The effect of ranitidine administration in graded dosage to the degree of liver damage: A study on Wistar rats with acute methanol intoxication

The high incidence of alcoholic poisoning in Indonesia is caused by the use of methanol as a surrogate ingredient of nonconforming alcohol. The product of methanol metabolism is toxic to the liver. Ranitidine has been studied as an antidote to reduce the effect of methanol toxicity. The present stud...

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Bibliographic Details
Published in:	Human & experimental toxicology Vol. 40; no. 3; p. 497
Main Authors:	Nugrahanti, M P, Armalina, D, Partiningrum, D L, Fulyani, F
Format:	Journal Article
Language:	English
Published:	England 01-03-2021
Subjects:	Animals Anti-Ulcer Agents - administration & dosage Antidotes - administration & dosage Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - pathology Dose-Response Relationship, Drug Liver - drug effects Liver - pathology Male Methanol - toxicity Ranitidine - administration & dosage Rats Rats, Wistar ranitidine Wistar rat liver Methanol intoxication
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Summary:	The high incidence of alcoholic poisoning in Indonesia is caused by the use of methanol as a surrogate ingredient of nonconforming alcohol. The product of methanol metabolism is toxic to the liver. Ranitidine has been studied as an antidote to reduce the effect of methanol toxicity. The present study aimed to assess the effect of ranitidine administration on the liver damage of Wistar rats with acute methanol intoxication. This research was an experimental study with randomized and posttest-only control group design. A total of 24 male Wistar rats divided into four groups, each consisting of six Rats. The control group (K0) served as a reference normal value. The control group (K1) was intoxicated with methanol 7 g/kg body weight (b.w.) through rat gavage tube. Treatment groups were intoxicated with methanol and 15 minutes after that, Ranitidine (30 mg/kg b.w. (P1) or 60 mg/kg b.w. (P2)) was given intraperitoneally. Ranitidine administration was proven to protect the liver tissue from damage due to methanol intoxication as was indicated from the histopathological examination. Ranitidine with dose 60 mg/kg b.w. is better in reducing the degree of liver tissue damage in acute methanol intoxication rats.
ISSN:	1477-0903
DOI:	10.1177/0960327120954529