Stereotactic radiosurgery to surgical cavity post resection of brain metastases: Local recurrence and overall survival rates. A single‐centre experience

Introduction We reviewed local control (LC) and overall survival (OS) post intracranial SRS to cavity post resection of brain metastases at one institution, and factors affecting LC. Methods A retrospective review was conducted of adjuvant SRS at one institution from 2013 to 2016. Patient records, t...

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Published in:	Journal of medical imaging and radiation oncology Vol. 62; no. 5; pp. 726 - 733
Main Authors:	Higgins, Martin J, Burke, Orlaidh, Fitzpatrick, David, Nugent, Killian G, Skourou, Christina, Dunne, Mary, Javadpour, Mohsen, Faul, Clare
Format:	Journal Article
Language:	English
Published:	Australia Wiley Subscription Services, Inc 01-10-2018
Subjects:	adjuvant stereotactic radiosurgery Adult Aged Brain Brain cancer brain metastases Brain Neoplasms - radiotherapy Brain Neoplasms - secondary Brain Neoplasms - surgery Continuity (mathematics) Diagnostic systems Failure analysis Female fractionated stereotactic radiosurgery Humans Magnetic resonance imaging Male Median (statistics) Medical imaging Metastasis Middle Aged Neoplasm Recurrence, Local Patients Radiology Radiosurgery - methods Radiotherapy Dosage Rank tests Retrospective Studies SRS stereotactic radiosurgery Surgery Survival Survival analysis Survival Rate Treatment Outcome adjuvant stereotactic radiosurgery fractionated stereotactic radiosurgery SRS brain metastases stereotactic radiosurgery
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Summary:	Introduction We reviewed local control (LC) and overall survival (OS) post intracranial SRS to cavity post resection of brain metastases at one institution, and factors affecting LC. Methods A retrospective review was conducted of adjuvant SRS at one institution from 2013 to 2016. Patient records, treatment plans and diagnostic images were reviewed. Local failure was MRI defined. Categorical variables were analysed using chi‐square and Fisher's exact tests. Continuous variables were analysed using Mann–Whitney tests. The Kaplan–Meier method was used to estimate survival times and the log‐rank test was used to compare differences in survival. Results Forty‐seven patients with 48 cavities were treated with SRS post operatively. LC rate was 69%, and the distant intracranial failure rate was 47% for entirety of the follow‐up period. The 12‐month freedom from local recurrence (FFLR) was 77% (63–91%). Median OS (95% CI) was 22.7 (14.6–30.8) months. Patients with a single metastasis had longer FFLR (30.1 vs 14.4 months; P = 0.014). Median interval from surgery to SRS was 6.3 weeks. Patients with interval >7 weeks had increased local recurrence (LR) (62%) than <7 weeks (37%), P = 0.025. Patients with a margin < 2 mm were more likely to experience LR (48%) than those with margin equal to 2 mm (20%); this approached statistical significance (P = 0.063). The median follow‐up for all patients was 15.4 months (2–41). Conclusions We determined LC and OS post adjuvant SRS at our institution. Based on the findings of this retrospective review SRS should be given promptly post operatively with a 2 mm PTV margin.
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ISSN:	1754-9477 1754-9485
DOI:	10.1111/1754-9485.12777