Association of testosterone level with melasma in men: a case-control study in Indonesia

melasma is a common acquired hypermelanosis which occurs mostly in face that caused by many factors. One of the pathogenesis of melasma in men is affected by testosterone. This study aimed to investigate the relationship between testosterone levels and melasma in men and its association with the sev...

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Bibliographic Details
Published in:	The Pan African medical journal Vol. 43; p. 194
Main Authors:	Nukana, Ratih Purnamasari, Rusyati, Luh Made Mas, Praharsini, Gusti Ayu Agung, Winaya, Ketut Kwartantaya, Suryawati, Nyoman, Karna, Ni Luh Putu Ratih Vibriyanti
Format:	Journal Article
Language:	English
Published:	Uganda The African Field Epidemiology Network 2022
Subjects:	Case-Control Studies Humans Indonesia - epidemiology Male Melanosis - epidemiology Melanosis - etiology Research Design Treatment Outcome Indonesia Melasma testosterone low men
Online Access:	Get full text
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Summary:	melasma is a common acquired hypermelanosis which occurs mostly in face that caused by many factors. One of the pathogenesis of melasma in men is affected by testosterone. This study aimed to investigate the relationship between testosterone levels and melasma in men and its association with the severity of melasma as measured by the melasma area and severity index (MASI) score. a case-control study involving 30 subjects with melasma and 30 subjects without melasma who were treated at the outpatient clinic of Dermatovenereology of Ngoerah General Hospital from June to August 2022. Descriptive statistical analysis is to determine frequencies and percentages. Bivariate analysis was used to find any risk factor between testosterone level and melasma. Data obtained from the two groups then analyzed for correlation between the MASI score and testosterone levels. mean age of the subjects in the melasma group was 43.83±6.30 and in control group was 43.80±6.09. Mean testosterone level in the melasma group (7.55±1.77) was significantly lower than the control group (21.07±6.65; p = 0.001). Subject with testosterone level ≥8.92 nmol/L has 6.9 times risk of melasma compare to control (aOR: 6.986, 95% CI 1.905-25.622; p = 0.003). low testosterone levels possibly have a role in pathogenesis of melasma in men.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1937-8688 1937-8688
DOI:	10.11604/pamj.2022.43.194.37435