Search Results - "Nuijens, J"

Spontaneous haemorrhage of hepatic adenoma in a patient addicted to anabolic steroids by Smit, D L, Nuijens, J H, de Ronde, W

“…This case report describes a patient with a nearly fatal spontaneous haemorrhage of a hepatic adenoma that occurred in association with anabolic androgenic…”
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Human Lactoferrin and Peptides Derived from Its N Terminus Are Highly Effective against Infections with Antibiotic-Resistant Bacteria by NIBBERING, P. H, RAVENSBERGEN, E, WELLING, M. M, VAN BERKEL, L. A, VAN BERKEL, P. H. C, PAUWELS, E. K. J, NUIJENS, J. H

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Lactoferrin is a lipid A-binding protein by APPELMELK, B. J, YUN-QING AN, GEERTS, M, THIJS, B. G, DE BOER, H. A, MACLAREN, D. M, DE GRAAFF, J, NUIJENS, J. H

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Interleukin-8 in sepsis: relation to shock and inflammatory mediators by HACK, C. E, HART, M, STRACK VAN SCHIJNDEL, R. J. M, EERENBERG, A. J. M, NUIJENS, J. H, THIJS, L. G, AARDEN, L. A

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Sub-chronic (13-week) oral toxicity study in rats with recombinant human lactoferrin produced in the milk of transgenic cows by Appel, M.J., van Veen, H.A., Vietsch, H., Salaheddine, M., Nuijens, J.H., Ziere, B., de Loos, F.

“…The oral toxicity of recombinant human lactoferrin (rhLF) produced in the milk of transgenic cows was investigated in Wistar rats by daily administration via…”
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Large scale production of recombinant human lactoferrin in the milk of transgenic cows by Ravensbergen, Bep, Pauwels, Ernest K. J, Salaheddine, Mourad, van Berkel, Patrick H.C, Welling, Mick M, Geerts, Marlieke, van Veen, Harry A, Nibbering, Peter H, Nuijens, Jan H, Pieper, Frank

“…The limited capacity of current bioreactors has led the biopharmaceutical industry to investigate alternative protein expression systems. The milk of…”
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Granulocyte Colony-Stimulating Factor Administration to Healthy Volunteers: Analysis of the Immediate Activating Effects on Circulating Neutrophils by Haas, Masja de, Kerst, J. Martijn, van der Schoot, C. Ellen, Calafat, Jero, Hack, C. Erik, Nuijens, Jan H., Roos, Dirk, van Oers, Rien H.J., von dem Borne, Albert E.G.Kr

“…In four healthy volunteers, we analyzed in detail the immediate in vivo effects on circulating neutrophils of subcutaneous administration of 300 µg of…”
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Characterization of bovine neutrophil gelatinase-associated lipocalin by van Veen, H A, Geerts, M E J, Zoetemelk, R A A, Nuijens, J H, van Berkel, P H C

“…A protein of relative molecular mass of approximately 25,000 was purified from bovine colostrum by cation-exchange and size-exclusion chromatography. The…”
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Glycosylated and unglycosylated human lactoferrins both bind iron and show identical affinities towards human lysozyme and bacterial lipopolysaccharide, but differ in their susceptibilities towards tryptic proteolysis by van Berkel, P H, Geerts, M E, van Veen, H A, Kooiman, P M, Pieper, F R, de Boer, H A, Nuijens, J H

“…We studied the role of N-glycosylation of human lactoferrin (hLF) with respect to properties that are relevant to its antibacterial and anti-inflammatory…”
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Inactivation of Factor XIa in Human Plasma Assessed by Measuring Factor XIa-Protease Inhibitor Complexes: Major Role for C1-Inhibitor by Wuillemin, Walter A., Minnema, Monique, Meijers, Joost C.M., Roem, Dorina, Eerenberg, Anke J.M., Nuijens, Jan H., Cate, Hugo ten, Hack, C.Erik

“…From experiments with purified proteins, it has been concluded that factor XIa (FXIa) is inhibited in plasma mainly by α1-antitrypsin (a1AT), followed by…”
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Human lactoferrin in the milk of transgenic mice increases intestinal growth in ten-day-old suckling neonates by Zhang, P, Sawicki, V, Lewis, A, Hanson, L, Nuijens, J H, Neville, M C

“…Regulatory roles and a signaling receptor have been proposed for the milk protein lactoferrin (Lf), but none has been definitively characterized. Nichols and…”
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Clinical Studies of Recombinant Human C1 Inhibitor (rhC1INH) in Patients with Acute Attacks of Hereditary Angioedema by Nuijens, J, Verdonk, R, Giannetti, B, Visscher, S, van Doorn, M, Resink, T, Levi, M, Hack, C, Farkas, H, Obtulowicz, K, Caballero, T, Cicardi, M

“…Methods The safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of intravenously administered rhC1INH were evaluated in open-label…”
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Increased Plasma Levels of Interleukin-6 in Sepsis by Hack, C. Erik, De Groot, Els R., Fert-Bersma, Richelle J.F., Nuijens, Jan H., Strack Van Schijndel, Rob J.M., Eerenberg-Belmer, Anke J.M., Thijs, Lambertus G., Aarden, Lucien A.

“…lnterleukin-6 (IL-6) is likely to be an important mediator of the inflammatory response. We measured levels of this cytokine in plasma samples from 37 patients…”
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Structure and biological actions of lactoferrin by Nuijens, J H, van Berkel, P H, Schanbacher, F L

“…Lactoferrin is an iron-binding glycoprotein of the transferrin family, first isolated from milk but also found in most exocrine secretions as well as in the…”
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Soluble Fcγ receptor III in human plasma originates from release by neutrophils by HUIZINGA, T. W. J, DE HAAS, M, KLEIJER, M, NUIJENS, J. H, ROOS, D, VON DEM BORNE, A. E. G. K

“…FcRIII (the CD16-antigen), a low affinity receptor for IgG, is expressed by neutrophils, natural killer lymphocytes, and macrophages. We have developed a…”
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A phase I study of recombinant human C1 inhibitor (RHC1INH) in asymptomatic patients with hereditary angioedema (HAE) by Doorn, M., Nuijens, J., Schoemaker, R., Burggraaf, K., Cohen, A.

“…HAE patients experience recurrent episodes of localized swelling of submucosal and/or subcutaneous tissue. An attack is life‐threatening when occurring in the…”
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Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1 by Otto, B R, van Dooren, S J, Nuijens, J H, Luirink, J, Oudega, B

“…Many pathogenic bacteria can use heme compounds as a source of iron. Pathogenic Escherichia coli strains are capable of using hemoglobin as an iron source…”
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Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation by Wachtfogel, Y T, Hack, C E, Nuijens, J H, Kettner, C, Reilly, T M, Knabb, R M, Bischoff, R, Tschesche, H, Wenzel, H, Kucich, U

“…Cardiopulmonary bypass causes hemorrhagic complications and initiates a biochemical and cellular "whole body inflammatory response." This study investigates…”
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Clinical studies of recombinant human C1 inhibitor in subjects with hereditary angioedema by Nuijens, J., Verdonk, R., van Doorn, M., Burggraaf, K., Cohen, A., Choi, G., Soeters, M., Hack, E., Levi, M., Sisk, E., Pinciaro, P.

“…The positive open-label Phase I and II trial results warrant randomized controlled trials to unequivocally demonstrate the efficacy and extend observations of…”
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Proteolytic inactivation of plasma C1 inhibitor in sepsis by NUIJENS, J. H, EERENBERG-BELMER, A. J. M, HUIJBREGTS, C. C. M, SCHREUDER, W. O, FELT-BERSMA, R. J. F, ABBINK, J. J, THIJS, L. G, HACK, C. E

“…Activation of both the complement system and the contact system of intrinsic coagulation is implicated in the pathophysiology of sepsis. Because C1 inhibitor…”
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