee for international clinical studies including therapeutics (ESCISIT) by Zhang, W, Doherty, M, Pascual, E, Bardin, T, Barskova, V, Conaghan, P, Gerster, J, Jacobs, J, Leeb, B, Lioté, F, McCarthy, G, Netter, P, Nuki, G, Perez-Ruiz, F, Pignone, A, Pimentão, J, Punzi, L, Roddy, E, Uhlig, T, Zimmermann-Gòrska, I

“…Objective: To develop evidence based recommendations for the diagnosis of gout. Methods: The multidisciplinary guideline development group comprised 19…”
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Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading by Ramage, L., Nuki, G., Salter, D. M.

“…Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes and induces the synthesis of molecules to maintain the integrity…”
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Evidence for JNK-dependent up-regulation of proteoglycan synthesis and for activation of JNK1 following cyclical mechanical stimulation in a human chondrocyte culture model by Zhou, Y., M.D, Millward-Sadler, S.J., Ph.D, Lin, H., M.Phil, Robinson, H., M.D, Goldring, M., Ph.D, Salter, D.M., M.D, Nuki, G., M.B., F.R.C.P

“…Summary Objective To examine the expression of mitogen-activated protein kinases (MAPKs) in human chondrocytes, to investigate whether selective activation of…”
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Osteoarthritis : a problem of joint failure by NUKI, G

“…Osteoarthritis can be viewed as the clinical and pathological outcome of a range of disorders that results in structural and functional failure of synovial…”
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Response from authors: ‘OARSI update on the evidence for osteoarthritis therapies’ by Zhang, W, Nuki, G

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Cod liver oil (n-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis by Galarraga, B., Ho, M., Youssef, H. M., Hill, A., McMahon, H., Hall, C., Ogston, S., Nuki, G., Belch, J. J. F.

“…Objectives. Dose-dependant gastrointestinal and cardiovascular side-effects limit the use of NSAIDs in the management of RA. The n-3 essential fatty acids…”
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Integrin-Regulated Secretion of Interleukin 4: A Novel Pathway of Mechanotransduction in Human Articular Chondrocytes by Millward-Sadler, S. J., Wright, M. O., H.-S. Lee, Nishida, K., Caldwell, H., Nuki, G., Salter, D. M.

“…Chondrocyte function is regulated partly by mechanical stimulation. Optimal mechanical stimulation maintains articular cartilage integrity, whereas abnormal…”
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A multicentre, randomised, double blind, placebo controlled phase II study of subcutaneous interferon beta-1a in the treatment of patients with active rheumatoid arthritis by van Holten, J, Pavelka, K, Vencovsky, J, Stahl, H, Rozman, B, Genovese, M, Kivitz, A J, Alvaro, J, Nuki, G, Furst, D E, Herrero-Beaumont, G, McInnes, I B, Musikic, P, Tak, P P

“…Objective: To assess the efficacy of interferon beta (IFNβ) in combination with methotrexate in treatment of patients with rheumatoid arthritis. Methods: 209…”
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343 OARSI RECOMMENDATIONS FOR THE MANAGEMENT OF HIP AND KNEE OSTEOARTHRITIS:WHICH TREATMENTS ARE BEING USED? AUDIT OF PATIENTS COMING TO ARTHROPLASTY IN SCOTLAND by Beadle, C, Howie, C.R, Nuki, G

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Macrovascular disease and systemic sclerosis by Ho, Meilien, Veale, Douglas, Eastmond, Clifford, Nuki, George, Belch, Jill

“…OBJECTIVE To determine if macrovascular disease is more prevalent in systemic sclerosis (SSc) compared with unaffected subjects. METHODS 54 patients with SSc…”
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I-4 RESOURCES FOR FUTURE GUIDELINES & RESEARCH: AN OARSI ‘TOOLBOX’ AND AN ‘EVIDENCE-BASED OA RESEARCH DATABASE’ (EBOARD) by Zhang, W, Nuki, G

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Integrin and Mechanosensitive Ion Channel‐Dependent Tyrosine Phosphorylation of Focal Adhesion Proteins and β‐Catenin in Human Articular Chondrocytes After Mechanical Stimulation by Lee, H. S., Millward‐Sadler, S. J., Wright, M. O., Nuki, G., Salter, D. M.

“…Mechanical forces influence chondrocyte metabolism and function. We have previously shown that 0.33 Hz cyclical pressure‐induced strain (PIS) results in…”
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The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: a consensus report by BOONEN, S, RIZZOLI, R, MEUNIER, P. J, STONE, M, NUKI, G, SYVERSEN, U, LEHTONEN-VEROMAA, M, LIPS, P, JOHNELL, O, REGINSTER, J.-Y

“…A European Union (EU) directive on vitamins and minerals used as ingredients of food supplements with a nutritional or physiological effect (2002/46/EC) was…”
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249 FGF/VEGF RECEPTOR-DEPENDENT, INTEGRIN-INDEPENDENT PHOSPHORYLATION OF P38, JNK AND ERK MAPKS FOLLOWING MECHANICAL STIMULATION OF NORMAL AND OA HUMAN ARTICULAR CHONDROCYTES IN PRIMARY MONOLAYER CELL CULTURE by Zhou, Y, Beadle, C, Salter, D.M, Nuki, G

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