Search Results - "Núñez Galindo, Antonio"

Mitochondrial lysine deacetylation promotes energy metabolism and calcium signaling in insulin‐secreting cells by De Marchi, Umberto, Galindo, Antonio Núñez, Thevenet, Jonathan, Hermant, Aurélie, Bermont, Flavien, Lassueur, Steve, Domingo, Jaime Santo, Kussmann, Martin, Dayon, Loïc, Wiederkehr, Andreas

“…ABSTRACTIn pancreatic β‐cells, mitochondria generate signals that promote insulin granule exocytosis. Here we study how lysine acetylation of mitochondrial…”
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Mass spectrometry and DigiWest technology emphasize protein acetylation profile from Quisinostat-treated HuT78 CTCL cell line by Méhul, Bruno, Perrin, Agnes, Grisendi, Karine, Galindo, Antonio Núñez, Dayon, Loïc, Ménigot, Corinne, Rival, Yves, Voegel, Johannes J.

“…Histone deacetylases (HDACs) are key enzymes involved in epigenetic modulation and were targeted by HDAC inhibitors (HDACis) for cancer treatment. The action…”
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Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells by Santo-Domingo, Jaime, Galindo, Antonio Núñez, Cominetti, Ornella, De Marchi, Umberto, Cutillas, Pedro, Dayon, Loïc, Wiederkehr, Andreas

“…Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering…”
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Deep Dive on the Proteome of Human Cerebrospinal Fluid: A Valuable Data Resource for Biomarker Discovery and Missing Protein Identification by Macron, Charlotte, Lane, Lydie, Núñez Galindo, Antonio, Dayon, Loïc

“…Cerebrospinal fluid (CSF) is a body fluid of choice for biomarker studies of brain disorders but remains relatively under-studied compared with other…”
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Assessing normalization methods in mass spectrometry-based proteome profiling of clinical samples by Dubois, Etienne, Galindo, Antonio Núñez, Dayon, Loïc, Cominetti, Ornella

“…Large-scale proteomic studies have to deal with unwanted variability, especially when samples originate from different centers and multiple analytical batches…”
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Proteomics of Cerebrospinal Fluid: Throughput and Robustness Using a Scalable Automated Analysis Pipeline for Biomarker Discovery by Núñez Galindo, Antonio, Kussmann, Martin, Dayon, Loïc

“…Cerebrospinal fluid (CSF) is a body fluid of high clinical relevance and an important source of potential biomarkers for brain-associated damages, such as…”
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SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells by Santo-Domingo, Jaime, Lassueur, Steve, Galindo, Antonio Núñez, Alvarez-Illera, Pilar, Romero-Sanz, Silvia, Caldero-Escudero, Elena, de la Fuente, Sergio, Dayon, Loïc, Wiederkehr, Andreas

“…Glucose sensing in pancreatic β-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass…”
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Identification of Missing Proteins in Normal Human Cerebrospinal Fluid by Macron, Charlotte, Lane, Lydie, Núñez Galindo, Antonio, Dayon, Loïc

“…The cerebrospinal fluid (CSF) proteome data set presented herein was obtained after immunodepletion of abundant proteins and off-gel electrophoresis…”
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Proteomics of Human Milk: Definition of a Discovery Workflow for Clinical Research Studies by Dayon, Loïc, Macron, Charlotte, Lahrichi, Sabine, Núñez Galindo, Antonio, Affolter, Michael

“…Milk is a complex biological fluid composed mainly of water, carbohydrates, lipids, proteins, and diverse bioactive factors. Human milk represents a unique…”
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Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver by Wang, Jingkui, Mauvoisin, Daniel, Martin, Eva, Atger, Florian, Galindo, Antonio Núñez, Dayon, Loïc, Sizzano, Federico, Palini, Alessio, Kussmann, Martin, Waridel, Patrice, Quadroni, Manfredo, Dulić, Vjekoslav, Naef, Felix, Gachon, Frédéric

“…Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies…”
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Proteomes of Paired Human Cerebrospinal Fluid and Plasma: Relation to Blood–Brain Barrier Permeability in Older Adults by Dayon, Loïc, Cominetti, Ornella, Wojcik, Jérôme, Galindo, Antonio Núñez, Oikonomidi, Aikaterini, Henry, Hugues, Migliavacca, Eugenia, Kussmann, Martin, Bowman, Gene L, Popp, Julius

“…The systems-level relationship between the proteomes of cerebrospinal fluid (CSF) and plasma has not been comprehensively described so far. Recently developed…”
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Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue by Ling, Yiin, Carayol, Jérôme, Galusca, Bogdan, Canto, Carles, Montaurier, Christophe, Matone, Alice, Vassallo, Irene, Minehira, Kaori, Alexandre, Virginie, Cominetti, Ornella, Núñez Galindo, Antonio, Corthésy, John, Dayon, Loïc, Charpagne, Aline, Métairon, Sylviane, Raymond, Frédéric, Descombes, Patrick, Casteillo, François, Peoc–h, Michel, Palaghiu, Radu, Féasson, Léonard, Boirie, Yves, Estour, Bruno, Hager, Jörg, Germain, Natacha, Gheldof, Nele

“…Constitutional thinness (CT) is a state of low but stable body weight (BMI ≤18 kg/m2). CT subjects have normal-range hormonal profiles and food intake but…”
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Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate by Ducommun, Serge, Deak, Maria, Sumpton, David, Ford, Rebecca J., Núñez Galindo, Antonio, Kussmann, Martin, Viollet, Benoit, Steinberg, Gregory R., Foretz, Marc, Dayon, Loïc, Morrice, Nicholas A., Sakamoto, Kei

“…AMP-activated protein kinase (AMPK) is a key cellular energy sensor and regulator of metabolic homeostasis. Although it is best known for its effects on…”
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Systematic Evaluation of the Use of Human Plasma and Serum for Mass-Spectrometry-Based Shotgun Proteomics by Lan, Jiayi, Núñez Galindo, Antonio, Doecke, James, Fowler, Christopher, Martins, Ralph N, Rainey-Smith, Stephanie R, Cominetti, Ornella, Dayon, Loïc

“…Over the last two decades, EDTA-plasma has been used as the preferred sample matrix for human blood proteomic profiling. Serum has also been employed widely…”
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High-throughput and simultaneous quantitative analysis of homocysteine–methionine cycle metabolites and co-factors in blood plasma and cerebrospinal fluid by isotope dilution LC–MS/MS by Guiraud, Seu Ping, Montoliu, Ivan, Da Silva, Laeticia, Dayon, Loïc, Galindo, Antonio Núñez, Corthésy, John, Kussmann, Martin, Martin, Francois-Pierre

“…The methionine cycle is a key pathway contributing to the regulation of human health, with well-established involvement in cardiovascular diseases and…”
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Proteomics reveals unique plasma signatures in constitutional thinness by Cominetti, Ornella, Núñez Galindo, Antonio, Corthésy, John, Carayol, Jérôme, Germain, Natacha, Galusca, Bogdan, Estour, Bruno, Hager, Jörg, Gheldof, Nele, Dayon, Loïc

“…Purpose Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight‐gain…”
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Proteomic Biomarker Discovery in 1000 Human Plasma Samples with Mass Spectrometry by Cominetti, Ornella, Núñez Galindo, Antonio, Corthésy, John, Oller Moreno, Sergio, Irincheeva, Irina, Valsesia, Armand, Astrup, Arne, Saris, Wim H. M, Hager, Jörg, Kussmann, Martin, Dayon, Loïc

“…The overall impact of proteomics on clinical research and its translation has lagged behind expectations. One recognized caveat is the limited size (subject…”
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Obesity shows preserved plasma proteome in large independent clinical cohorts by Cominetti, Ornella, Núñez Galindo, Antonio, Corthésy, John, Valsesia, Armand, Irincheeva, Irina, Kussmann, Martin, Saris, Wim H. M., Astrup, Arne, McPherson, Ruth, Harper, Mary-Ellen, Dent, Robert, Hager, Jörg, Dayon, Loïc

“…Holistic human proteome maps are expected to complement comprehensive profile assessment of health and disease phenotypes. However, methodologies to analyze…”
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A Highly Automated Shotgun Proteomic Workflow: Clinical Scale and Robustness for Biomarker Discovery in Blood by Dayon, Loïc, Núñez Galindo, Antonio, Cominetti, Ornella, Corthésy, John, Kussmann, Martin

“…With recent technological developments, protein biomarker discoveries directly from blood have regained interest due to elevated feasibility. Mass spectrometry…”
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Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation by Valera-Alberni, Miriam, Joffraud, Magali, Miro-Blanch, Joan, Capellades, Jordi, Junza, Alexandra, Dayon, Loïc, Núñez Galindo, Antonio, Sanchez-Garcia, Jose L., Valsesia, Armand, Cercillieux, Angelique, Söllner, Flavia, Ladurner, Andreas G., Yanes, Oscar, Cantó, Carles

“…Mitochondria constantly undergo fusion and fission events, referred as mitochondrial dynamics, which determine mitochondrial architecture and bioenergetics…”
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